Results 41 to 50 of about 4,855,871 (373)

Triiodothyronine suppresses humoral immunity but not T-cell-mediated immune response in incubating female eiders (Somateria mollissima) [PDF]

Gen. Comp. Endocrinol. 151 (2007) 188-194, 2007
Immunity is believed to share limited resources with other physiological functions and this may partly account for the fitness costs of reproduction. Previous studies have shown that the acquired immunity of female common eiders (Somateria mollissima) is suppressed during the incubation fast.
arxiv   +1 more source

To TRIM the Immunity: From Innate to Adaptive Immunity

Frontiers in Immunology, 2020
The tripartite motif (TRIM) proteins have been intensively studied as essential modulators in various biological processes, especially in regulating a wide range of signaling pathways involved in immune responses.
Wenyong Yang, Zhiwen Gu, Huiyuan Zhang, Hongbo Hu   +3 more
semanticscholar   +1 more source

Regulatory T Cells Beyond Autoimmunity: From Pregnancy to Cancer and Cardiovascular Disease

Frontiers in Immunology, 2020
The evolution of the full range of functions of regulatory T cells (Treg) coincides with the evolution of mammalian pregnancy. Accordingly, Treg function has been shown to be crucial for maternal-fetal tolerance and implantation. As reproduction is a key
Elisa Martini, Silvia Giugliano, Silvia Giugliano, Maria Rescigno, Maria Rescigno, Marinos Kallikourdis, Marinos Kallikourdis   +6 more
doaj   +1 more source

Diversity of immune strategies explained by adaptation to pathogen statistics [PDF]

Proc Natl Acad Sci USA 113(31) 8630 (2016), 2015
Biological organisms have evolved a wide range of immune mechanisms to defend themselves against pathogens. Beyond molecular details, these mechanisms differ in how protection is acquired, processed and passed on to subsequent generations -- differences that may be essential to long-term survival.
arxiv   +1 more source

Method for identification of condition-associated public antigen receptor sequences

eLife, 2018
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease ...
Mikhail V Pogorelyy, Anastasia A Minervina, Dmitriy M Chudakov, Ilgar Z Mamedov, Yuri B Lebedev, Thierry Mora, Aleksandra M Walczak   +6 more
doaj   +1 more source

A disease‐associated missense mutation in CYP4F3 affects the metabolism of leukotriene B4 via disruption of electron transfer

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Cytochrome P450 4F3 (CYP4F3) is an ω‐hydroxylase that oxidizes leukotriene B4 (LTB4), prostaglandins, and fatty acid epoxides. LTB4 is synthesized by leukocytes and acts as a chemoattractant for neutrophils, making it an essential component of
Elien Smeets, Shengyun Huang, Xiao Yin Lee, Erika Van Nieuwenhove, Christine Helsen, Florian Handle, Lisa Moris, Sarah El Kharraz, Roy Eerlings, Wout Devlies, Mathijs Willemsen, Leoni Bücken, Teresa Prezzemolo, Stephanie Humblet‐Baron, Arnout Voet, Anne Rochtus, Ann Van Schepdael, Francis deZegher, Frank Claessens   +18 more
doaj   +1 more source

Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection [PDF]

, 2018
Throughout the lifespan of an individual, the immune system undergoes complex changes while facing novel and chronic infections. Helminths, which infect over one billion people and impose heavy livestock productivity losses, typically cause chronic ...
Babayan, Simon A., Duprez, Jessica S., Selman, Colin, Sinclair, Amy   +3 more
core   +1 more source

Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1

eLife, 2023
Inhibitory CD4+ T cells have been linked with suboptimal immune responses against cancer and pathogen chronicity. However, the mechanisms that underpin the development of these regulatory cells, especially in the context of ongoing antigen exposure, have
Mathew Clement, Kristin Ladell, Kelly L Miners, Morgan Marsden, Lucy Chapman, Anna Cardus Figueras, Jake Scott, Robert Andrews, Simon Clare, Valeriia V Kriukova, Ksenia R Lupyr, Olga V Britanova, David R Withers, Simon A Jones, Dmitriy M Chudakov, David A Price, Ian R Humphreys   +16 more
doaj   +1 more source

Advances in innate immune memory of macrophages

Exploration of Immunology, 2022
Immunity is usually classified into two categories: innate immunity and adaptive immunity, distinguished by the process and characteristics of the immunological impact. It was widely assumed that only adaptive immunity possessed memory features; however,
Safir Ullah Khan, Munir Ullah Khan
doaj   +1 more source

Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoires [PDF]

Mol. Syst. Des. Eng. (2019), 2019
The adaptive immune system is a natural diagnostic and therapeutic. It recognizes threats earlier than clinical symptoms manifest and neutralizes antigen with exquisite specificity. Recognition specificity and broad reactivity is enabled via adaptive B- and T-cell receptors: the immune receptor repertoire.
arxiv   +1 more source