Results 81 to 90 of about 5,085,110 (360)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Current Status of Defensins and Their Role in Innate and Adaptive Immunity [PDF]

, 2002
Naturally occurring antimicrobial cationic polypeptides play a major role in innate and adaptive immunity. These polypeptides are found to be either linear and unstructured or structured through disulfide bonds.
Dentino, Andrew R., Raj, Periathamby A.
core   +1 more source

The regulatory roles of neutrophils in adaptive immunity

Cell Communication and Signaling, 2019
Neutrophils have long been considered as cells playing a crucial role in the immune defence against invading pathogens. Accumulating evidence strongly supported the direct and indirect regulatory effects of neutrophils on adaptive immunity.
Yang Li, Wei Wang, Fan Yang, Yanan Xu, Chang Feng, Yong Zhao   +5 more
semanticscholar   +1 more source

Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism

eLife
Suppressive function of regulatory T cells (Treg) is dependent on signaling of their antigen receptors triggered by cognate self, dietary, or microbial peptides presented on MHC II.
Tatyana O Nakonechnaya, Bruno Moltedo, Ekaterina V Putintseva, Sofya Leyn, Dmitry A Bolotin, Olga V Britanova, Mikhail Shugay, Dmitriy M Chudakov   +7 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The evolution of resistance through costly acquired immunity [PDF]

, 2004
We examine the evolutionary dynamics of resistance to parasites through acquired immunity. Resistance can be achieved through the innate mechanisms of avoidance of infection and reduced pathogenicity once infected, through recovery from infection and ...
Boots M., Michael Boots, Roger G. Bowers
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Adaptive Immunity [PDF]

Stroke, 2007
The 3 talks in this session all deal with aspects of immune response regulation and dysregulation that can be either protective or harmful in brain ischemia. As an introduction to this session, I will review several models of immune response regulation and relate these models to the upcoming talks.1 Under normal circumstances, antigen presenting cells (
openaire   +1 more source

Inactivated vaccine fueled adaptive immune responses to Omicron in 2‐year COVID‐19 convalescents [PDF]

, 2023
Maoshun Liu, Jie Zhang, Lei Li, Jinmin Tian, Mengjie Yang, Bingli Shang, Xin Wang, Min Li, Hongmei Li, Can Yue, Sijia Yao, Ying Lin, Yuanyuan Guo, Kexin Zong, Danni Zhang, Yingze Zhao, Kun Cai, Shaobo Dong, Shengping Xu, Jianbo Zhan, George F. Gao, William J. Liu   +21 more
openalex   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source