Results 241 to 250 of about 5,867,069 (283)

Human NKG2C+ adaptive NK cells for Cancer immunotherapy.

International Immunopharmacology
Natural killer (NK) cells are key components of the innate immune system and play a pivotal role in tumor immunosurveillance. In recent years, a subset of NKG2C+ adaptive NK cells induced by human cytomegalovirus (HCMV) infection has attracted ...
Qiao Tang, Zhi-Gang Tian, Jia-Cheng Bi
semanticscholar   +2 more sources

From the “missing self” hypothesis to adaptive NK cells: Insights of NK cell‐mediated effector functions in immune surveillance

Journal of Leukocyte Biology, 2019
The original discovery of NK cells approximately 40 yr ago was based on their unique capability to kill tumor cells without prior sensitization or priming, a process named natural cytotoxicity.
Mario Ernesto Cruz-Muñoz, Lucero Valenzuela‐Vázquez, J. Sánchez‐Herrera, Jesús Santa-Olalla Tapia   +3 more
semanticscholar   +3 more sources

Method to Study Adaptive NK Cells Following MCMV Infections.

Methods in molecular biology, 2022
Immunological memory is a fundamental feature of the adaptive immune system that protects the host from recurrent infections from pathogens. Natural killer (NK) cells are a predominant member of the innate immune system that lack clonotypic receptors, which are essential for memory formation.
Mohamed Khalil, Ao Mei, Elaheh Hashemi, Dandan Wang, M. Schumacher, S. Terhune, Subramaniam Malarkannan   +6 more
semanticscholar   +3 more sources

ADAPted secretion of cytokines in NK cells

Nature Immunology, 2013
A signaling module consisting of the adaptor ADAP and the Carma1–Bcl-10–MALT1 (CBM)–TAK1 signalosome has been shown to selectively induce cytokine secretion but not cytotoxicity in natural killer cells.
Vivier, Eric, Ugolini, Sophie, Nunès, Jacques   +2 more
openaire   +1 more source

Epigenetic Regulation of Adaptive NK Cell Diversification

Trends in Immunology, 2016
Natural killer (NK) cells were previously considered to represent short-lived, innate lymphocytes. However, mouse models have revealed expansion and persistence of differentiated NK cell subsets in response to cytomegalovirus (CMV) infection, paralleling antigen-specific T cell differentiation.
Bianca Tesi, Heinrich Schlums, Frank Cichocki, Yenan T. Bryceson   +3 more
openaire   +2 more sources

The NK cell receptor repertoire: formation, adaptation and exploitation

Current Opinion in Immunology, 2003
The identification of NK cell receptors specific for MHC class I molecules has greatly improved our knowledge of NK cell reactivity and specificity. Inhibitory receptors prevent NK cell activation directed against cells expressing self-MHC class I molecules.
Held W, Coudert JD, Zimmer J
openaire   +3 more sources

Bridging Innate NK Cell Functions with Adaptive Immunity

2011
Killer Ig-like receptors (KIRs) are major human NK receptors displaying either inhibitory or activating functions which recognize allotypic determinants of HLA-class I molecules. Surprisingly, NK cell treatment with CpG-ODN (TLR9 ligands) results in selective down-modulation of KIR3DL2, its co-internalization with CpG-ODN and its translocation to TLR9 ...
MARCENARO, EMANUELA, CARLOMAGNO, SIMONA, PESCE, SILVIA, MORETTA, ALESSANDRO, SIVORI, SIMONA   +4 more
openaire   +4 more sources

NK cell adaptation in the tumor microenvironment: Insights for NK cell-based immunotherapy

Cytokine & Growth Factor Reviews
Natural killer (NK) cells serve as critical first responders within the immune system, orchestrating antitumor responses by directly eliminating malignant cells and modulating broader immune functions. Their capacity to recognize stressed targets without MHC-restricted neoantigen presentation, together with a favorable safety profile, underpins growing
Yaopeng, Li, Yan, Gao, Liangliang, Wang, Jingwen, Si   +3 more
openaire   +2 more sources

NK cells interactions with dendritic cells shape innate and adaptive immunity

Frontiers in Bioscience, 2008
While natural killer (NK) cells received their name from their ability to mediate spontaneous cytotoxicity, it has recently become clear that they require activation to target most transformed and infected cells. Dendritic cells (DCs) have been shown to mediate NK cell activation during innate immune responses.
Fabienne, Brilot, Till, Strowig, Christian, Munz   +2 more
openaire   +2 more sources

Proliferation and Differentiation of Alloselective NK Cells after Alloimmunization—Evidence for an Adaptive NK Response

Cellular Immunology, 1999
We have previously demonstrated the activation of NK cells exhibiting RT1 allele-specific cytolytic activity following intraperitoneal immunization of certain rat strains with allogeneic cells. In the present study, we show that the NK allocytolytic activity in BN (RT1(n)) rats immunized with WF (RT1(u)) cells was associated with an increased ...
E, Petersson, G, Hedlund
openaire   +2 more sources