Results 261 to 270 of about 103,353 (290)
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NK cells interactions with dendritic cells shape innate and adaptive immunity
Frontiers in Bioscience, 2008While natural killer (NK) cells received their name from their ability to mediate spontaneous cytotoxicity, it has recently become clear that they require activation to target most transformed and infected cells. Dendritic cells (DCs) have been shown to mediate NK cell activation during innate immune responses.
Fabienne, Brilot +2 more
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Cellular Immunology, 1999
We have previously demonstrated the activation of NK cells exhibiting RT1 allele-specific cytolytic activity following intraperitoneal immunization of certain rat strains with allogeneic cells. In the present study, we show that the NK allocytolytic activity in BN (RT1(n)) rats immunized with WF (RT1(u)) cells was associated with an increased ...
E, Petersson, G, Hedlund
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We have previously demonstrated the activation of NK cells exhibiting RT1 allele-specific cytolytic activity following intraperitoneal immunization of certain rat strains with allogeneic cells. In the present study, we show that the NK allocytolytic activity in BN (RT1(n)) rats immunized with WF (RT1(u)) cells was associated with an increased ...
E, Petersson, G, Hedlund
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Immune Adaptation to Environmental Influence: The Case of NK Cells and HCMV
Trends in Immunology, 2016The immune system of an individual human is determined by heritable traits and a continuous process of adaptation to a broad variety of extrinsic, non-heritable factors such as viruses, bacteria, dietary components and more. Cytomegalovirus (CMV) successfully infects the majority of the human population and establishes latency, thereby exerting a life ...
Rölle A, Brodin P
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Selection, tuning, and adaptation in mouse
SummaryNatural killer (NK) cells recognize transformed cells with an array of germline‐encoded inhibitory and activating receptors. Inhibitory Ly49 receptors bind major histocompatibility complex class I (MHC‐I) molecules, providing a mechanism by which NK cells maintain self‐tolerance yet eliminate cells expressing reduced levels of MHC‐I ...
Nadir, Kadri +2 more
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Peripheral NK cell phenotypes: multiple changing of faces of an adapting, developing cell
Molecular Immunology, 2005We have defined the existence of developmental relationships among human peripheral NK cells with distinct phenotypic and functional characteristics. These findings closely parallel the changes that occur in vivo during NK cell development, and in vitro in experimental culture systems supporting NK cell generation from hematopoietic progenitors.
Bice, Perussia +2 more
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Journal of Leukocyte Biology, 2019
Abstract The original discovery of NK cells approximately 40 yr ago was based on their unique capability to kill tumor cells without prior sensitization or priming, a process named natural cytotoxicity. Since then, several studies have documented that NK cells can kill hematopoietic and nonhematopoietic cancer cells.
Mario Ernesto, Cruz-Muñoz +3 more
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Abstract The original discovery of NK cells approximately 40 yr ago was based on their unique capability to kill tumor cells without prior sensitization or priming, a process named natural cytotoxicity. Since then, several studies have documented that NK cells can kill hematopoietic and nonhematopoietic cancer cells.
Mario Ernesto, Cruz-Muñoz +3 more
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2B4 co-stimulation: NK cells and their control of adaptive immune responses
Molecular Immunology, 2005NK cells have primarily been defined by their ability to kill infected cells, tumor cells and some normal cells expressing low levels of MHC class I molecules. NK cells have also been shown to affect adaptive immune responses by their production of both pro- and anti-inflammatory cytokines.
Erika, Assarsson +4 more
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NK cell regulation by SLAM family receptors and SAP‐related adapters
Immunological Reviews, 2006Summary: Signaling lymphocytic activating molecule (SLAM) family receptors and SLAM‐associated protein (SAP)‐related adapters play several important roles in the immune system. Natural killer (NK) cells express at least three members of the SLAM family.
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