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Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Human adaptive-like "memory" CD56(dim)CD16(+) natural killer (NK) cells in peripheral blood from cytomegalovirus-seropositive individuals have been extensively investigated in recent years and are currently explored as a treatment strategy for ...
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ADAPted secretion of cytokines in NK cells
Nature Immunology, 2013A signaling module consisting of the adaptor ADAP and the Carma1–Bcl-10–MALT1 (CBM)–TAK1 signalosome has been shown to selectively induce cytokine secretion but not cytotoxicity in natural killer cells.
Vivier, Eric +2 more
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Epigenetic Regulation of Adaptive NK Cell Diversification
Trends in Immunology, 2016Natural killer (NK) cells were previously considered to represent short-lived, innate lymphocytes. However, mouse models have revealed expansion and persistence of differentiated NK cell subsets in response to cytomegalovirus (CMV) infection, paralleling antigen-specific T cell differentiation.
Bianca Tesi +3 more
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The NK cell receptor repertoire: formation, adaptation and exploitation
Current Opinion in Immunology, 2003The identification of NK cell receptors specific for MHC class I molecules has greatly improved our knowledge of NK cell reactivity and specificity. Inhibitory receptors prevent NK cell activation directed against cells expressing self-MHC class I molecules.
Held W, Coudert JD, Zimmer J
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Method to Study Adaptive NK Cells Following MCMV Infections
2022Immunological memory is a fundamental feature of the adaptive immune system that protects the host from recurrent infections from pathogens. Natural killer (NK) cells are a predominant member of the innate immune system that lack clonotypic receptors, which are essential for memory formation.
Mohamed, Khalil +6 more
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Bridging Innate NK Cell Functions with Adaptive Immunity
2011Killer Ig-like receptors (KIRs) are major human NK receptors displaying either inhibitory or activating functions which recognize allotypic determinants of HLA-class I molecules. Surprisingly, NK cell treatment with CpG-ODN (TLR9 ligands) results in selective down-modulation of KIR3DL2, its co-internalization with CpG-ODN and its translocation to TLR9 ...
MARCENARO, EMANUELA +4 more
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Tissue-specific determinants of the adaptive NK cell response
The Journal of Immunology, 2023Abstract Natural killer (NK) cells are circulating innate lymphocytes that are poised to respond rapidly upon encounter with cancer or virally-infected cells as well as proinflammatory cytokines. In addition to their early role in immune responses, it is now appreciated that NK cells can also take on features of adaptive lymphocytes such
Adriana M Mujal +6 more
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NK cell adaptation in the tumor microenvironment: Insights for NK cell-based immunotherapy
Cytokine & Growth Factor ReviewsNatural killer (NK) cells serve as critical first responders within the immune system, orchestrating antitumor responses by directly eliminating malignant cells and modulating broader immune functions. Their capacity to recognize stressed targets without MHC-restricted neoantigen presentation, together with a favorable safety profile, underpins growing
Yaopeng, Li +3 more
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