Results 251 to 260 of about 5,867,069 (283)
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NK cells in autoimmune diseases: Linking innate and adaptive immune responses.
Autoimmunity Reviews, 2018The pathogenesis of autoimmunity remains to be fully elucidated, although the contribution of genetic and environmental factors is generally recognized. Despite autoimmune conditions are principally due to T and B lymphocytes, NK cells also appear to play a role in the promotion and/or maintenance of altered adaptive immune responses or in peripheral ...
Elena Gianchecchi +2 more
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Immune Adaptation to Environmental Influence: The Case of NK Cells and HCMV
Trends in Immunology, 2016The immune system of an individual human is determined by heritable traits and a continuous process of adaptation to a broad variety of extrinsic, non-heritable factors such as viruses, bacteria, dietary components and more. Cytomegalovirus (CMV) successfully infects the majority of the human population and establishes latency, thereby exerting a life ...
Rölle A, Brodin P
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Selection, tuning, and adaptation in mouse
SummaryNatural killer (NK) cells recognize transformed cells with an array of germline‐encoded inhibitory and activating receptors. Inhibitory Ly49 receptors bind major histocompatibility complex class I (MHC‐I) molecules, providing a mechanism by which NK cells maintain self‐tolerance yet eliminate cells expressing reduced levels of MHC‐I ...
Nadir, Kadri +2 more
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Peripheral NK cell phenotypes: multiple changing of faces of an adapting, developing cell
Molecular Immunology, 2005We have defined the existence of developmental relationships among human peripheral NK cells with distinct phenotypic and functional characteristics. These findings closely parallel the changes that occur in vivo during NK cell development, and in vitro in experimental culture systems supporting NK cell generation from hematopoietic progenitors.
Bice, Perussia +2 more
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2B4 co-stimulation: NK cells and their control of adaptive immune responses
Molecular Immunology, 2005NK cells have primarily been defined by their ability to kill infected cells, tumor cells and some normal cells expressing low levels of MHC class I molecules. NK cells have also been shown to affect adaptive immune responses by their production of both pro- and anti-inflammatory cytokines.
Erika, Assarsson +4 more
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NK cell regulation by SLAM family receptors and SAP‐related adapters
Immunological Reviews, 2006Summary: Signaling lymphocytic activating molecule (SLAM) family receptors and SLAM‐associated protein (SAP)‐related adapters play several important roles in the immune system. Natural killer (NK) cells express at least three members of the SLAM family.
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Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells
Cancer immunology research, 2017Lisa L. Liu +10 more
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Natural Killer Cells: From Innate to Adaptive Features
Annual Review of Immunology, 2021Joseph C Sun +2 more
exaly
ABSTRACT Natural killer (NK) cell neoplasms are a diverse group of entities with often nonspecific clinical presentations, making immunophenotyping essential for diagnosis. Immunophenotyping by flow cytometry can identify clonal NK cell populations by detecting restricted expression patterns of NK cell receptors such ...
Aaron J. Wilk, Gary Gitana, Jean Oak
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Aaron J. Wilk, Gary Gitana, Jean Oak
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