Results 111 to 120 of about 3,973,865 (282)

The partial adaptation strategy for online-adaptive proton therapy: A proof of concept study in head and neck cancer patients.

Medical Physics (Lancaster)
BACKGROUND The accuracy of intensity-modulated proton therapy (IMPT) is greatly affected by anatomy variations that might occur during the treatment course. Online plan adaptations have been proposed as a solution to intervene promptly during a treatment
Virginia Gambetta, Albin Fredriksson, Stefan Menkel, C. Richter, K. Stützer   +4 more
semanticscholar   +1 more source

Intensity-Modulated Proton Therapy Adaptive Planning for Patients with Oropharyngeal Cancer

International Journal of Particle Therapy, 2017
The authors aimed to illustrate the potential dose differences to clinical target volumes (CTVs) and organs-at-risk (OARs) volumes after proton adaptive treatment planning was used.The records of 10 patients with oropharyngeal cancer were retrospectively reviewed.
Richard Y, Wu, Amy Y, Liu, Terence T, Sio, Pierre, Blanchard, Cody, Wages, Mayankkumar V, Amin, Gary B, Gunn, Uwe, Titt, Rong, Ye, Kazumichi, Suzuki, Michael T, Gillin, Xiaorong R, Zhu, Radhe, Mohan, Steven J, Frank   +13 more
openaire   +2 more sources

Nanoporous Silica Embedded in Nanoporous Platinum: A Versatile Composite Coating for Implant‐Associated Drug Delivery From Neuronal Electrodes

Advanced Materials Technologies, EarlyView.
Nanoporous silica nanoparticles incorporated in nanoporous platinum offer the possibility for implant‐associated drug delivery from neuronal electrodes. ABSTRACT Sensorineural hearing loss, resulting from damage to the hair cells of the inner ear, profoundly impairs quality of life.
Mosaieb Habib, Tim‐Joshua Strauß, Jennifer Harre, Madeleine Goblet, Florian Klodwig‐Kirstein, Jana Schwieger, Michaela Kreienmeyer, Verena Scheper, Athanasia Warnecke, Nina Ehlert, Peter Behrens   +10 more
wiley   +1 more source

Daily adaptive proton therapy: challenges and clinical potential

, 2020
With proton therapy, highly conformal dose can be applied to the tumor while sparing the surrounding organs at risk. Protons are however sensitive to density changes in the beam path: If the patient anatomy is changing, the resulting dose is distorted. To restore the initial plan quality, the plan has to be adapted. In this thesis, the concept of daily
openaire   +2 more sources

Hydro‐ and Lipophilicity of Molecular‐Size‐Controlled Hydrogel Drug Carriers

Advanced Materials Technologies, EarlyView.
We investigate nano‐sized hydrogel drug carriers with tailored hydro‐ and lipophilicity. We design their encapsulation and structure‐forming capabilities and follow them in real time during fabrication using time‐resolved and in situ grazing incidence x‐ray scattering.
Elisabeth Erbes, Naireeta Biswas, Calvin J. Gavillet, Matthias Schwartzkopf, Krishnayan Basuroy, Qing Chen, Andrei Chumakov, Susann Frenzke, Marc Gensch, Korneliya Gordeyeva, Patrycja Kielb, Sonja Kirchner, Volker Körstgens, Peter Müller‐Buschbaum, Henrike M. Müller‐Werkmeister, Jan Rubeck, Sreevidya Thekku Veedu, Jose de Jesus Velazquez‐Garcia, Vivian Waclawek, Daniel Söderberg, Stephan V. Roth, Simone Techert   +21 more
wiley   +1 more source

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Magnetic resonance spectroscopy in the evaluation of treatment efficacy in unipolar major depressive disorder: a review of the literature [PDF]

, 2012
More and more neuroimaging studies are using in vivo proton magnetic resonance spectroscopy (1H-MRS) to explore correlates of response to therapy in major depressive disorder (MDD). Their aim is to further understanding of the effects of neurotransmitter
A. Pichiecchio, F. Barale, M. Pasin, Biondi, Massimo, Palesi, Fulvia, Caverzasi, Edoardo, Pasquini, Massimo, G. Castellazzi, Bastianello, Stefano, A. Calligaro, Barale, Francesco, E. Caverzasi, Pichiecchio, Anna, Pasin, Marino, Castellazzi, Gloria, Calligaro, Alessandro, F. Palesi, Poloni, Guy, G. U. Poloni   +18 more
core   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

A treatment-site-specific evaluation of commercial synthetic computed tomography solutions for proton therapy

Physics and Imaging in Radiation Oncology
Background and purpose: Despite the superior dose conformity of proton therapy, the dose distribution is sensitive to daily anatomical changes, which can affect treatment accuracy.
Ping Lin Yeap, Yun Ming Wong, Kang Hao Lee, Calvin Wei Yang Koh, Kah Seng Lew, Clifford Ghee Ann Chua, Andrew Wibawa, Zubin Master, James Cheow Lei Lee, Sung Yong Park, Hong Qi Tan   +10 more
doaj   +1 more source

A comparative study on automatic treatment planning for online adaptive proton therapy of esophageal cancer: which combination of deformable registration and deep learning planning tools performs the best?

Physics in Medicine and Biology
Objective. To demonstrate the feasibility of integrating fully-automated online adaptive proton therapy strategies (OAPT) within a commercially available treatment planning system and underscore what limits their clinical implementation. These strategies
C. Draguet, P. Populaire, Macarena Chocan Vera, Albin Fredriksson, K. Haustermans, J. Lee, A. B. Barragan Montero, E. Sterpin   +7 more
semanticscholar   +1 more source