Results 31 to 40 of about 42,601 (251)
Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons
Cell Reports, 2020 Summary: Adenosine-to-inosine RNA editing, catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes, alters RNA sequences from those encoded by DNA. These editing events are dynamically regulated, but few trans regulators of ADARs are known in vivo.
Anne L. Sapiro +8 more
doaj +1 more source
Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish. [PDF]
PLoS Genetics, 2015 Fragile X syndrome (FXS) is the most frequent inherited form of mental retardation. The cause for this X-linked disorder is the silencing of the fragile X mental retardation 1 (fmr1) gene and the absence of the fragile X mental retardation protein (Fmrp).
Adi Shamay-Ramot +10 more
doaj +1 more source
Global Medical Genetics, 2023 Interferon (IFN)-β is the first-line disease management choice in multiple sclerosis (MS) with profound effects; however, in up to 50% of patients, clinical response does not occur.
Fakhr Fakhr +6 more
doaj +1 more source
ADARs have effects beyond RNA editing [PDF]
Cell Cycle, 2009 hairpin-mediated silencing and partially restores the red eye pigment. Inactive ADAR1p150 restored the pigmentation to 40% of ADAR1p150 levels suggesting that binding alone can influence processing of long duplexes into siRNAs. Cleavage by DICER is thought to be affected as this antagonism occurs in the cytoplasm and DICER can partially suppress the ...
Heale, Bret S E +2 more
openaire +3 more sources
DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. [PDF]
, 2017 Adenosine deaminases that act on RNA (ADARs) carry out adenosine (A) to inosine (I) editing reactions with a known requirement for duplex RNA. Here, we show that ADARs also react with DNA/RNA hybrid duplexes.
Beal, Peter A +2 more
core +1 more source
Measuring Tie Strength in Implicit Social Networks [PDF]
, 2011 Given a set of people and a set of events they attend, we address the problem of measuring connectedness or tie strength between each pair of persons given that attendance at mutual events gives an implicit social network between people.
Eliassi-Rad, Tina, Gupte, Mangesh
core +2 more sources
Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome
Cell Reports, 2015 Little is known about how RNA editing operates in cancer. Transcriptome analysis of 68 normal and cancerous breast tissues revealed that the editing enzyme ADAR acts uniformly, on the same loci, across tissues.
Debora Fumagalli +18 more
doaj +1 more source
Promoting RNA editing by ADAR attraction [PDF]
Genome Biology, 2017 Concentration is important and not only while driving; a new study indicates how an adjacent genomic element helps to increase the efficiency of a specific adenosine to inosine RNA editing reaction, by providing a means to increase the local concentration of the RNA editing enzyme ADAR.
Miri Danan-Gotthold, Erez Y. Levanon
openaire +3 more sources
Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. [PDF]
, 2016 Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Beal, Peter A, Wang, Yuru
core +1 more source
ADAR Editing Wobbles the MicroRNA World [PDF]
ACS Chemical Biology, 2007 Recent work reveals that adenosine-to-inosine editing occurs in a number of cellular microRNAs (miRNAs). Such editing is shown to diminish the expression of one miRNA and alter the target specificity of another. This changes our current views significantly by not only increasing the repertoire of miRNAs and their potential targets, but also providing ...
Asis K, Das, Gordon G, Carmichael
openaire +2 more sources