Results 31 to 40 of about 8,355 (219)
Promoting RNA editing by ADAR attraction [PDF]
Genome Biology, 2017 Concentration is important and not only while driving; a new study indicates how an adjacent genomic element helps to increase the efficiency of a specific adenosine to inosine RNA editing reaction, by providing a means to increase the local concentration of the RNA editing enzyme ADAR.
Miri Danan-Gotthold, Erez Y. Levanon
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8-Azaadenosine and 8-Chloroadenosine are not Selective Inhibitors of ADAR [PDF]
Cancer Research Communications, 2021 The RNA editing enzyme ADAR is an attractive therapeutic target for multiple cancers. Through its deaminase activity, ADAR edits adenosine to inosine in double-stranded RNAs. Loss of ADAR in some cancer cell lines causes activation of the type I IFN pathway and the PKR translational repressor, leading to inhibition of proliferation and stimulation of ...
Kyle A. Cottrell +3 more
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BMC Biology, 2020 Background In fly brains, the Drosophila Adar (adenosine deaminase acting on RNA) enzyme edits hundreds of transcripts to generate edited isoforms of encoded proteins.
Anzer Khan +8 more
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Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish. [PDF]
PLoS Genetics, 2015 Fragile X syndrome (FXS) is the most frequent inherited form of mental retardation. The cause for this X-linked disorder is the silencing of the fragile X mental retardation 1 (fmr1) gene and the absence of the fragile X mental retardation protein (Fmrp).
Adi Shamay-Ramot +10 more
doaj +1 more source
Global Medical Genetics, 2023 Interferon (IFN)-β is the first-line disease management choice in multiple sclerosis (MS) with profound effects; however, in up to 50% of patients, clinical response does not occur.
Fakhr Fakhr +6 more
doaj +1 more source
Onset of Quantum Chaos in Random Field Theories [PDF]
, 2022 We study the quantum Lyapunov exponent $\lambda_L$ in theories with spacetime-independent disorder. We first derive self-consistency equations for the two- and four-point functions for products of $N$ models coupled by disorder at large $N$, generalizing the equations appearing in SYK-like models.
arxiv +1 more source
Adar is essential for optimal presynaptic function [PDF]
Molecular and Cellular Neuroscience, 2013 RNA editing is a powerful way to recode genetic information. Because it potentially affects RNA targets that are predominantly present in neurons, it is widely hypothesized to affect neuronal structure and physiology. Across phyla, loss of the enzyme responsible for RNA editing, Adar, leads to behavioral changes, impaired locomotion, neurodegeneration ...
Maryvi Gonzalez +4 more
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Nucleoside Analogs in ADAR Guide Strands Enable Editing at 5'-GA Sites. [PDF]
BiomoleculesManjunath A +9 more
europepmc +2 more sources
ADAR Editing in Viruses: An Evolutionary Force to Reckon with [PDF]
Genome Biology and Evolution, 2021 AbstractAdenosine Deaminases that Act on RNA (ADARs) are RNA editing enzymes that play a dynamic and nuanced role in regulating transcriptome and proteome diversity. This editing can be highly selective, affecting a specific site within a transcript, or nonselective, resulting in hyperediting.
Helen Piontkivska +3 more
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ADAR RNA editing below the backbone [PDF]
RNA, 2017 ADAR RNA editing enzymes (adenosine deaminases acting on RNA) that convert adenosine bases to inosines were first identified biochemically 30 years ago. Since then, studies on ADARs in genetic model organisms, and evolutionary comparisons between them, continue to reveal a surprising range of pleiotropic biological effects of ADARs. This review focuses
Liam Keegan +3 more
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