Results 31 to 40 of about 40,794 (233)

8-Azaadenosine and 8-Chloroadenosine are not Selective Inhibitors of ADAR [PDF]

Cancer Research Communications, 2021
The RNA editing enzyme ADAR is an attractive therapeutic target for multiple cancers. Through its deaminase activity, ADAR edits adenosine to inosine in double-stranded RNAs. Loss of ADAR in some cancer cell lines causes activation of the type I IFN pathway and the PKR translational repressor, leading to inhibition of proliferation and stimulation of ...
Kyle A. Cottrell, Luisangely Soto-Torres, Michael G. Dizon, Jason D. Weber   +3 more
openaire   +4 more sources

Adar is essential for optimal presynaptic function [PDF]

Molecular and Cellular Neuroscience, 2013
RNA editing is a powerful way to recode genetic information. Because it potentially affects RNA targets that are predominantly present in neurons, it is widely hypothesized to affect neuronal structure and physiology. Across phyla, loss of the enzyme responsible for RNA editing, Adar, leads to behavioral changes, impaired locomotion, neurodegeneration ...
Maryvi Gonzalez, Maria Bykhovskaia, Bruno Marie, Carolina Maldonado, Daniel Alicea   +4 more
openaire   +3 more sources

ADAR RNA editing below the backbone [PDF]

RNA, 2017
ADAR RNA editing enzymes (adenosine deaminases acting on RNA) that convert adenosine bases to inosines were first identified biochemically 30 years ago. Since then, studies on ADARs in genetic model organisms, and evolutionary comparisons between them, continue to reveal a surprising range of pleiotropic biological effects of ADARs. This review focuses
Liam Keegan, Anzer Khan, Dragana Vukic, Mary O'Connell   +3 more
openaire   +2 more sources

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome

Cell Reports, 2015
Little is known about how RNA editing operates in cancer. Transcriptome analysis of 68 normal and cancerous breast tissues revealed that the editing enzyme ADAR acts uniformly, on the same loci, across tissues.
Debora Fumagalli, David Gacquer, Françoise Rothé, Anne Lefort, Frederick Libert, David Brown, Naima Kheddoumi, Adam Shlien, Tomasz Konopka, Roberto Salgado, Denis Larsimont, Kornelia Polyak, Karen Willard-Gallo, Christine Desmedt, Martine Piccart, Marc Abramowicz, Peter J. Campbell, Christos Sotiriou, Vincent Detours   +18 more
doaj   +1 more source

Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons

Cell Reports, 2020
Summary: Adenosine-to-inosine RNA editing, catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes, alters RNA sequences from those encoded by DNA. These editing events are dynamically regulated, but few trans regulators of ADARs are known in vivo.
Anne L. Sapiro, Emily C. Freund, Lucas Restrepo, Huan-Huan Qiao, Amruta Bhate, Qin Li, Jian-Quan Ni, Timothy J. Mosca, Jin Billy Li   +8 more
doaj   +1 more source

Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish. [PDF]

PLoS Genetics, 2015
Fragile X syndrome (FXS) is the most frequent inherited form of mental retardation. The cause for this X-linked disorder is the silencing of the fragile X mental retardation 1 (fmr1) gene and the absence of the fragile X mental retardation protein (Fmrp).
Adi Shamay-Ramot, Khen Khermesh, Hagit T Porath, Michal Barak, Yishay Pinto, Chaim Wachtel, Alona Zilberberg, Tali Lerer-Goldshtein, Sol Efroni, Erez Y Levanon, Lior Appelbaum   +10 more
doaj   +1 more source

ADAR Expression and Single Nucleotide Variants in Multiple Sclerosis Patients Affect the Response to Interferon Beta Therapy

Global Medical Genetics, 2023
Interferon (IFN)-β is the first-line disease management choice in multiple sclerosis (MS) with profound effects; however, in up to 50% of patients, clinical response does not occur.
Fakhr Fakhr, Shaygannejad Shaygannejad, Khorrami Khorrami, Saberi Saberi, Mirmosayyeb Mirmosayyeb, Sadeghi Sadeghi, Kheirollahi Kheirollahi   +6 more
doaj   +1 more source

DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. [PDF]

, 2017
Adenosine deaminases that act on RNA (ADARs) carry out adenosine (A) to inosine (I) editing reactions with a known requirement for duplex RNA. Here, we show that ADARs also react with DNA/RNA hybrid duplexes.
Beal, Peter A, Lorenzo, Claire, Zheng, Yuxuan   +2 more
core   +1 more source

Prediction of scientific collaborations through multiplex interaction networks [PDF]

, 2020
Link prediction algorithms can help to understand the structure and dynamics of scientific collaborations and the evolution of Science. However, available algorithms based on similarity between nodes of collaboration networks are bounded by the limited ...
Aleta, Alberto, Moreno, Yamir, Paolotti, Daniela, Starnini, Michele, Tuninetti, Marta   +4 more
core   +4 more sources

ADAR Editing in Viruses: An Evolutionary Force to Reckon with [PDF]

Genome Biology and Evolution, 2021
AbstractAdenosine Deaminases that Act on RNA (ADARs) are RNA editing enzymes that play a dynamic and nuanced role in regulating transcriptome and proteome diversity. This editing can be highly selective, affecting a specific site within a transcript, or nonselective, resulting in hyperediting.
Helen Piontkivska, Benjamin Wales-McGrath, Michael Miyamoto, Marta L Wayne   +3 more
openaire   +2 more sources