Results 41 to 50 of about 42,221 (215)
Global Transcriptome Analysis of RNA Abundance Regulation by ADAR in Lung Adenocarcinoma
EBioMedicine, 2018 Despite tremendous advances in targeted therapies against lung adenocarcinoma, the majority of patients do not benefit from personalized treatments. A deeper understanding of potential therapeutic targets is crucial to increase the survival of patients ...
Michael F. Sharpnack +7 more
doaj +1 more source
Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system [PDF]
, 2013 The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal signaling during development and in maintaining the stability of established networks in the face of altered sensory input.
Ales eBalik +3 more
core +2 more sources
Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections
BMC Genomics, 2023 Background RNA editing is a process that increases transcriptome diversity, often through Adenosine Deaminases Acting on RNA (ADARs) that catalyze the deamination of adenosine to inosine.
Benjamin Wales-McGrath +2 more
doaj +1 more source
, 1937 Creagán na hOla Graveyard in the Parish of Adare / Murphy, Kitty -- How Creagán na hOla Got Its Name / Murphy, Kitty -- Creagán na hOla / Hickey, Mary -- Desmonds' Castle, Adare / Hickey, Mary -- St Brigid's Well / Fennell, Brigid -- My School District - Shountrade / Fennell, Brigid -- Seanbheann, Rour, Adare / Monckton, Mary -- Old Relic of the Fenian
Shountrade, Adare +16 more
openaire +1 more source
ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression
Cell Reports, 2013 Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine, which is then recognized as guanosine. To study the role of ADAR proteins in RNA editing and gene regulation, we sequenced and compared the DNA and RNA of human B cells.
Isabel X. Wang +5 more
doaj +1 more source
, 1937 A collection of folklore and local history stories from Adare Convent (school) (Adare, Co. Limerick), collected as part of the Schools' Folklore Scheme, 1937-1938 under the supervision of teacher An tSr. Mechtildes.
Adare Convent +23 more
openaire +1 more source
Inferring Person-to-person Proximity Using WiFi Signals [PDF]
, 2016 Today's societies are enveloped in an ever-growing telecommunication infrastructure. This infrastructure offers important opportunities for sensing and recording a multitude of human behaviors.
Lehmann, Sune +4 more
core +2 more sources
Unveiling RNA Editing by ADAR and APOBEC Protein Gene Families
Frontiers in Bioscience-LandmarkRNA editing is a crucial post-transcriptional modification that alters the transcriptome and proteome and affects many cellular processes, including splicing, microRNA specificity, stability of RNA molecules, and protein structure.
Alexander Modestov +2 more
doaj +1 more source
Adar is essential for optimal presynaptic function [PDF]
Molecular and Cellular Neuroscience, 2013 RNA editing is a powerful way to recode genetic information. Because it potentially affects RNA targets that are predominantly present in neurons, it is widely hypothesized to affect neuronal structure and physiology. Across phyla, loss of the enzyme responsible for RNA editing, Adar, leads to behavioral changes, impaired locomotion, neurodegeneration ...
Carolina, Maldonado +4 more
openaire +2 more sources
ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity. [PDF]
, 2016 It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the
Dickman, DK +3 more
core