Results 41 to 50 of about 8,355 (219)

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome

Cell Reports, 2015
Little is known about how RNA editing operates in cancer. Transcriptome analysis of 68 normal and cancerous breast tissues revealed that the editing enzyme ADAR acts uniformly, on the same loci, across tissues.
Debora Fumagalli, David Gacquer, Françoise Rothé, Anne Lefort, Frederick Libert, David Brown, Naima Kheddoumi, Adam Shlien, Tomasz Konopka, Roberto Salgado, Denis Larsimont, Kornelia Polyak, Karen Willard-Gallo, Christine Desmedt, Martine Piccart, Marc Abramowicz, Peter J. Campbell, Christos Sotiriou, Vincent Detours   +18 more
doaj   +1 more source

RNA Editing-Dependent and -Independent Roles of Adenosine Deaminases Acting on RNA Proteins in Herpesvirus Infection—Hints on Another Layer of Complexity

Viruses, 2023
The Adenosine Deaminases Acting on RNA (ADAR) catalyze the posttranscriptional deamination of adenosine residues to inosine in double-stranded RNAs (dsRNAs, A-to-I editing), preventing the overactivation of dsRNA sensor molecules and interferons.
Vlatka Ivanišević, Lidia Žilić, Marina Čunko, Hana Fadiga, Ivana Munitić, Igor Jurak   +5 more
doaj   +1 more source

A full repertoire of Hemiptera genomes reveals a multi-step evolutionary trajectory of auto-RNA editing site in insect Adar gene

RNA Biology, 2023
Adenosine-to-inosine (A-to-I) RNA editing, mediated by metazoan ADAR enzymes, is a prevalent post-transcriptional modification that diversifies the proteome and promotes adaptive evolution of organisms. The Drosophila Adar gene has an auto-recoding site (
Ling Ma, Caiqing Zheng, Shiwen Xu, Ye Xu, Fan Song, Li Tian, Wanzhi Cai, Hu Li, Yuange Duan   +8 more
doaj   +1 more source

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins

Biomolecules, 2015
The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Niamh Mannion, Fabiana Arieti, Angela Gallo, Liam P. Keegan, Mary A. O'Connell   +4 more
doaj   +1 more source

Extending adamic adar for cold-start problem in link prediction based on network metrics

IJAIN (International Journal of Advances in Intelligent Informatics), 2022
The cold-start problem is a condition for a new node to join a network with no available information or an isolated node. Most studies use topological network information with the Triadic Closure principles to predict links in future networks.
Herman Yuliansyah, Zulaiha Ali Othman, Azuraliza Abu Bakar   +2 more
doaj   +1 more source

Site-specific regulation of RNA editing with ribose-modified nucleoside analogs in ADAR guide strands. [PDF]

Nucleic Acids Res
Jauregui-Matos V, Jacobs O, Ouye R, Mozumder S, Salvador PJ, Fink KD, Beal PA.   +6 more
europepmc   +3 more sources

ADAR Editing Wobbles the MicroRNA World [PDF]

ACS Chemical Biology, 2007
Recent work reveals that adenosine-to-inosine editing occurs in a number of cellular microRNAs (miRNAs). Such editing is shown to diminish the expression of one miRNA and alter the target specificity of another. This changes our current views significantly by not only increasing the repertoire of miRNAs and their potential targets, but also providing ...
Gordon G. Carmichael, Asis Das
openaire   +3 more sources

Altered ADAR 2 equilibrium and 5HT2CR editing in the prefrontal cortex of ADAR 2 transgenic mice [PDF]

Genes, Brain and Behavior, 2011
Modulation of serotonin signaling by RNA editing of the serotonin 2C receptor (5HT(2C) R) may be relevant to affective disorder as serotonin functions regulate mood and behavior. Previously, we observed enhanced endogenous behavioral despair in ADAR2 transgenic mice.
K. Agassandian, Minati Singh, Alan Kim Johnson, M. B. Zimmerman, Elisa S. Na, M. M. Singh   +5 more
openaire   +3 more sources

Adar Regulates Drosophila melanogaster Spermatogenesis via Modulation of BMP Signaling. [PDF]

Int J Mol Sci
Zhang Q, Fan X, Fu F, Zhu Y, Luo G, Chen H.   +5 more
europepmc   +3 more sources

Global Aspects of Spaces of Vacua [PDF]

, 2020
We study "vacuum crossing", which occurs when the vacua of a theory are exchanged as we vary some periodic parameter $\theta$ in a closed loop. We show that vacuum crossing is a useful non-perturbative tool to study strongly-coupled quantum field theories, since finding vacuum crossing in a weakly-coupled regime of the theory can lead to nontrivial ...
arxiv   +1 more source