Results 61 to 70 of about 40,794 (233)
ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity. [PDF]
, 2016 It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the
Dickman, DK +3 more
core
Link Prediction using Top-$k$ Shortest Distances
, 2017 In this paper, we apply an efficient top-$k$ shortest distance routing algorithm to the link prediction problem and test its efficacy. We compare the results with other base line and state-of-the-art methods as well as with the shortest path. Our results
Lebedev, Andrei +3 more
core +1 more source
Advanced Science, EarlyView.This study reveals that ADAR1, an RNA‐editing enzyme, fine‐tunes immune responses in the placenta by preventing the accumulation of immunogenic double‐stranded RNAs (dsRNAs) from interferon‐stimulated genes. The loss of ADAR1 in the placenta leads to excessive interferon signaling restricted to the junctional zone, disrupting placental development and ...
Xiaogang Chen +7 more
wiley +1 more source
Unveiling RNA Editing by ADAR and APOBEC Protein Gene Families
Frontiers in Bioscience-LandmarkRNA editing is a crucial post-transcriptional modification that alters the transcriptome and proteome and affects many cellular processes, including splicing, microRNA specificity, stability of RNA molecules, and protein structure.
Alexander Modestov +2 more
doaj +1 more source
Molecular Genetics & Genomic Medicine, 2019 Background Dyschromatosis symmetrica hereditaria (DSH;OMIM: #127400) is a rare autosomal dominant skin disease of hyperpigmented and hypopigmented macules on the dorsal aspects of the feet and hands.
Peng Wang +4 more
doaj +1 more source
Alu Overexpression Leads to an Increased Double‐stranded RNA Signature in Dermatomyositis
Arthritis &Rheumatology, Accepted Article.Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the non‐coding genome in disease pathogenesis.
Rayan Najjar +2 more
wiley +1 more source
ADAR Therapeutics as a New Tool for Personalized Medicine. [PDF]
Genes (Basel)In the field of RNA therapy, innovative approaches based on adenosine deaminases acting on RNA (ADAR)-mediated site-directed RNA editing (SDRE) have been established, providing an exciting opportunity for RNA therapeutics. ADAR1 and ADAR2 enzymes are accountable for the predominant form of RNA editing in humans, which involves the hydrolytic ...
Bertoli M, La Via L, Barbon A.
europepmc +3 more sources
Automated data acquisition and reduction system for torsional braid analyzer [PDF]
, 1975 Automated Data Acquisition and Reduction System (ADAR) evaluates damping coefficient and relative rigidity by storing four successive peaks of waveform and time period between two successive peaks.
Carl, G. L. +3 more
core +1 more source
Personalized Degrees: Effects on Link Formation in Dynamic Networks from an Egocentric Perspective
, 2019 Understanding mechanisms driving link formation in dynamic social networks is a long-standing problem that has implications to understanding social structure as well as link prediction and recommendation.
Arastuie, Makan, Xu, Kevin S.
core +1 more source
New insights into applications of base editor in hereditary disorders
Interdisciplinary Medicine, EarlyView.Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai +8 more
wiley +1 more source