Results 61 to 70 of about 43,703 (264)
ADAR Editing Wobbles the MicroRNA World [PDF]
ACS Chemical Biology, 2007 Recent work reveals that adenosine-to-inosine editing occurs in a number of cellular microRNAs (miRNAs). Such editing is shown to diminish the expression of one miRNA and alter the target specificity of another. This changes our current views significantly by not only increasing the repertoire of miRNAs and their potential targets, but also providing ...
Gordon G. Carmichael, Asis Das
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Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR-B R/G site [PDF]
, 2002 RNA editing by members of the ADAR (adenosine deaminase that acts on RNA) enzyme family involves hydrolytic deamination of adenosine to inosine within the context of a double-stranded pre-mRNA substrate.
Collins, Cynthia H. +2 more
core +1 more source
Nature Communications, 2022 Adenosine deaminases (ADARs) catalyze the deamination of adenosine to inosine, also known as A-to-I editing, in RNA. Although A-to-I editing occurs widely across animals and is well studied, new biological roles are still being discovered. Here, we study
K. Nieścierowicz +11 more
semanticscholar +1 more source
DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. [PDF]
, 2017 Adenosine deaminases that act on RNA (ADARs) carry out adenosine (A) to inosine (I) editing reactions with a known requirement for duplex RNA. Here, we show that ADARs also react with DNA/RNA hybrid duplexes.
Beal, Peter A +2 more
core +1 more source
ADAR-Editing during Ostreid Herpesvirus 1 Infection in Crassostrea gigas: Facts and Limitations
Msphere, 2022 Ostreid herpesvirus-1 (OsHV-1) is a harmful pathogen of bivalve species, such as oysters. However, knowledge is lacking about host–virus interactions at the molecular level, hampering the possibility of a correct management of viral outbreaks and related
U. Rosani +3 more
semanticscholar +1 more source
The Role of RNA Editing by ADARs in RNAi [PDF]
Molecular Cell, 2002 Adenosine deaminases that act on RNA (ADARs) are RNA-editing enzymes that deaminate adenosines to create inosines in double-stranded RNA (dsRNA). Here we demonstrate that ADARs are not required for RNA interference (RNAi) and that they do not antagonize the pathway to a detectable level when RNAi is initiated by injecting dsRNA.
Scott W. Knight, Brenda L. Bass
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Altered ADAR 2 equilibrium and 5HT2CR editing in the prefrontal cortex of ADAR 2 transgenic mice [PDF]
Genes, Brain and Behavior, 2011 Modulation of serotonin signaling by RNA editing of the serotonin 2C receptor (5HT(2C) R) may be relevant to affective disorder as serotonin functions regulate mood and behavior. Previously, we observed enhanced endogenous behavioral despair in ADAR2 transgenic mice.
K. Agassandian +5 more
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ADARs have effects beyond RNA editing [PDF]
Cell Cycle, 2009 hairpin-mediated silencing and partially restores the red eye pigment. Inactive ADAR1p150 restored the pigmentation to 40% of ADAR1p150 levels suggesting that binding alone can influence processing of long duplexes into siRNAs. Cleavage by DICER is thought to be affected as this antagonism occurs in the cytoplasm and DICER can partially suppress the ...
Heale, Bret S E +2 more
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T time for
EMBO reports, 2018 ADAR1, an RNA‐editing enzyme, plays a key role in preventing self‐RNAs from triggering autoinflammatory responses. In this issue of EMBO reports , Nakahama and colleagues uncover a novel role for ADAR1 in T cells [1]. The authors report that in T cells, ADAR1‐mediated suppression of type I interferon‐stimulated gene (ISG) expression is required for ...
Hachung Chung, Charles M. Rice
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Global Transcriptome Analysis of RNA Abundance Regulation by ADAR in Lung Adenocarcinoma
EBioMedicine, 2018 Despite tremendous advances in targeted therapies against lung adenocarcinoma, the majority of patients do not benefit from personalized treatments. A deeper understanding of potential therapeutic targets is crucial to increase the survival of patients ...
Michael F. Sharpnack +7 more
doaj +1 more source