Results 61 to 70 of about 42,601 (251)

Seven novel mutations of ADAR in multi‐ethnic pedigrees with dyschromatosis symmetrica hereditaria in China

Molecular Genetics & Genomic Medicine, 2019
Background Dyschromatosis symmetrica hereditaria (DSH;OMIM: #127400) is a rare autosomal dominant skin disease of hyperpigmented and hypopigmented macules on the dorsal aspects of the feet and hands.
Peng Wang, Shirong Yu, Jianyong Liu, Dezhi Zhang, Xiaojing Kang   +4 more
doaj   +1 more source

Link Prediction using Top-$k$ Shortest Distances

, 2017
In this paper, we apply an efficient top-$k$ shortest distance routing algorithm to the link prediction problem and test its efficacy. We compare the results with other base line and state-of-the-art methods as well as with the shortest path. Our results
Lebedev, Andrei, Lee, JooYoung, Mazzara, Manuel, Rivera, Victor   +3 more
core   +1 more source

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

The association of white‐matter integrity with depression‐ symptoms among middle‐aged adults at high risk for Alzheimer's disease and related disorders [PDF]

Alzheimers Dement
Abstract Background Reduced white‐matter integrity, detectable before other brain imaging findings in individuals at risk for Alzheimer's disease and related disorders (ADRD), may underlie both the pathogenesis and consequences of depression. Investigating the relationship between white‐matter integrity and depressive symptoms in middle‐aged ...
Ravona‐Springer R, Vered S, Livny A, Ganmore I, Soleimani L, Shamir T, Almog G, Niv T, Zorani S, Matatov A, Azuri J, Beeri M, Weinstein G.   +12 more
europepmc   +2 more sources

ADAR mediates differential expression of polycistronic microRNAs [PDF]

Nucleic Acids Research, 2014
Adenosine deaminases acting on RNAs (ADARs) convert adenosine residues to inosines in primary microRNA (pri-miRNA) transcripts to alter the structural conformation of these precursors and the subsequent functions of the encoded microRNAs (miRNAs). Here we show that RNA editing by Drosophila ADAR modulates the expression of three co-transcribed miRNAs ...
Chawla, Geetanjali, Sokol, Nicholas S.
openaire   +2 more sources

Automated data acquisition and reduction system for torsional braid analyzer [PDF]

, 1975
Automated Data Acquisition and Reduction System (ADAR) evaluates damping coefficient and relative rigidity by storing four successive peaks of waveform and time period between two successive peaks.
Carl, G. L., Dalal, S. K., Inge, A. T., Johnston, N. J.   +3 more
core   +1 more source

Improved arrayed-waveguide-grating layout avoiding systematic phase errors [PDF]

, 2011
We present a detailed description of an improved arrayed-waveguide-grating (AWG) layout for both, low and high diffraction orders. The novel layout presents identical bends across the entire array; in this way systematic phase errors arising from ...
Driessen, Alfred, Ismail, N., Pollnau, Markus, Ridder, René M. de, Sengo, Gabriël, Sun, Fei, Wörhoff, Kerstin   +6 more
core   +4 more sources

Alu Overexpression Leads to an Increased Double‐Stranded RNA Signature in Dermatomyositis

Arthritis &Rheumatology, EarlyView.
Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the noncoding genome in disease pathogenesis.
Rayan Najjar, Andrew Mammen, Tomas Mustelin   +2 more
wiley   +1 more source

Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs

Genome Biology, 2017
One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes.
Carl R. Walkley, Jin Billy Li
doaj   +1 more source

In vivo RNA editing of point mutations via RNA-guided adenosine deaminases. [PDF]

, 2019
We present in vivo sequence-specific RNA base editing via adenosine deaminases acting on RNA (ADAR) enzymes with associated ADAR guide RNAs (adRNAs). To achieve this, we systematically engineered adRNAs to harness ADARs, and comprehensively evaluated the
Chen, Genghao, Ganesh, Ashwin, Katrekar, Dhruva, Mali, Prashant, Meluzzi, Dario, Shih, Yu-Ru, Varghese, Shyni, Worlikar, Atharv   +7 more
core   +1 more source