Results 81 to 90 of about 43,703 (264)

Mechanistic insights into editing-site specificity of ADARs [PDF]

Proceedings of the National Academy of Sciences, 2012
Adenosine deaminases that act on RNA (ADARs) deaminate adenosines in dsRNA to produce inosines. ADARs are essential in mammals and are particularly important in the nervous system. Altered levels of adenosine-to-inosine (A-to-I) editing are observed in several diseases. The extent to which an adenosine is edited depends on sequence context. Human ADAR2
Ashani Kuttan, Brenda L. Bass
openaire   +3 more sources

Seven novel mutations of ADAR in multi‐ethnic pedigrees with dyschromatosis symmetrica hereditaria in China

Molecular Genetics & Genomic Medicine, 2019
Background Dyschromatosis symmetrica hereditaria (DSH;OMIM: #127400) is a rare autosomal dominant skin disease of hyperpigmented and hypopigmented macules on the dorsal aspects of the feet and hands.
Peng Wang, Shirong Yu, Jianyong Liu, Dezhi Zhang, Xiaojing Kang   +4 more
doaj   +1 more source

Generative machine learning of ADAR substrates for precise and efficient RNA editing

bioRxiv
Adenosine Deaminase Acting on RNA (ADAR) converts adenosine to inosine within certain double-stranded RNA structures. However, ADAR’s promiscuous editing and poorly understood specificity hinder therapeutic applications. We present an integrated approach
Yue Jiang, Lina R. Bagepalli, Bora S. Banjanin, Yiannis A. Savva, Yingxin Cao, Lan Guo, Adrian W. Briggs, Brian Booth, Ronald J. Hause   +8 more
semanticscholar   +1 more source

Phenotypic Characterization of Seven Pediatric Patients Diagnosed With KAT6B‐Related Disorders: Case Series and Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Genitopatellar syndrome (GPS) and Say‐Barber‐Biesecker‐Young‐Simpson Syndrome (SBBYSS) are clinically distinct neurodevelopmental disorders caused by monoallelic pathogenic variants in KAT6B. In some cases, GPS and SBBYSS features can overlap, determining an intermediate phenotype.
Vittorio Maglione, Antonio Pizzuti, Gioia Mastromoro, Eleonora Cresta, Paola Favata, Maria Cristina Digilio, Rossella Capolino, Maria Lisa Dentici, Lorenzo Sinibaldi, Antonio Novelli, Marco Tartaglia, Gianluca Terrin, Viviana Cardilli   +12 more
wiley   +1 more source

RNA editing signature during myeloid leukemia cell differentiation [PDF]

, 2017
Adenosine deaminases acting on RNA (ADARs) are key proteins for hematopoietic stem cell self-renewal and for survival of differentiating progenitor cells. However, their specific role in myeloid cell maturation has been poorly investigated.
A Athanasiadis, A Gallo, AS Shifera, BE Wulff, BJ Liddicoat, BL Bass, C Cenci, C Sundstrom, C Trapnell, C Trapnell, D Laxminarayana, E Picardi, E Picardi, G Camilli, H Aberle, H Li, JB Patterson, JC Hartner, JH Bahn, JM Desterro, Justin M. Thomas, K Nishikura, L Bazak, L Chen, M D'Antonio, M Daigneault, M Higuchi, M Vogler, MA Zipeto, MA Zipeto, N Mannion, N Paz-Yaacov, Q Jiang, Q Wang, Q Wang, R Marcucci, R XuFeng, RA Steinman, RJ Orlowski, S Tomaselli, S Tomaselli, T Hwang, TD Wu, TR Dawson, W Slotkin, Y Li, Y Pinto, YJ Crow, YS Baek   +48 more
core   +2 more sources

ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair

Nature Communications, 2021
The maintenance of genomic stability requires the coordination of multiple cellular tasks upon the appearance of DNA lesions. RNA editing, the post-transcriptional sequence alteration of RNA, has a profound effect on cell homeostasis, but its implication
Sonia Jimeno, Rosario Prados-Carvajal, María Jesús Fernández-Ávila, Sonia Silva, Domenico A Silvestris, Martin Endara-Coll, G. Rodríguez-Real, Judit Domingo-Prim, Fernando Mejías-Navarro, Amador Romero-Franco, S. Jimeno-González, Sonia I. Barroso, V. Cesarini, A. Aguilera, A. Gallo, N. Visa, Pablo Huertas   +16 more
semanticscholar   +1 more source

ADAR mediates differential expression of polycistronic microRNAs [PDF]

Nucleic Acids Research, 2014
Adenosine deaminases acting on RNAs (ADARs) convert adenosine residues to inosines in primary microRNA (pri-miRNA) transcripts to alter the structural conformation of these precursors and the subsequent functions of the encoded microRNAs (miRNAs). Here we show that RNA editing by Drosophila ADAR modulates the expression of three co-transcribed miRNAs ...
Geetanjali Chawla, Nicholas S. Sokol
openaire   +3 more sources

Crisis Management and Resilience Building Through the Women in Red Protest: The Handmaid's Tale Performances in Response to Israel's Judicial Overhaul

Conflict Resolution Quarterly, EarlyView.
ABSTRACT This paper examines the resilience building and public crisis management led by the “Building an Alternative” feminine NGO in Israel during the 2023 mass demonstrations against the judicial overhaul. The proposed judicial overhaul was perceived as a threat to both democratic foundations and women's rights in Israel.
Rachelly Ashwall‐Yakar, Oriana Abboud Armaly, Smadar Bracha, Hadar Hashash   +3 more
wiley   +1 more source

Utilizing AAV-mediated LEAPER 2.0 for programmable RNA editing in non-human primates and nonsense mutation correction in humanized Hurler syndrome mice

Genome Biology, 2023
Background The endogenous adenosine deaminases acting on RNA (ADAR) have been harnessed to facilitate precise adenosine-to-inosine editing on RNAs.
Zongyi Yi, Yanxia Zhao, Zexuan Yi, Yongjian Zhang, Gangbin Tang, Xiaoxue Zhang, Huixian Tang, Wei Zhang, Ying Zhao, Huayuan Xu, Yuyang Nie, Xueqing Sun, Lijun Xing, Lian Dai, Pengfei Yuan, Wensheng Wei   +15 more
doaj   +1 more source

ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity. [PDF]

, 2016
It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the
Dickman, DK, Joiner, WJ, Paluch, J, Robinson, JE   +3 more
core