Results 81 to 90 of about 42,221 (215)

Inhibiting ADAR1‐Mediated Excessive Epigenetic A‐to‐I RNA Editing Improves the Immune Microenvironment and Increases Sensitivity to Immunotherapy in Lung Adenocarcinoma

MedComm, Volume 7, Issue 3, March 2026.
This study investigated the potential of inhibiting ADAR1 which catalyzed excessive A‐to‐I RNA editing as a therapeutic strategy to augment the effectiveness of immunotherapy in LUAD. Mouse models demonstrated that inhibiting ADAR1 in tumor cells significantly improved the immune microenvironment by increasing PD‐L1 expression and CD8+ T‐cell ...
Sihui Wang, Sufei Zheng, Chengming Liu, Chaoqi Zhang, Xinfeng Wang, Zhanyu Wang, Yan Wang, Xiaoli Feng, Qi Xue, Nan Sun, Jie He   +10 more
wiley   +1 more source

Expressional Localization and Functionally Identifying an RNA Editing Enzyme BmADARa of the Silkworm Bombyx mori

Insects, 2020
The most common type of RNA editing in metazoans is the deamination of adenosine into inosine (A-to-I) catalyzed by the adenosine deaminase acting on the RNA (ADAR) family of proteins.
Chongjun Ye, Song Jiang, Meixia Gong, Qin Min, Manli Fan, Junshan Gao, Yan Meng   +6 more
doaj   +1 more source

Heterogeneous RNA editing and influence of ADAR2 on mesothelioma chemoresistance and the tumor microenvironment

Molecular Oncology, 2022
We previously observed increased levels of adenosine‐deaminase‐acting‐on‐dsRNA (Adar)‐dependent RNA editing during mesothelioma development in mice exposed to asbestos.
Ananya Hariharan, Weihong Qi, Hubert Rehrauer, Licun Wu, Manuel Ronner, Martin Wipplinger, Jelena Kresoja‐Rakic, Suna Sun, Lucia Oton‐Gonzalez, Marika Sculco, Véronique Serre‐Beinier, Clément Meiller, Christophe Blanquart, Jean‐François Fonteneau, Bart Vrugt, Jan Hendrik Rüschoff, Isabelle Opitz, Didier Jean, Marc dePerrot, Emanuela Felley‐Bosco   +19 more
doaj   +1 more source

REPAIR - new tool for RNA editing with Cas13 [PDF]

, 2018
Istraživači su nedavno razvili alat REPAIR koji se sastoji od spojene katalitičke domene deaminaze ADAR i katalitički mrtvog Cas13b, iz obitelji proteina Cas13.
Majsec, Petra
core   +2 more sources

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

Lessons from discovery of true ADAR RNA editing sites in a human cell line

BMC Biology, 2023
Background Conversion or editing of adenosine (A) into inosine (I) catalyzed by specialized cellular enzymes represents one of the most common post-transcriptional RNA modifications with emerging connection to disease.
Fang Wang, Huifen Cao, Qiu Xia, Ziheng Liu, Ming Wang, Fan Gao, Dongyang Xu, Bolin Deng, Yong Diao, Philipp Kapranov   +9 more
doaj   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, Volume 2, Issue 1, Page 106-129, March 2026.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Bilateral striatal necrosis caused by ADAR mutations in two siblings with dystonia and freckles-like skin changes that should be differentiated from Leigh syndrome

Folia Neuropathologica, 2016
Pathogenic molecular variants in the ADAR gene are a known cause of rare diseases, autosomal recessive Aicardi- Goutières syndrome type 6, severe infantile encephalopathy with intracranial calcifications and dominant dyschromatosis symmetrica hereditaria,
Dorota Piekutowska-Abramczuk, Hanna Mierzewska, Monika Bekiesińska-Figatowska, Elżbieta Ciara, Joanna Trubicka, Maciej Pronicki, Dariusz Rokicki, Małgorzata Rydzanicz, Rafał Płoski, Ewa Pronicka   +9 more
doaj   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Senescence in Normal Human Dermal Fibroblasts Induces Heterogeneous Fibril Orientation of Type I Collagen Through Downregulation of BMP‐1

Genes to Cells, Volume 31, Issue 2, March 2026.
Senescent fibroblasts construct collagen fibrils, whose orientation is disturbed. We found that senescent fibroblasts downregulate C‐pp cleavage enzymes BMP‐1 and PCPE‐1, which results in downregulation of C‐pp cleavage. This was demonstrated by conducting BMP‐1 knockdown experiments in young fibroblasts, which led to a disturbance in the orientation ...
Koji Moriya, Yuki Shibaike, Katsura Sano, Toshiaki Tanaka   +3 more
wiley   +1 more source