Results 101 to 110 of about 8,922 (205)

Genesis of ancestral haplotypes: RNA modifications and reverse transcription–mediated polymorphisms [PDF]

, 2011
Understanding the genesis of the block haplotype structure of the genome is a major challenge. With the completion of the sequencing of the Human Genome and the initiation of the HapMap project the concept that the chromosomes of the mammalian genome are
Carnegie, P., Dawkins, R.L., Lester, S., Lindley, R.A., Millman, J.A., Pain, G.N., Steele, E.J., Stewart, B.J., Williamson, J.F.   +8 more
core   +2 more sources

An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation

Cell Reports
Summary: Adar null mutant mouse embryos die with aberrant double-stranded RNA (dsRNA)-driven interferon induction, and Adar Mavs double mutants, in which interferon induction is prevented, die soon after birth.
Ketty Sinigaglia, Anna Cherian, Qiupei Du, Valentina Lacovich, Dragana Vukić, Janka Melicherová, Pavla Linhartova, Lisa Zerad, Stanislav Stejskal, Radek Malik, Jan Prochazka, Nadège Bondurand, Radislav Sedláček, Mary A. O’Connell, Liam P. Keegan   +14 more
doaj   +1 more source

Active Ebola Virus Replication and Heterogeneous Evolutionary Rates in EVD Survivors [PDF]

, 2018
Summary: Following cessation of continuous Ebola virus (EBOV) transmission within Western Africa, sporadic EBOV disease (EVD) cases continued to re-emerge beyond the viral incubation period.
Alfson, Arias, Baczko, Barnes, Bass, Bausch, Blackley, Calain, Cattaneo, Christie, Deen, Dejucq, Delwart, Diallo, Dudas, Duffy, George, Gire, Gupta, Gélinas, Iizasa, Jacobs, Kumar, Kuming, Ladner, Li, Martini, Martínez, Mate, Meyer, Meyer, Ni, Park, Pfaller, Pillai, Randall, Rice, Rodriguez, Rowe, Shabman, Simon-Loriere, Sissoko, Sissoko, Smits, Soka, Spengler, Suspène, Tapia, Tong, Uyeki, Varkey, Volchkova, Zahn   +52 more
core   +2 more sources

Movement Disorders Presenting in Childhood. [PDF]

, 2016
PURPOSE OF REVIEW: This article provides an overview of movement disorders that present in childhood. Key clinical features are discussed, and a brief guide to management strategies is provided.
Dale, RC, Kurian, MA
core   +1 more source

Deep Brain Stimulation in a Child with Aicardi‐Goutières Syndrome‐7 (AGS7): A Case Report and Literature Review

Movement Disorders Clinical Practice, Volume 12, Issue 12, Page 2375-2378, December 2025.
Sangeetha Yoganathan, Siddharth Seth, Sunita Venkateswaran, Wei Kang Lim, Andrea LeBlanc‐Millar, Sara Breitbart, Vivek Pai, Asif Doja, Alfonso Fasano, George M. Ibrahim, Carolina Gorodetsky   +10 more
wiley   +1 more source

Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome. [PDF]

, 2015
Aicardi-Goutières syndrome (AGS) is a severe childhood inflammatory disorder that shows clinical and genetic overlap with systemic lupus erythematosus (SLE).
Chédin, Frédéric, Hartono, Stella R, Lim, Yoong Wearn, Sanz, Lionel A, Xu, Xiaoqin   +4 more
core   +2 more sources

ADAR1 may be involved in the proliferation of acute myeloid leukemia cells via regulation of the Wnt pathway

Cancer Management and Research, 2019
Han Xiao, Qian Cheng, Xinyu Wu, Yishu Tang, Jing Liu, Xin Li Department of Hematology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ChinaCorrespondence: Xin Li; Jing LiuDepartment of Hematology, The ...
Xiao H, Cheng Q, Wu X, Tang Y, Liu J, Li X   +5 more
doaj  

A tale of two pathways: Two distinct mechanisms of ADAR1 prevent fatal autoinflammation [PDF]

, 2023
Tyler J. Dorrity, Hachung Chung
openalex   +1 more source

Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line

eLife, 2017
ADAR1 isoforms are adenosine deaminases that edit and destabilize double-stranded RNA reducing its immunostimulatory activities. Mutation of ADAR1 leads to a severe neurodevelopmental and inflammatory disease of children, Aicardi-Goutiéres syndrome.
Yize Li, Shuvojit Banerjee, Stephen A Goldstein, Beihua Dong, Christina Gaughan, Sneha Rath, Jesse Donovan, Alexei Korennykh, Robert H Silverman, Susan R Weiss   +9 more
doaj   +1 more source

REPAIR - new tool for RNA editing with Cas13 [PDF]

, 2018
Istraživači su nedavno razvili alat REPAIR koji se sastoji od spojene katalitičke domene deaminaze ADAR i katalitički mrtvog Cas13b, iz obitelji proteina Cas13.
Majsec, Petra
core   +2 more sources