Results 11 to 20 of about 8,922 (205)

RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain.

PLoS Genetics, 2021
Adenosine deaminase acting on RNA 1 (ADAR1), an enzyme responsible for adenosine-to-inosine RNA editing, is composed of two isoforms: nuclear p110 and cytoplasmic p150.
Jung In Kim, Taisuke Nakahama, Ryuichiro Yamasaki, Pedro Henrique Costa Cruz, Tuangtong Vongpipatana, Maal Inoue, Nao Kanou, Yanfang Xing, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara   +11 more
doaj   +1 more source

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation

Frontiers in Endocrinology, 2022
IntroductionEnterovirus infection has long been suspected as a possible trigger for type 1 diabetes. Upon infection, viral double-stranded RNA (dsRNA) is recognized by membrane and cytosolic sensors that orchestrate type I interferon signaling and the ...
Florian Szymczak, Roni Cohen-Fultheim, Sofia Thomaidou, Alexandra Coomans de Brachène, Angela Castela, Maikel Colli, Piero Marchetti, Erez Levanon, Decio Eizirik, Arnaud Zaldumbide   +9 more
doaj   +1 more source

Expression and clinical significance of adenosine deaminase acting on RNA-1 in lung adenocarcinoma

Di-san junyi daxue xuebao, 2021
Objective To investigate the expression of adenosine deaminase acting on RNA-1 (ADAR1) in lung adenocarcinoma and its association with clinicopathological characteristics and prognosis.
YANG Wendi, YU Qian, GUO Zhengjun, PENG Yuan, YANG Zhenzhou   +4 more
doaj   +1 more source

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

Cell Reports, 2021
Summary: Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS). ADAR1 converts adenosines into inosines within dsRNA. This process called A-to-I
Richard de Reuver, Evelien Dierick, Bartosz Wiernicki, Katrien Staes, Leen Seys, Ellen De Meester, Tuur Muyldermans, Alexander Botzki, Bart N. Lambrecht, Filip Van Nieuwerburgh, Peter Vandenabeele, Jonathan Maelfait   +11 more
doaj   +1 more source

ADAR1 has an oncogenic function and can be a prognostic factor in cervical cancer

Scientific Reports, 2023
Adenosine deaminase acting on RNA 1 (ADAR1), a recently described epigenetic modifier, is believed to play a critical oncogenic role in human cancers. However, its functional role and clinical significance in cervical cancer (CC) remain unclear.
Keiichiro Nakamura, Kunitoshi Shigeyasu, Kazuhiro Okamoto, Hirofumi Matsuoka, Hisashi Masuyama   +4 more
doaj   +1 more source

ADAR1 promotes systemic sclerosis via modulating classic macrophage activation

Frontiers in Immunology, 2022
IntroductionAs a multisystem autoimmune disorder disease, systemic sclerosis (SSc) is characterized by inflammation and fibrosis in the skin and other internal organs.
Chenming Sun, Chenming Sun, Chenming Sun, Dunpeng Cai, Shi-You Chen, Shi-You Chen   +5 more
doaj   +1 more source

Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis

Genome Biology, 2017
Background Adenosine-to-inosine (A-to-I) editing of dsRNA by ADAR proteins is a pervasive epitranscriptome feature. Tens of thousands of A-to-I editing events are defined in the mouse, yet the functional impact of most is unknown. Editing causing protein
Jacki E. Heraud-Farlow, Alistair M. Chalk, Sandra E. Linder, Qin Li, Scott Taylor, Joshua M. White, Lokman Pang, Brian J. Liddicoat, Ankita Gupte, Jin Billy Li, Carl R. Walkley   +10 more
doaj   +1 more source

ADAR1 is a prognostic biomarker and is correlated with immune infiltration in lung adenocarcinoma

Cancer Medicine, 2023
Background Lung adenocarcinoma (LUAD) is a common subtype of non‐small cell lung cancer with high morbidity and mortality rates and is usually detected at advanced stages because of the early onset of metastasis. Adenosine deaminase RNA‐specific 1 (ADAR1)
Wendi Yang, Kehong Chen, Qian Yu, Rongxin Liao, Hengqiu He, Yuan Peng, Zhenzhou Yang, Xiaoyue Zhang   +7 more
doaj   +1 more source

ADAR1 Alleviates Inflammation in a Murine Sepsis Model via the ADAR1-miR-30a-SOCS3 Axis

Mediators of Inflammation, 2020
Adenosine deaminase acting on double-stranded RNA 1 (ADAR1) mediates adenosine-to-inosine (A-to-I) RNA editing events. ADAR1 is highly expressed in “septic” macrophages and in small intestinal tissues of mice with sepsis.
Zhou Shangxun, Li Junjie, Zhao Wei, Wang Yutong, Jia Wenyuan, Liu Shanshou, Wang Yanjun, Wang Qianmei, Feng Zhusheng, Yu Chaoping, Zhuang Ran, Yin Wen, Huang Yang   +12 more
doaj   +1 more source

ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal-Fetal Interface. [PDF]

Adv Sci (Weinh)
This study reveals that ADAR1, an RNA‐editing enzyme, fine‐tunes immune responses in the placenta by preventing the accumulation of immunogenic double‐stranded RNAs (dsRNAs) from interferon‐stimulated genes. The loss of ADAR1 in the placenta leads to excessive interferon signaling restricted to the junctional zone, disrupting placental development and ...
Chen X, Xu X, Chen J, Zhang H, Zheng W, Yu W, Hu X, Cao B.   +7 more
europepmc   +2 more sources