Results 11 to 20 of about 7,998 (203)

ADAR1 restricts LINE-1 retrotransposition [PDF]

Nucleic Acids Research, 2016
Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosines to inosines in double-stranded RNAs. ADAR1 was demonstrated to be functional on different viruses exerting either antiviral or proviral effects.
Antonioni, Ambra, Ciafré, Silvia Anna, Doria, Margherita, Frassinelli, Loredana, Galardi, Silvia, Mancone, Carmine, Michienzi, Alessandro, Montaldo, Claudia, Orecchini, Elisa, Tripodi, Marco   +9 more
core   +6 more sources

ADAR1 Alleviates Inflammation in a Murine Sepsis Model via the ADAR1-miR-30a-SOCS3 Axis

Mediators of Inflammation, 2020
Adenosine deaminase acting on double-stranded RNA 1 (ADAR1) mediates adenosine-to-inosine (A-to-I) RNA editing events. ADAR1 is highly expressed in “septic” macrophages and in small intestinal tissues of mice with sepsis.
Zhou Shangxun, Li Junjie, Zhao Wei, Wang Yutong, Jia Wenyuan, Liu Shanshou, Wang Yanjun, Wang Qianmei, Feng Zhusheng, Yu Chaoping, Zhuang Ran, Yin Wen, Huang Yang   +12 more
doaj   +3 more sources

ADAR1 promotes systemic sclerosis via modulating classic macrophage activation

Frontiers in Immunology, 2022
IntroductionAs a multisystem autoimmune disorder disease, systemic sclerosis (SSc) is characterized by inflammation and fibrosis in the skin and other internal organs.
Chenming Sun, Chenming Sun, Chenming Sun, Dunpeng Cai, Shi-You Chen, Shi-You Chen   +5 more
doaj   +3 more sources

ADAR1-Mediated RNA Editing and Its Role in Cancer

Frontiers in Cell and Developmental Biology, 2022
It is well known that the stability of RNA, the interaction between RNA and protein, and the correct translation of protein are significant forces that drive the transition from normal cell to malignant tumor.
Jizhe Liu, Jizhe Liu, Jizhe Liu, Fei Wang, Fei Wang, Yindan Zhang, Yindan Zhang, Yindan Zhang, Jingfeng Liu, Bixing Zhao, Bixing Zhao   +10 more
doaj   +3 more sources

Inhibiting ADAR1-Mediated Excessive Epigenetic A-to-I RNA Editing Improves the Immune Microenvironment and Increases Sensitivity to Immunotherapy in Lung Adenocarcinoma. [PDF]

MedComm (2020)
This study investigated the potential of inhibiting ADAR1 which catalyzed excessive A‐to‐I RNA editing as a therapeutic strategy to augment the effectiveness of immunotherapy in LUAD. Mouse models demonstrated that inhibiting ADAR1 in tumor cells significantly improved the immune microenvironment by increasing PD‐L1 expression and CD8+ T‐cell ...
Wang S, Zheng S, Liu C, Zhang C, Wang X, Wang Z, Wang Y, Feng X, Xue Q, Sun N, He J.   +10 more
europepmc   +2 more sources

The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms [PDF]

, 2021
AbstractAdenosine deaminase acting on RNA (ADAR) (also known as ADAR1) promotes A-to-I conversion in double-stranded and highly structured RNAs. ADAR1 has two isoforms transcribed from different promoters: ADAR1p150, which is mainly cytoplasmic and interferon-inducible, and constitutively expressed ADAR1p110 that is primarily localized in the nucleus ...
Renata Kleinova, Alina F. Leuchtenberger, Claudio Lo Giudice, Andrea Tanzer, Sophia Derdak, Ernesto Picardi, Michael F. Jantsch   +6 more
openaire   +1 more source

The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms

Nucleic Acids Research, 2023
Abstract Adenosine deaminase acting on RNA ADAR1 promotes A-to-I conversion in double-stranded and structured RNAs. ADAR1 has two isoforms transcribed from different promoters: cytoplasmic ADAR1p150 is interferon-inducible while ADAR1p110 is constitutively expressed and primarily localized in the nucleus.
Kleinova, Renata, Rajendra, Vinod, Leuchtenberger, Alina F, Lo Giudice, Claudio, Vesely, Cornelia, Kapoor, Utkarsh, Tanzer, Andrea, Derdak, Sophia, Picardi, Ernesto, Jantsch, Michael F   +9 more
openaire   +4 more sources

Dimerization of ADAR1 modulates site-specificity of RNA editing

Nature Communications
Adenosine-to-inosine editing is catalyzed by adenosine deaminases acting on RNA (ADARs) in double-stranded RNA (dsRNA) regions. Although three ADARs exist in mammals, ADAR1 is responsible for the vast majority of the editing events and acts on thousands ...
Allegra Mboukou, Vinod Rajendra, Serafina Messmer, Therese C. Mandl, Marjorie Catala, Carine Tisné, Michael F. Jantsch, Pierre Barraud   +7 more
doaj   +3 more sources

ADAR1-mediated regulation of melanoma invasion [PDF]

Nature Communications, 2018
AbstractMelanoma cells use different migratory strategies to exit the primary tumor mass and invade surrounding and subsequently distant tissues. We reported previously that ADAR1 expression is downregulated in metastatic melanoma, thereby facilitating proliferation.
Yael Nemlich, Erez Nissim Baruch, Michal Judith Besser, Einav Shoshan, Menashe Bar-Eli, Liat Anafi, Iris Barshack, Jacob Schachter, Rona Ortenberg, Gal Markel   +9 more
openaire   +3 more sources

Substrate recognition by ADAR1 and ADAR2 [PDF]

RNA, 2001
RNA editing catalyzed by ADAR1 and ADAR2 involves the site-specific conversion of adenosine to inosine within imperfectly duplexed RNA. ADAR1- and ADAR2-mediated editing occurs within transcripts of glutamate receptors (GluR) in the brain and in hepatitis delta virus (HDV) RNA in the liver.
S K, Wong, S, Sato, D W, Lazinski
openaire   +2 more sources