Results 51 to 60 of about 8,922 (205)

Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis [PDF]

, 2018
Background Paraspeckles are subnuclear bodies assembled on a long non-coding RNA (lncRNA) NEAT1. Their enhanced formation in spinal neurons of sporadic amyotrophic lateral sclerosis (ALS) patients has been reported but underlying mechanisms are unknown ...
Tatyana A. Shelkovnikova, Michail S. Kukharsky, Haiyan An, Pasquale Dimasi, Svetlana Alexeeva, Osman Shabir, Paul R. Heath, Vladimir L. Buchman, AE Renton, M DeJesus-Hernandez, J Sreedharan, S Lattante, M Neumann, T Arai, AH Fox, T Naganuma, CM Clemson, S Hennig, H Sunwoo, T Hirose, K Imamura, Z Zhang, L Jiang, H Choudhry, D Chakravarty, C Adriaens, Y Nishimoto, S Nakagawa, S Thomas-Jinu, TA Shelkovnikova, A Chesi, HJ Kim, JR Tollervey, M Polymenidou, MS Kukharsky, L Cong, TA Shelkovnikova, AE Renton, Y Kawahara, E Buratti, H Ota, M Morlando, GS Tan, C Lagier-Tourenne, TK Saldi, E White, SR Heras, BJ Liddicoat, F Weber, H Kaneko, M Marullo, SJ Marciniak, GJ Seo, LL Chen, S Melo, G Shan, A Emde, IE Schor, T Misteli, T Yamazaki, C Figueroa-Romero, A Freischmidt, E Gascon, EF Goodall, C Eitan, D Campos-Melo, S Bottini, A Heyam, V Tarallo, NM Mannion, A Ruggieri, S Porta, W Li, TP Hurst, KB Chiappinelli, RA Elbarbary, G Barry, F Zhang, JA West   +78 more
core   +3 more sources

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

Role of ADAR1 on Proliferation and Differentiation in Porcine Preadipocytes

Animals
Recent research has identified ADAR1 as a participant in the regulation of lipid accumulation in mice. However, there are no reports on the roles of ADAR1 in proliferation, apoptosis and differentiation of porcine preadipocytes.
Menghuan Yang, Jun Jiang, Ruimin Ren, Ning Gao, Jun He, Yuebo Zhang   +5 more
doaj   +1 more source

ADAR1 exacerbates ischemic brain injury via astrocyte-mediated neuron apoptosis

Redox Biology, 2023
Astrocytes affect stroke outcomes by acquiring functionally dominant phenotypes. Understanding molecular mechanisms dictating astrocyte functional status after brain ischemia/reperfusion may reveal new therapeutic strategies.
Dunpeng Cai, Mikayla Fraunfelder, Ken Fujise, Shi-You Chen   +3 more
doaj   +1 more source

Differential Enzymatic Activity of Rat ADAR2 Splicing Variants Is Due to Altered Capability to Interact with RNA in the Deaminase Domain [PDF]

, 2018
In mammals, adenosine (A) to inosine (I) RNA editing is performed by adenosine deaminases acting on RNA (ADAR), ADAR1 and ADAR2 enzymes, encoded by mRNAs that might undergo splicing process.
Barbon, Alessandro, Bonini, Daniela, Colombi, Marina, Filippini, Alice, Gangemi, Fabrizio, Giacopuzzi, Edoardo, La Via, Luca   +6 more
core   +2 more sources

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]

, 2020
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien, de Reuver, Richard, Declercq, Wim, Devos, Michael, Dierick, Evelien, Gilbert, Barbara, Lefebvre, Sylvie, Maelfait, Jonathan, Nemegeer, Josephine, Rehwinkel, Jan, Tanghe, Giel, Vandenabeele, Peter, Verheirstraeten, Maud   +12 more
core   +2 more sources

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

Advanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang, Dongpeng Jiang, Peng Ke, Xiaosen Bian, Lili Zhang, Ying Zhang, Tingting Zhu, Weiwei Qu, Wenhui Qi, Yang Xu, Chengcheng Fu, Depei Wu, Jianhong Chu   +12 more
wiley   +1 more source

ADAR1: a central regulator of dsRNA sensing in host-virus interactions

Frontiers in Immunology
Adenosine deaminase acting on RNA 1 (ADAR1) is a key regulator of RNA homeostasis and innate immunity through its adenosine-to-inosine (A-to-I) editing of double-stranded RNAs (dsRNAs).
Congnuan Liu, Younho Choi
doaj   +1 more source

Assessment of Type I Interferon Signaling in Pediatric Inflammatory Disease [PDF]

, 2017
International audiencePURPOSE: Increased type I interferon is considered relevant to the pathology of a number of monogenic and complex disorders spanning pediatric rheumatology, neurology, and dermatology.
A Brehm, AL Mathieu, Alexandre Belot, Anthony Oojageer, Brigitte Bader-Meunier, CD Conrad, Christine Bodemer, D Tonduti, DM Santer, E Lausch, EC Baechler, EC Baechler, F Allantaz, F Goutieres, GI Rice, GI Rice, GI Rice, GI Rice, Gillian I. Rice, Isabelle Melki, J Hua, JH Livingston, L Bennett, M Berger Rentsch, M Henneke, MA Jang, Marie-Louise Frémond, Mathieu P. Rodero, ME Meuwissen, MP Rodero, Naoki Kitabayashi, P Lebon, P Navon Elkan, P Quartier, P Starokadomskyy, Pierre Quartier, PK Chakraborty, Q Zhou, R Banchereau, S Oon, SA Greenberg, SC Eckard, SM Al-Mayouf, TA Briggs, TB Niewold, Tracy A. Briggs, V Sisirak, X Zhang, Y Li, Y Liu, Yanick J. Crow, YJ Crow, YJ Crow, YJ Crow, YJ Crow, YJ Seo   +55 more
core   +4 more sources

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source