Results 61 to 70 of about 8,922 (205)
Biosensors and Bioelectronics: XHuman adenosine deaminase acting on RNA1 (ADAR1) is an adenosine-to-inosine (A-to-I) RNA-editing enzyme involved in various types of cancer progression. ADAR1 has emerged as a novel prognostic biomarker for cancer. This study describes the application of
Madhu Biyani +6 more
doaj +1 more source
An extra double-stranded RNA binding domain confers high activity to a squid RNA editing enzyme [PDF]
, 2009 RNA editing by adenosine deamination is particularly prevalent in the squid nervous system. We hypothesized that the squid editing enzyme might contain structural differences that help explain this phenomenon. As a first step, a squid adenosine deaminase
O'Connell, Mary A +2 more
core +2 more sources
British Journal of Pharmacology, EarlyView.Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang +18 more
wiley +1 more source
ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress
Drug Design, Development and Therapy, 2018 Yun Jiang,1 Zhancheng Wang,1 Xu Chen,1 Wei Wang,1 Xiaowei Wang2 1Department of Cardiology, The Eighth People’s Hospital of Shanghai, Shanghai 200233, China; 2Shanghai Weiang Info Tech Ltd., Shanghai 200233, China Background: The adenosine ...
Jiang Y, Wang Z, Chen X, Wang W, Wang X
doaj
Zalpha-domains: At the intersection between RNA editing and innate immunity [PDF]
, 2012 The involvement of A to I RNA editing in antiviral responses was first indicated by the observation of genomic hyper-mutation for several RNA viruses in the course of persistent infections.
Athanasiadis, Alekos
core +1 more source
Adenosine Deaminase Acting on RNA1 (ADAR1) Deficiency Promotes Proliferation of Hemangioma-Derived Endothelial Cells via PI3K/Akt/mTOR Pathway [PDF]
, 2023 Chaoqi Yin +3 more
openalex +1 more source
EIF4A3‐Induced Circular RNA circSnd1 Promotes Muscle Atrophy and Muscle Ageing by Stabilizing EEF1A1
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Background Muscle atrophy is a common complication of ageing, and many chronic conditions, lacks defined therapeutic interventions. It is still mostly unknown how circular RNAs contribute to muscle atrophy. Methods circRNA sequencing and quantitative real‐time PCR were performed to detect the changed circRNAs in muscle atrophy models and aged ...
Jin Li +21 more
wiley +1 more source
Experimental Hematology & OncologyBackground A-to-I RNA editing is an abundant post-transcriptional modification event in hepatocellular carcinoma (HCC). Evidence suggests that adenosine deaminases acting on RNA 1 (ADAR1) correlates to oxidative stress that is a crucial factor of HCC ...
Houhong Wang +4 more
doaj +1 more source
The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication [PDF]
, 2014 Most RNA viruses infecting mammals and other vertebrates show profound suppression of CpG and UpA dinucleotide frequencies. To investigate this functionally, mutants of the picornavirus, echovirus 7 (E7), were constructed with altered CpG and UpA ...
Atkinson, Nicky J. +3 more
core +2 more sources
MedComm, Volume 7, Issue 2, February 2026.Increased miR‐3163 targets NUDT21, reducing CPSF5 levels and driving APA dysregulation. This results in 3′UTR shortening of CBFB, which stabilizes RUNX1 and promotes smooth muscle proliferation. PTGER3, is also shortened amplifying hypoxia‐induced RVSP. Together, these pathways contribute to vascular remodeling in PH. Image Created in https://BioRender.
Scott D. Collum +17 more
wiley +1 more source