Diverse selective regimes shape genetic diversity atADARgenes and at their coding targets [PDF]
RNA Biology, 2015 A-to-I RNA editing operated by ADAR enzymes is extremely common in mammals. Several editing events in coding regions have pivotal physiological roles and affect protein sequence (recoding events) or function. We analyzed the evolutionary history of the 3 ADAR family genes and of their coding targets.
Diego Forni +9 more
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Functional Impact of RNA editing and ADARs on regulation of gene expression: perspectives from deep sequencing studies [PDF]
Cell & Bioscience, 2014 Cells regulate gene expression at multiple levels leading to a balance between robustness and complexity within their proteome. One core molecular step contributing to this important balance during metazoan gene expression is RNA editing, such as the co-transcriptional recoding of RNA transcripts catalyzed by the adenosine deaminse acting on RNA (ADAR)
Hsuan Liu +5 more
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An RNA editing/binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer [PDF]
, 2016 AbstractAdenosine-to-inosine (A-to-I) editing, catalysed by Adenosine DeAminases acting on double-stranded RNA (dsRNA) (ADAR), occurs predominantly in the 3’ untranslated regions (3’UTRs). Here we uncover an unanticipated link between ADARs (ADAR1 and ADAR2) and the expression of target genes undergoing extensive 3’UTR editing.
Lihua Qi +11 more
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PLOS Biology, 2023 The ability to alter gene expression programs in response to changes in environmental conditions is central to the ability of an organism to thrive. For most organisms, the nervous system serves as the master regulator in communicating information about the animal’s surroundings to other tissues.
Ananya Mahapatra +4 more
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Induction of 150‐kDa adenosine deaminase that acts on RNA (ADAR)‐1 gene expression in normal T lymphocytes by anti‐CD3‐ε and anti‐CD28 [PDF]
Immunology, 2007 SummaryWe and other investigators have demonstrated up‐regulation of the expression of the RNA‐editing gene 150‐kDa adenosine deaminase that acts on RNA (ADAR1) in systemic lupus erythematosus (SLE) T cells and B cells, peripheral blood mononuclear cells (PBMC), natural killer (NK) cells.
Dama Laxminarayana +3 more
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SAGE: Sequential Attribute Generator for Analyzing Glioblastomas using Limited Dataset
, 2020 While deep learning approaches have shown remarkable performance in many imaging tasks, most of these methods rely on availability of large quantities of data. Medical image data, however, is scarce and fragmented.
Allen, Jason +5 more
core
BMC MedicineBackground Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive ages. Our previous study has implicated a possible link between RNA editing and PCOS, yet the actual role of RNA editing, its association with ...
Fan-Sheng Kong +9 more
doaj +1 more source
Adaptive evolution of A-to-I auto-editing site in Adar of eusocial insects
BMC GenomicsBackground Adenosine-to-inosine (A-to-I) RNA editing is a co-/post-transcriptional modification introducing A-to-G variations in RNAs. There is extensive discussion on whether the flexibility of RNA editing exerts a proteomic diversification role, or it ...
Caiqing Zheng, Jiyao Liu, Yuange Duan
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The role of RNA editing in cancer development and metabolic disorders [PDF]
, 2018 Kung, Che-Pei +2 more
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Integrative PANoptosis gene profiling reveals prognostic and therapeutic insights in prostate cancer
Biomolecules & BiomedicineProstate cancer (PCa) remains a significant global health challenge, representing the most common solid tumor in men and the fifth leading cause of cancer-related death. Despite therapeutic advances, achieving a definitive cure remains difficult.
Yi Wang +8 more
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