Results 1 to 10 of about 6,398,385 (224)
A full repertoire of Hemiptera genomes reveals a multi-step evolutionary trajectory of auto-RNA editing site in insect Adar gene [PDF]
RNA Biology, 2023 Adenosine-to-inosine (A-to-I) RNA editing, mediated by metazoan ADAR enzymes, is a prevalent post-transcriptional modification that diversifies the proteome and promotes adaptive evolution of organisms. The Drosophila Adar gene has an auto-recoding site (termed S>G site) that forms a negative-feedback loop and stabilizes the global editing activity.
Ling Ma +8 more
doaj +6 more sources
Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene [PDF]
EpigeneticsAlthough A-to-I RNA editing leads to similar effects to A-to-G DNA mutation, nonsynonymous RNA editing (recoding) is believed to confer its adaptiveness by 'epigenetically' regulating proteomic diversity in a temporospatial manner, avoiding the pleiotropic effect of genomic mutations.
Caiqing Zheng +6 more
doaj +7 more sources
The origin of the ADAR gene family and animal RNA editing [PDF]
BMC Evolutionary Biology, 2015 ADAR (adenosine deaminase acting on RNA) proteins convert adenosine into inosine in double-stranded RNAs and have been shown to increase gene product diversity in a number of bilaterians, particularly mammals and flies. This enzyme family appears to have evolved from an ADAT (adenosine deaminase acting on tRNA) ancestor, via the addition of a double ...
Laura F. Grice, Bernard M. Degnan
semanticscholar +9 more sources
Unveiling RNA Editing by ADAR and APOBEC Protein Gene Families
Frontiers in Bioscience-LandmarkRNA editing is a crucial post-transcriptional modification that alters the transcriptome and proteome and affects many cellular processes, including splicing, microRNA specificity, stability of RNA molecules, and protein structure. Enzymes from the adenosine deaminase acting on RNA (ADAR) and apolipoprotein B mRNA editing catalytic polypeptide-like ...
Alexander Modestov +2 more
doaj +6 more sources
ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression [PDF]
Cell Reports, 2013 Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine, which is then recognized as guanosine. To study the role of ADAR proteins in RNA editing and gene regulation, we sequenced and compared the DNA and RNA of human B cells. Then, we followed up the findings experimentally with siRNA knockdown and RNA and protein immunoprecipitations.
Isabel X. Wang +5 more
doaj +5 more sources
All I's on the
FEBS Letters, 2018 Adenosine to inosine (A‐to‐I) editing is the most abundant form of RNA modification in mammalian cells, which is catalyzed by adenosine deaminase acting on the double‐stranded RNA (ADAR) protein family. A‐to‐I editing is currently known to be involved in the regulation of the immune system, RNA splicing, protein recoding, microRNA biogenesis, and ...
Galina Shevchenko, Kevin V. Morris
semanticscholar +6 more sources
Diverse selective regimes shape genetic diversity atADARgenes and at their coding targets [PDF]
RNA Biology, 2015 A-to-I RNA editing operated by ADAR enzymes is extremely common in mammals. Several editing events in coding regions have pivotal physiological roles and affect protein sequence (recoding events) or function. We analyzed the evolutionary history of the 3 ADAR family genes and of their coding targets.
Diego Forni +9 more
openalex +4 more sources
ADBP-1 Regulates an ADAR RNA-Editing Enzyme to Antagonize RNA-Interference-Mediated Gene Silencing inCaenorhabditis elegans [PDF]
Genetics, 2008 Abstract Small interfering RNAs (siRNAs) and microRNAs (miRNAs) mediate gene silencing through evolutionarily conserved pathways. In Caenorhabditis elegans, the siRNA/miRNA pathways are also known to affect transgene expression. To identify genes that regulate the efficiencies of the siRNA/miRNA pathways, we used the expression level of ...
Hiromitsu Ohta +3 more
openalex +5 more sources
Caenorhabditis elegans mRNAs that encode a protein similar to ADARs derive from an operon containing six genes [PDF]
Nucleic Acids Research, 1999 The Caenorhabditis elegans T20H4.4 open reading frame (GenBank accession no. U00037) predicted by Genefinder encodes a 367 amino acid protein that is 32-35% identical to the C-terminal domain of adenosine deaminases that act on RNA. We show that T20H4.4 cDNAs (GenBank accession no.
R Hough, Arunth T. Lingam, Brenda Bass
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Functional Impact of RNA editing and ADARs on regulation of gene expression: perspectives from deep sequencing studies [PDF]
Cell & Bioscience, 2014 Cells regulate gene expression at multiple levels leading to a balance between robustness and complexity within their proteome. One core molecular step contributing to this important balance during metazoan gene expression is RNA editing, such as the co-transcriptional recoding of RNA transcripts catalyzed by the adenosine deaminse acting on RNA (ADAR)
Hsuan Liu +5 more
openalex +5 more sources