A full repertoire of Hemiptera genomes reveals a multi-step evolutionary trajectory of auto-RNA editing site in insect Adar gene [PDF]
RNA Biology, 2023 Adenosine-to-inosine (A-to-I) RNA editing, mediated by metazoan ADAR enzymes, is a prevalent post-transcriptional modification that diversifies the proteome and promotes adaptive evolution of organisms. The Drosophila Adar gene has an auto-recoding site (
Ling Ma +8 more
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Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene [PDF]
EpigeneticsAlthough A-to-I RNA editing leads to similar effects to A-to-G DNA mutation, nonsynonymous RNA editing (recoding) is believed to confer its adaptiveness by ‘epigenetically’ regulating proteomic diversity in a temporospatial manner, avoiding the ...
Caiqing Zheng +6 more
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Autorecoding A-to-I RNA editing sites in the Adar gene underwent compensatory gains and losses in major insect clades. [PDF]
RNA, 2023 As one of the most prevalent RNA modifications in animals, adenosine-to-inosine (A-to-I) RNA editing facilitates the environmental adaptation of organisms by diversifying the proteome in a temporal–spatial manner.
Duan Y +5 more
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The origin of the ADAR gene family and animal RNA editing. [PDF]
BMC Evol Biol, 2015 BackgroundADAR (adenosine deaminase acting on RNA) proteins convert adenosine into inosine in double-stranded RNAs and have been shown to increase gene product diversity in a number of bilaterians, particularly mammals and flies.
Grice LF, Degnan BM.
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Unveiling RNA Editing by ADAR and APOBEC Protein Gene Families [PDF]
Frontiers in Bioscience-LandmarkRNA editing is a crucial post-transcriptional modification that alters the transcriptome and proteome and affects many cellular processes, including splicing, microRNA specificity, stability of RNA molecules, and protein structure.
Alexander Modestov +2 more
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Adar contributes to genome integrity by regulating R-loop homeostasis in Drosophila [PDF]
BMC BiologyBackground Adenosine deaminase acting on RNA (Adar) is a critical enzyme involved in post-transcriptional epigenetic regulation through adenosine-to-inosine (A-to-I) RNA editing.
Xuedi Zhang +8 more
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Systematic analysis of A-to-I RNA editing upon release of ADAR from the nucleolus [PDF]
RNA BiologyAdenosine-to-inosine (A-to-I) RNA editing, catalysed by two ADAR isoforms (p110 and p150) and ADARB1, is a critical regulatory step in gene expression.
Ruben Lattuca +3 more
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An engineered U7 small nuclear RNA scaffold greatly increases ADAR-mediated programmable RNA base editing [PDF]
Nature CommunicationsCustom RNA base editing exploiting the human Adenosine Deaminase Acting on RNA (ADAR) enzyme may enable therapeutic gene editing without DNA damage or use of foreign proteins.
Susan M. Byrne +10 more
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Definitions, 2020 The ADAR1 protein is involved in the control of the innate immune response, which is the immune system's early response to foreign invaders (pathogens).
National Cancer Institute
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ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression
Cell Reports, 2013 Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine, which is then recognized as guanosine. To study the role of ADAR proteins in RNA editing and gene regulation, we sequenced and compared the DNA and RNA of human B cells.
Isabel X. Wang +5 more
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