Results 91 to 100 of about 15,493 (211)

Amblyomma cajennense Sensu Stricto (Fabricius, 1787) and Amblyomma sculptum (Berlese, 1888) Tick Saliva Elicit Immune‐Modulatory Activity in Isolated Murine Macrophages With an Insight Into Proteomic Analysis

Parasite Immunology, Volume 48, Issue 3, March 2026.
ABSTRACT Tick saliva is known to cause immunosuppression and help pathogen transmission. Amblyomma sculptum is a public health concern as a vector of Rickettsia rickettsii. Another close‐related species is Amblyomma cajennense sensu stricto (s.s.). The impact of saliva from these species on murine macrophages remains unclear.
André de Abreu Rangel Aguirre, Valdison Pereira dos Reis, Sulamita da Silva Setúbal, Angélica Lorena Pereira Mendes Carioca, Ketlei Monteiro Tavares, Geisa Paulino Caprini Evaristo, Joseph Albert Medeiros Evaristo, Fábio César Sousa Nogueira, Jansen Fernandes Medeiros, Juliana Pavan Zuliani   +9 more
wiley   +1 more source

Circular RNA circBbs9 promotes PM2.5-induced lung inflammation in mice via NLRP3 inflammasome activation

Environment International, 2020
Fine particulate matter (PM2.5) is one of the most important components of environmental pollutants, and is associated with pulmonary injury. However, the biological mechanisms of pulmonary damage caused by PM2.5 are poorly defined, especially the ...
Meizhen Li, Qiuhan Hua, Yueting Shao, Huixian Zeng, Yufei Liu, Qinqin Diao, Han Zhang, Miaoyun Qiu, Jialu Zhu, Xun Li, Yihui Ling, Rong Zhang, Yiguo Jiang   +12 more
doaj   +1 more source

Role of non-coding RNAs in the transgenerational epigenetic transmission of the effects of reprotoxicants [PDF]

, 2016
13 p.-1 fig.Non-coding RNAs (ncRNAs) are regulatory elements of gene expression and chromatin structure. Both long and small ncRNAs can also act as inductors and targets of epigenetic programs.
Del Mazo, Jesús, Larriba, E.
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 2, Page 409-427, February 2026.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Seven novel mutations of theADAR gene in Chinese families and sporadic patients with dyschromatosis symmetrica hereditaria (DSH) [PDF]

Human Mutation, 2004
Dyschromatosis symmetrica hereditaria (DSH) is an autosomal dominant pigmentary genodermatosis characterized by hyperpigmented and hypopigmented macules of on the extremities and caused by the mutations in the ADAR gene(also called DSRAD) encoding for RNA-specific adenosine deaminase.
Xue-Jun, Zhang, Ping-Ping, He, Ming, Li, Chun-Di, He, Kai-Lin, Yan, Yong, Cui, Sen, Yang, Kai-Yue, Zhang, Min, Gao, Jian-Jun, Chen, Cheng-Rang, Li, Lin, Jin, Hong-Duo, Chen, Shi-Jie, Xu, Wei, Huang   +14 more
openaire   +2 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, Volume 16, Issue 2, Page 299-313, February 2026.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Pan-cancer analysis of ADAR1 with its prognostic relevance in low-grade glioma

Immunobiology
ADAR1, known as the primary enzyme for adenosine-to-inosine RNA editing, has recently been implicated in cancer development through both RNA editing-dependent and −independent pathways.
Qin Yang, Xin Li
doaj   +1 more source

Host Immune Response Driving SARS-CoV-2 Evolution

Viruses, 2020
The transmission and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of paramount importance in controlling and combating the coronavirus disease 2019 (COVID-19) pandemic.
Rui Wang, Yuta Hozumi, Yong-Hui Zheng, Changchuan Yin, Guo-Wei Wei   +4 more
doaj   +1 more source

Endonuclease V: From Transcriptome Regulator to Chemical Biology Tool

ChemistryEurope, Volume 4, Issue 2, February 2026.
Post‐transcriptional modifications play a pivotal role in regulating the health and physiology of human cells, and adenosine‐to‐inosine (A‐to‐I) editing is one of the most abundant of these modifications. Inosine is read as guanosine by the cellular machinery, and this change impacts both the regulation and genetic code of RNA, in turn effectively ...
Prasanth Thota, Tyson D. Todd, Devanshi Purohit, Weina Cheng, Aastha, Jennifer M. Heemstra   +5 more
wiley   +1 more source

An engineered U7 small nuclear RNA scaffold greatly increases ADAR-mediated programmable RNA base editing

Nature Communications
Custom RNA base editing exploiting the human Adenosine Deaminase Acting on RNA (ADAR) enzyme may enable therapeutic gene editing without DNA damage or use of foreign proteins.
Susan M. Byrne, Stephen M. Burleigh, Robert Fragoza, Yue Jiang, Yiannis Savva, Ricky Pabon, Evan Kania, Joseph Rainaldi, Andrew Portell, Prashant Mali, Adrian W. Briggs   +10 more
doaj   +1 more source