Results 111 to 120 of about 6,398,385 (224)

Narrowing down the candidates of beneficial A-to-I RNA editing by comparing the recoding sites with uneditable counterparts

Nucleus
Adar-mediated adenosine-to-inosine (A-to-I) RNA editing mainly occurs in nucleus and diversifies the transcriptome in a flexible manner. It has been a challenging task to identify beneficial editing sites from the sea of total editing events.
Tianyou Zhao, Ling Ma, Shiwen Xu, Wanzhi Cai, Hu Li, Yuange Duan   +5 more
doaj   +1 more source

Epigenetics of Homocystinuria, Hydrogen Sulfide, and Circadian Clock Ablation in Cardiovascular–Renal Disease

Current Issues in Molecular Biology
Morning-time heart attacks are associated with an ablation in the sleep-time dip in blood pressure, the mechanism of which is unknown. The epigenetic changes are the hallmark of sleep and circadian clock disruption and homocystinuria (HHcy).
Suresh C. Tyagi
doaj   +1 more source

Natural Language Query in the Biochemistry and Molecular Biology Domains Based on Cognition Search™ [PDF]

, 2008
Motivation: With the tremendous growth in scientific literature, it is necessary to improve upon the standard pattern matching style of the available search engines. Semantic NLP may be the solution to this problem.
Elizabeth J. Goldsmith, Kathleen Dahlgren, Radha Akella, Saurabh Mendiratta   +3 more
core   +2 more sources

A pipeline for identifying guide RNA sequences that promote RNA editing of nonsense mutations that cause inherited retinal diseases

Molecular Therapy: Nucleic Acids
Adenosine deaminases acting on RNA (ADARs) are endogenous enzymes catalyzing the deamination of adenosines to inosines, which are then read as guanosines during translation. This ability to recode makes ADAR an attractive therapeutic tool to edit genetic
Nina Schneider, Ricky Steinberg, Amit Ben-David, Johanna Valensi, Galit David-Kadoch, Zohar Rosenwasser, Eyal Banin, Erez Y. Levanon, Dror Sharon, Shay Ben-Aroya   +9 more
doaj   +1 more source

Genetic Determinants of RNA Editing Levels of ADAR Targets in Drosophila melanogaster

G3: Genes, Genomes, Genetics, 2016
RNA editing usually affects only a fraction of expressed transcripts and there is a vast amount of variation in editing levels of ADAR (adenosine deaminase, RNA-specific) targets.
Yerbol Z. Kurmangaliyev, Sammi Ali, Sergey V. Nuzhdin   +2 more
doaj   +1 more source

Dysregulated RNA editing of EIF2AK2 in polycystic ovary syndrome: clinical relevance and functional implications

BMC Medicine
Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive ages. Our previous study has implicated a possible link between RNA editing and PCOS, yet the actual role of RNA editing, its association with ...
Fan-Sheng Kong, Junjie Feng, Jin-Ping Yao, Yinghua Lu, Tao Guo, Meng Sun, Chun-Yan Ren, Yun-Yun Jin, Yaping Ma, Jian-Huan Chen   +9 more
doaj   +1 more source

Useful ‘junk': Alu RNAs in the human transcriptome [PDF]

, 2018
.: Alu elements are the most abundant repetitive elements in the human genome; they have amplified by retrotransposition to reach the present number of more than one million copies.
Häsler, J., Samuelsson, T., Strub, K.
core  

An Overview of ADAR Inhibitors: Mechanisms, Applications, and Future Directions

Serican Journal of Medicine
Adenosine deaminases acting on RNA (ADARs) are enzymes responsible for converting adenosine to inosine in double-stranded RNA through a process known as A-to-I editing.
Taufeeque Ali, Qi Cao
semanticscholar   +1 more source

SAGE: Sequential Attribute Generator for Analyzing Glioblastomas using Limited Dataset

, 2020
While deep learning approaches have shown remarkable performance in many imaging tasks, most of these methods rely on availability of large quantities of data. Medical image data, however, is scarce and fragmented.
Allen, Jason, Bhanu, Bir, Bhanu, Shiv, Jonnalagedda, Padmaja, Min, Taejin L., Weinberg, Brent   +5 more
core  

The diverse functions of the ADAR enzymes : Editing and editing-independent effects on gene expression

, 2023
The adenosine deaminase acting on RNA (ADAR) family of enzymes consists of three members (ADAR1-3). These enzymes are responsible for the deamination of adenosine into inosine in double-stranded RNA, one of the most common RNA modifications in mammals.
openaire   +1 more source