ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity. [PDF]
Nature Communications, 2016 It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the
Dickman, DK +3 more
core +2 more sources
The conserved protein kinase-A target motif in synapsin of Drosophila is effectively modified by pre-mRNA editing. [PDF]
BMC Neuroscience, 2011 RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Buchner, Erich +5 more
core +4 more sources
Seven novel mutations of theADAR gene in Chinese families and sporadic patients with dyschromatosis symmetrica hereditaria (DSH) [PDF]
Human Mutation, 2004 Dyschromatosis symmetrica hereditaria (DSH) is an autosomal dominant pigmentary genodermatosis characterized by hyperpigmented and hypopigmented macules of on the extremities and caused by the mutations in the ADAR gene(also called DSRAD) encoding for RNA-specific adenosine deaminase.
Lin Jin +15 more
openaire +4 more sources
RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells [PDF]
Molecular MetabolismObjective: A longstanding question in type 1 diabetes (T1D) research pertains to the selective loss of β-cells whilst neighboring islet α-cells remain unharmed.
Shani Peleg +12 more
doaj +2 more sources
A-to-I RNA Editing: Current Knowledge Sources and Computational Approaches with Special Emphasis on Non-Coding RNA Molecules [PDF]
Frontiers in Bioengineering and Biotechnology, 2015 RNA editing is a dynamic mechanism for gene regulation attained through the alteration of the sequence of primary RNA transcripts. A-to-I (Adenosine-to-Inosine) RNA editing, which is catalyzed by members of the Adenosine Deaminase Acting on RNA (ADAR ...
Alfredo Ferro +2 more
core +4 more sources
Emerging clinical applications of ADAR based RNA editing [PDF]
Stem Cells Transl MedRNA editing via adenosine deaminases acting on RNA (ADARs) offers precise and reversible modifications at the RNA level, complementing traditional DNA-targeting therapies.
Joseph Rainaldi +2 more
semanticscholar +2 more sources
Increasing the Editing Efficiency of the MS2-ADAR System for Site-Directed RNA Editing
Applied Sciences, 2023 Site-directed RNA editing (SDRE) technologies have great potential in gene therapy. Our group has developed a strategy to redirect exogenous adenosine deaminases acting on RNA (ADARs) to specific sites by making editable structures using antisense RNA ...
Jiarui Li +4 more
doaj +2 more sources
ADAR1 haploinsufficiency and sustained picornaviral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy [PDF]
mBioSensing of viral double-stranded RNA (dsRNA) by MDA5 triggers abundant but transient interferon-stimulated gene (ISGs) expression. If dsRNA synthesis is made persistent by transgenically expressing a picornaviral RNA-dependent RNA polymerase (RdRp) in ...
Caitlin M. Miller +7 more
doaj +2 more sources
VIRMA promotes NSCLC progression by modifying ADAR m6A and increasing the activity of the TGF-β signaling pathway [PDF]
Scientific ReportsThe N6-methyladenosine (m6A) modification is prevalently found in mRNAs and lncRNAs in various eukaryotic organisms, playing a crucial role in biological processes.
Yuchen Shan +8 more
doaj +2 more sources
Programming ADAR-recruiting hairpin RNA sensor to detect endogenous molecules [PDF]
Nucleic Acids ResRNA editing leveraging ADARs (adenosine deaminases acting on RNA) shows promising potential for in vivo biosensing beyond gene therapy. However, current ADAR sensors sense only a single target of RNA transcripts, thus limiting their use in different ...
Peipei Qin +5 more
semanticscholar +2 more sources