Adar contributes to genome integrity by regulating R-loop homeostasis in Drosophila [PDF]
BMC BiologyBackground Adenosine deaminase acting on RNA (Adar) is a critical enzyme involved in post-transcriptional epigenetic regulation through adenosine-to-inosine (A-to-I) RNA editing.
Xuedi Zhang +8 more
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Identification and validation of PANoptosis-related genes in ankylosing spondylitis [PDF]
BMC Medical GenomicsAnkylosing spondylitis (AS) is a common immune inflammatory disease. PANoptosis, as a novel programmed cell death pathway, its mechanism of action in ankylosing spondylitis remains unclear.
Zhitao Shan +4 more
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Systematic analysis of A-to-I RNA editing upon release of ADAR from the nucleolus [PDF]
RNA BiologyAdenosine-to-inosine (A-to-I) RNA editing, catalysed by two ADAR isoforms (p110 and p150) and ADARB1, is a critical regulatory step in gene expression.
Ruben Lattuca +3 more
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Evaluation of in vitro liver models and non-human primates for predicting ADAR RNA editing efficiency in human liver [PDF]
Scientific ReportsLiver-originated diseases remain a significant global health burden, with limited treatment options available. RNA therapeutics, particularly adenosine deaminase acting on RNA (ADAR)-mediated editing using editing oligonucleotides (EONs) offer a novel ...
Monica Aguila +8 more
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A-to-I RNA editing: current knowledge sources and computational approaches with special emphasis on non-coding RNA molecules [PDF]
Frontiers in Bioengineering and Biotechnology, 2015 RNA editing is a dynamic mechanism for gene regulation attained through the alteration of the sequence of primary RNA transcripts. A-to-I (Adenosine-to-Inosine) RNA editing, which is catalyzed by members of the Adenosine Deaminase Acting on RNA (ADAR ...
Giovanni eNigita +2 more
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Two codes of RNA editing by deamination in human diseases [PDF]
Experimental and Molecular MedicineRNA editing is a post-transcriptional modification that expands transcriptomic and proteomic diversity. Advances in high-throughput sequencing across a broad range of biological and pathological contexts have enabled systematic identification of editing ...
Dong Jun Min +3 more
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Caenorhabditis elegans mRNAs that encode a protein similar to ADARs derive from an operon containing six genes [PDF]
Nucleic Acids Research, 1999 The Caenorhabditis elegans T20H4.4 open reading frame (GenBank accession no. U00037) predicted by Genefinder encodes a 367 amino acid protein that is 32-35% identical to the C-terminal domain of adenosine deaminases that act on RNA. We show that T20H4.4 cDNAs (GenBank accession no.
R Hough, Arunth T. Lingam, Brenda Bass
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An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer [PDF]
Nucleic Acids Research, 2017 Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by Adenosine DeAminases acting on double-stranded RNA(dsRNA) (ADAR), occurs predominantly in the 3' untranslated regions (3'UTRs) of spliced mRNA. Here we uncover an unanticipated link between ADARs (ADAR1 and ADAR2) and the expression of target genes undergoing extensive 3'UTR editing. Using METTL7A
Lihua Qi +14 more
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RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells [PDF]
Molecular MetabolismObjective: A longstanding question in type 1 diabetes (T1D) research pertains to the selective loss of β-cells whilst neighboring islet α-cells remain unharmed.
Shani Peleg +12 more
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ADBP-1 Regulates an ADAR RNA-Editing Enzyme to Antagonize RNA-Interference-Mediated Gene Silencing in Caenorhabditis elegans [PDF]
Genetics, 2008 Abstract Small interfering RNAs (siRNAs) and microRNAs (miRNAs) mediate gene silencing through evolutionarily conserved pathways. In Caenorhabditis elegans, the siRNA/miRNA pathways are also known to affect transgene expression. To identify genes that regulate the efficiencies of the siRNA/miRNA pathways, we used the expression level of ...
Hiromitsu Ohta +3 more
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