Results 31 to 40 of about 6,398,385 (224)

The role of dsRNA A-to-I editing catalyzed by ADAR family enzymes in the pathogeneses

RNA Biology
The process of adenosine deaminase (ADAR)-catalyzed double-stranded RNA (dsRNA) Adenosine-to-Inosine (A-to-I) editing is essential for the correction of pathogenic mutagenesis, as well as the regulation of gene expression and protein function in mammals.
Wanqing Liu, Yufan Wu, Tong Zhang, Xiaobo Sun, Dean Guo, Zizhao Yang   +5 more
doaj   +2 more sources

Systematic analysis of A-to-I RNA editing upon release of ADAR from the nucleolus

RNA Biology
Adenosine-to-inosine (A-to-I) RNA editing, catalysed by two ADAR isoforms (p110 and p150) and ADARB1, is a critical regulatory step in gene expression.
Ruben Lattuca, Rümeyza Bascetin, Vincent Detours, Denis L. J. Lafontaine   +3 more
doaj   +2 more sources

Adaptive evolution of A-to-I auto-editing site in Adar of eusocial insects

BMC Genomics
Background Adenosine-to-inosine (A-to-I) RNA editing is a co-/post-transcriptional modification introducing A-to-G variations in RNAs. There is extensive discussion on whether the flexibility of RNA editing exerts a proteomic diversification role, or it ...
Caiqing Zheng, Jiyao Liu, Yuange Duan
doaj   +2 more sources

Identification of the pathogenic variants in three Chinese families with dyschromatosis symmetrica hereditaria [PDF]

Jichu yixue yu linchuang, 2023
Objective To analyze the clinical features and to identify the pathogenic variants in three Chinese families with dyschromatosis symmetrica hereditaria (DSH).
YANG Xueting, GUO Kexin, SUN Yang, WANG Rongrong, MA Donglai, ZHANG Xue
doaj   +1 more source

ADAR expression and copy number variation in patients with advanced gastric cancer

BMC Gastroenterology, 2020
Background Gastric cancer (GC) is a world health problem and it is the third leading cause of cancer deaths worldwide. The current practice for prognosis assessment in GC is based on radiological and pathological criteria and they may not result in an ...
Javad Behroozi, Shirin Shahbazi, Mohammad Reza Bakhtiarizadeh, Habibollah Mahmoodzadeh   +3 more
doaj   +1 more source

Programmable RNA editing with endogenous ADAR enzymes – a feasible option for the treatment of inherited retinal disease?

Frontiers in Molecular Neuroscience, 2023
RNA editing holds great promise for the therapeutic correction of pathogenic, single nucleotide variants (SNV) in the human transcriptome since it does not risk creating permanent off-targets edits in the genome and has the potential for innovative ...
Julia-Sophia Bellingrath, Michelle E. McClements, M. Dominik Fischer, M. Dominik Fischer, Robert E. MacLaren, Robert E. MacLaren   +5 more
doaj   +1 more source

Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish. [PDF]

PLoS Genetics, 2015
Fragile X syndrome (FXS) is the most frequent inherited form of mental retardation. The cause for this X-linked disorder is the silencing of the fragile X mental retardation 1 (fmr1) gene and the absence of the fragile X mental retardation protein (Fmrp).
Adi Shamay-Ramot, Khen Khermesh, Hagit T Porath, Michal Barak, Yishay Pinto, Chaim Wachtel, Alona Zilberberg, Tali Lerer-Goldshtein, Sol Efroni, Erez Y Levanon, Lior Appelbaum   +10 more
doaj   +1 more source

Comparison of CRISPR-Cas13b RNA base editing approaches for USH2A-associated inherited retinal degeneration [PDF]

Communications Biology
CRISPR-Cas13 systems have therapeutic promise for the precise correction of point mutations in RNA. Using adenosine deaminase acting on RNA (ADAR) effectors, A-I base conversions can be targeted using guide RNAs (gRNAs).
Lewis E. Fry, Lauren Major, Ahmed Salman, Lucy A. McDermott, Jun Yang, Andrew J. King, Michelle E. McClements, Robert E. MacLaren   +7 more
doaj   +2 more sources

Elevated ADAR expression is significantly linked to shorter overall survival and immune infiltration in patients with lung adenocarcinoma

Mathematical Biosciences and Engineering, 2023
To date, few studies have investigated whether the RNA-editing enzymes adenosine deaminases acting on RNA (ADARs) influence RNA functioning in lung adenocarcinoma (LUAD).
Siqi Hu , Fang Wang, Junjun Yang, Xingxiang Xu   +3 more
doaj   +1 more source

DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. [PDF]

, 2017
Adenosine deaminases that act on RNA (ADARs) carry out adenosine (A) to inosine (I) editing reactions with a known requirement for duplex RNA. Here, we show that ADARs also react with DNA/RNA hybrid duplexes.
Beal, Peter A, Lorenzo, Claire, Zheng, Yuxuan   +2 more
core   +1 more source