Results 51 to 60 of about 15,493 (211)

Activity-regulated RNA editing in select neuronal subfields in hippocampus [PDF]

, 2012
RNA editing by adensosine deaminases is a widespread mechanism to alter genetic information in metazoa. In addition to modifications in non-coding regions, editing contributes to diversification of protein function, in analogy to alternative splicing ...
Ales Balik, Altschul, Andrew C. Penn, Aruscavage, Bass, Birney, Bratt, Brorson, Coleman, Coleman, Daniel, Darty, Dawson, de la Mata, Feldmeyer, Feng, Fisahn, Gahwiler, Gainey, Gallo, Ge, Goodman, Greger, Greger, Greger, Gurevich, Hamada, Hideyama, Hideyama, Higuchi, Higuchi, Hoopengardner, Hundley, Ingo H. Greger, Jepson, Katoh, Kent, Lee, Lein, Li, Liu, Lomeli, Maas, Marcucci, Palladino, Paul, Peng, Peng, Penn, Penn, Penn, Pozo, Rosenthal, Rueter, Ryman, Sanjana, Schoft, Seeburg, Seeburg, Sommer, Sommer, Stefl, Stefl, Tariq, Toth, Traynelis, Turrigiano, Turrigiano, Valente, Venkatesh, Wang, Witter, Xie, Zsofia Nemoda   +73 more
core   +1 more source

Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma. [PDF]

, 2015
Background: ADAR enzymes convert adenosines to inosines within double-stranded RNAs, including microRNA (miRNA) precursors, with important consequences on miRNA retargeting and expression.
Alon, S, Eisenberg, E, Galardi, S, Galeano, F, Gallo, A., Locatelli, F, Polito, V, Presutti, Carlo, Raho, S, Tomaselli, S, Vincenti, S   +10 more
core   +2 more sources

Recurrent encephalopathy with spinal cord involvement: An atypical manifestation of Aicardi–Goutières syndrome

Annals of Indian Academy of Neurology, 2019
Aicardi–Goutières syndrome (AGS) is a rare, genetic inflammatory disease due to mutations in any of the seven genes discovered to date (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1).
Debopam Samanta, Raghu Ramakrishnaiah
doaj   +1 more source

Population and allelic variation of A-to-I RNA editing in human transcriptomes. [PDF]

, 2017
BackgroundA-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines.
Demirdjian, Levon, Guo, Jiguang, Lin, Lan, Park, Eddie, Shen, Shihao, Wu, Ying Nian, Xing, Yi   +6 more
core   +2 more sources

Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish.

PLoS Genetics, 2015
Fragile X syndrome (FXS) is the most frequent inherited form of mental retardation. The cause for this X-linked disorder is the silencing of the fragile X mental retardation 1 (fmr1) gene and the absence of the fragile X mental retardation protein (Fmrp).
Adi Shamay-Ramot, Khen Khermesh, Hagit T Porath, Michal Barak, Yishay Pinto, Chaim Wachtel, Alona Zilberberg, Tali Lerer-Goldshtein, Sol Efroni, Erez Y Levanon, Lior Appelbaum   +10 more
doaj   +1 more source

Genome-wide analysis of consistently RNA edited sites in human blood reveals interactions with mRNA processing genes and suggests correlations with cell types and biological variables

BMC Genomics, 2018
Background A-to-I RNA editing is a co−/post-transcriptional modification catalyzed by ADAR enzymes, that deaminates Adenosines (A) into Inosines (I).
Edoardo Giacopuzzi, Massimo Gennarelli, Chiara Sacco, Alice Filippini, Jessica Mingardi, Chiara Magri, Alessandro Barbon   +6 more
doaj   +1 more source

ADAR2 Protein Is Associated with Overall Survival in GBM Patients and Its Decrease Triggers the Anchorage-Independent Cell Growth Signature

Biomolecules, 2022
Background: Epitranscriptomic mechanisms, such as A-to-I RNA editing mediated by ADAR deaminases, contribute to cancer heterogeneity and patients’ stratification.
Valeriana Cesarini, Domenico Alessandro Silvestris, Federica Galeano, Valentina Tassinari, Maurizio Martini, Franco Locatelli, Angela Gallo   +6 more
doaj   +1 more source

Current epigenetic aspects the clinical kidney researcher should embrace [PDF]

, 2017
Chronic kidney disease (CKD), affecting 10-12% of the world's adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature vascular disease and death.
Ekström, Tomas J., Nordfors, Louise, Shiels, Paul G., Stenvinkel, Peter, Van Craenenbroeck, Amaryllis H., Witasp, Anna   +5 more
core   +1 more source

Proteotranscriptomics of ocular adnexal B-cell lymphoma reveals an oncogenic role of alternative splicing and identifies a diagnostic marker

Journal of Experimental & Clinical Cancer Research, 2022
Background Ocular adnexal B-cell lymphoma (OABL) is a rare subtype of non-Hodgkin lymphoma. The molecular characteristics of OABL remain poorly understood.
Jiahao Shi, Tianyu Zhu, Huimin Lin, Zhen Liu, Min Zhou, Ziyao Yu, Xiaowen Zhou, Xin Song, Yefei Wang, Renbing Jia, Xianqun Fan, Yixiong Zhou   +11 more
doaj   +1 more source

Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR-B R/G site [PDF]

, 2002
RNA editing by members of the ADAR (adenosine deaminase that acts on RNA) enzyme family involves hydrolytic deamination of adenosine to inosine within the context of a double-stranded pre-mRNA substrate.
Collins, Cynthia H., Jaikaran, Dominic C. J., MacMillan, Andrew M.   +2 more
core   +1 more source