Results 51 to 60 of about 6,398,385 (224)
Molecular Genetics & Genomic Medicine, 2019 Background Dyschromatosis symmetrica hereditaria (DSH;OMIM: #127400) is a rare autosomal dominant skin disease of hyperpigmented and hypopigmented macules on the dorsal aspects of the feet and hands.
Peng Wang +4 more
doaj +1 more source
Develop a Compact RNA Base Editor by Fusing ADAR with Engineered EcCas6e
Advancement of science, 2023 Catalytically inactive CRISPR‐Cas13 (dCas13)‐based base editors can achieve the conversion of adenine‐to‐inosine (A‐to‐I) or cytidine‐to‐uridine (C‐to‐U) at the RNA level, however, the large size of dCas13 protein limits its in vivo applications. Here, a
Xing Wang +12 more
semanticscholar +1 more source
RNA editing signature during myeloid leukemia cell differentiation [PDF]
, 2017 Adenosine deaminases acting on RNA (ADARs) are key proteins for hematopoietic stem cell self-renewal and for survival of differentiating progenitor cells. However, their specific role in myeloid cell maturation has been poorly investigated.
A Athanasiadis +48 more
core +2 more sources
Drug Metabolism And Disposition, 2023 Two RNA-editing proteins, the adenosine deaminase acting on RNA, ADAR, and ADARB1, broadly regulate gene expression in editing-dependent and editing-independent manners.
J. M. Collins, Danxin Wang
semanticscholar +1 more source
Graph Few-shot Learning via Knowledge Transfer
, 2020 Towards the challenging problem of semi-supervised node classification, there have been extensive studies. As a frontier, Graph Neural Networks (GNNs) have aroused great interest recently, which update the representation of each node by aggregating ...
Chawla, Nitesh V. +7 more
core +1 more source
New insights into the biological role of mammalian ADARs; the RNA editing proteins [PDF]
, 2015 The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Arieti, Fabiana +4 more
core +2 more sources
Biomolecules, 2022 Background: Epitranscriptomic mechanisms, such as A-to-I RNA editing mediated by ADAR deaminases, contribute to cancer heterogeneity and patients’ stratification.
Valeriana Cesarini +6 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Viral RNA may be edited by enzymes of the ADAR family that deaminate adenosine residues with ensuing A→G mutations. We found multiple A→G mutations in minor viral populations of the SARS-CoV-2 genome.
Johan Ringlander +10 more
semanticscholar +1 more source
Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. [PDF]
, 2016 Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Beal, Peter A, Wang, Yuru
core +1 more source
Annals of Indian Academy of Neurology, 2019 Aicardi–Goutières syndrome (AGS) is a rare, genetic inflammatory disease due to mutations in any of the seven genes discovered to date (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1).
Debopam Samanta, Raghu Ramakrishnaiah
doaj +1 more source