Results 61 to 70 of about 6,398,385 (224)

Adar-mediated A-to-I editing is required for embryonic patterning and innate immune response regulation in zebrafish

Nature Communications, 2022
Adenosine deaminases (ADARs) catalyze the deamination of adenosine to inosine, also known as A-to-I editing, in RNA. Although A-to-I editing occurs widely across animals and is well studied, new biological roles are still being discovered. Here, we study
K. Nieścierowicz, Leszek P. Pryszcz, Cristina Navarrete, Eugeniusz Tralle, Agata A. Sulej, Karim Abu Nahia, Marta elzbieta Kasprzyk, K. Misztal, Abhishek Pateria, Adrianna Pakuła, M. Bochtler, C. Winata   +11 more
semanticscholar   +1 more source

Activity-regulated RNA editing in select neuronal subfields in hippocampus [PDF]

, 2012
RNA editing by adensosine deaminases is a widespread mechanism to alter genetic information in metazoa. In addition to modifications in non-coding regions, editing contributes to diversification of protein function, in analogy to alternative splicing ...
Ales Balik, Altschul, Andrew C. Penn, Aruscavage, Bass, Birney, Bratt, Brorson, Coleman, Coleman, Daniel, Darty, Dawson, de la Mata, Feldmeyer, Feng, Fisahn, Gahwiler, Gainey, Gallo, Ge, Goodman, Greger, Greger, Greger, Gurevich, Hamada, Hideyama, Hideyama, Higuchi, Higuchi, Hoopengardner, Hundley, Ingo H. Greger, Jepson, Katoh, Kent, Lee, Lein, Li, Liu, Lomeli, Maas, Marcucci, Palladino, Paul, Peng, Peng, Penn, Penn, Penn, Pozo, Rosenthal, Rueter, Ryman, Sanjana, Schoft, Seeburg, Seeburg, Sommer, Sommer, Stefl, Stefl, Tariq, Toth, Traynelis, Turrigiano, Turrigiano, Valente, Venkatesh, Wang, Witter, Xie, Zsofia Nemoda   +73 more
core   +1 more source

Proteotranscriptomics of ocular adnexal B-cell lymphoma reveals an oncogenic role of alternative splicing and identifies a diagnostic marker

Journal of Experimental & Clinical Cancer Research, 2022
Background Ocular adnexal B-cell lymphoma (OABL) is a rare subtype of non-Hodgkin lymphoma. The molecular characteristics of OABL remain poorly understood.
Jiahao Shi, Tianyu Zhu, Huimin Lin, Zhen Liu, Min Zhou, Ziyao Yu, Xiaowen Zhou, Xin Song, Yefei Wang, Renbing Jia, Xianqun Fan, Yixiong Zhou   +11 more
doaj   +1 more source

ADAR regulates APOL1 via A-to-I RNA editing by inhibition of MDA5 activation in a paradoxical biological circuit

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance APOL1-associated kidney disease occurs in some but not all individuals carrying two copies of APOL1 genetic risk variants. The factors leading to kidney disease are incompletely understood. Viral illnesses or other environmental triggers are
Cristian V Riella, M. McNulty, Guilherme T. Ribas, Calum F Tattersfield, Chandra Perez-Gill, F. Eichinger, Jessica M. Kelly, J. Chun, Balajikarthick Subramanian, Dieval Guizelini, S. Alper, M. Pollak, M. Sampson, D. Friedman   +13 more
semanticscholar   +1 more source

An extra double-stranded RNA binding domain confers high activity to a squid RNA editing enzyme [PDF]

, 2009
RNA editing by adenosine deamination is particularly prevalent in the squid nervous system. We hypothesized that the squid editing enzyme might contain structural differences that help explain this phenomenon. As a first step, a squid adenosine deaminase
O'Connell, Mary A, Palavicini, Juan Pablo, Rosenthal, Joshua J C   +2 more
core   +2 more sources

Genome-wide analysis of consistently RNA edited sites in human blood reveals interactions with mRNA processing genes and suggests correlations with cell types and biological variables

BMC Genomics, 2018
Background A-to-I RNA editing is a co−/post-transcriptional modification catalyzed by ADAR enzymes, that deaminates Adenosines (A) into Inosines (I).
Edoardo Giacopuzzi, Massimo Gennarelli, Chiara Sacco, Alice Filippini, Jessica Mingardi, Chiara Magri, Alessandro Barbon   +6 more
doaj   +1 more source

Gene-Based Therapeutics for Inherited Retinal Diseases

Frontiers in Genetics, 2022
Inherited retinal diseases (IRDs) are a heterogenous group of orphan eye diseases that typically result from monogenic mutations and are considered attractive targets for gene-based therapeutics.
Beau J. Fenner, Beau J. Fenner, Beau J. Fenner, Tien-En Tan, Tien-En Tan, Tien-En Tan, Amutha Veluchamy Barathi, Sai Bo Bo Tun, Sia Wey Yeo, Andrew S. H. Tsai, Andrew S. H. Tsai, Andrew S. H. Tsai, Shu Yen Lee, Shu Yen Lee, Shu Yen Lee, Chui Ming Gemmy Cheung, Chui Ming Gemmy Cheung, Chui Ming Gemmy Cheung, Choi Mun Chan, Choi Mun Chan, Choi Mun Chan, Jodhbir S. Mehta, Jodhbir S. Mehta, Jodhbir S. Mehta, Jodhbir S. Mehta, Jodhbir S. Mehta, Kelvin Y. C. Teo, Kelvin Y. C. Teo, Kelvin Y. C. Teo   +28 more
doaj   +1 more source

A-to-I RNA editing in the earliest-diverging Eumetazoan phyla [PDF]

, 2017
© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology and Evolution 34 (2017): 1890-1901, doi:10.1093/molbev/msx125.The highly conserved ...
Alon, Shahar, Eisenberg, Eli, Kaniewska, Paulina, Levanon, Erez, Levy, Oren, Porath, Hagit T., Rosenthal, Joshua J. C., Schaffer, Amos A.   +7 more
core   +1 more source

RNA editing of the 5-HT2C receptor in the central nucleus of the amygdala is involved in resilience behavior

Translational Psychiatry, 2021
Post-traumatic-stress-disorder (PTSD) is a stress-related condition that may develop after exposure to a severe trauma-event. One of the core brain areas that is considered to be a key regulatory region of PTSD is the amygdala.
Gal Warhaftig, Chaya Mushka Sokolik, Khen Khermesh, Yehuda Lichtenstein, Michal Barak, Tzofnat Bareli, Erez Y. Levanon, Gal Yadid   +7 more
doaj   +1 more source

Population and allelic variation of A-to-I RNA editing in human transcriptomes. [PDF]

, 2017
BackgroundA-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines.
Demirdjian, Levon, Guo, Jiguang, Lin, Lan, Park, Eddie, Shen, Shihao, Wu, Ying Nian, Xing, Yi   +6 more
core   +2 more sources