Results 71 to 80 of about 6,398,385 (224)

Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma. [PDF]

, 2015
Mice in which lung epithelial cells can be induced to express an oncogenic Kras(G12D) develop lung adenocarcinomas in a manner analogous to humans. A myriad of genetic changes accompany lung adenocarcinomas, many of which are poorly understood.
Caswell, DR, Chu, K, Chuang, C-H, Kay, MA, Kim, HK, Roy-Chaudhuri, B, Sayles, LC, Sweet-Cordero, EA, Valdmanis, PN, Winslow, MM, Zhang, Y, Zheng, Y   +11 more
core   +2 more sources

Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing [PDF]

, 2012
Adenosine-to-Inosine (A-to-I) RNA editing is a post-transcriptional mechanism, evolved to diversify the transcriptome in metazoa. In addition to wide-spread editing in non-coding regions protein recoding by RNA editing allows for fine tuning of protein ...
Ales Balik, Altschul, Andrew C. Penn, Arzumanov, Arzumanov, Balik, Bass, Birney, Brusa, Carver, Daniel, Darty, Dominski, Egebjerg, Eisen, Enstero, Feldmeyer, Gallo, Ge, Greger, Hamada, Heasman, Higuchi, Higuchi, Hogg, Ingo H. Greger, Jepson, Jubin, Katoh, Kent, Kwak, Laurencikiene, Maas, Moulton, Peng, Reenan, Rice, Rosenthal, Rueter, Ryman, Schoft, Sommer, Stephens, Summerton, Summerton, Summerton, Tariq, Traynelis, Valente, Venkatesh, Yamashita, Yang   +51 more
core   +1 more source

ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface

Advanced Science, EarlyView.
This study reveals that ADAR1, an RNA‐editing enzyme, fine‐tunes immune responses in the placenta by preventing the accumulation of immunogenic double‐stranded RNAs (dsRNAs) from interferon‐stimulated genes. The loss of ADAR1 in the placenta leads to excessive interferon signaling restricted to the junctional zone, disrupting placental development and ...
Xiaogang Chen, Xiangchao Xu, Jiahao Chen, Huiru Zhang, Wanshan Zheng, Wenzhe Yu, Xiaoqian Hu, Bin Cao   +7 more
wiley   +1 more source

Current epigenetic aspects the clinical kidney researcher should embrace [PDF]

, 2017
Chronic kidney disease (CKD), affecting 10-12% of the world's adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature vascular disease and death.
Ekström, Tomas J., Nordfors, Louise, Shiels, Paul G., Stenvinkel, Peter, Van Craenenbroeck, Amaryllis H., Witasp, Anna   +5 more
core   +1 more source

diPaRIS: Dynamic and Interpretable Protein‐RNA Interactions Prediction With U‐Shaped Network and Novel Structure Encoding

Advanced Science, EarlyView.
This study presents diPaRIS, a deep learning method designed to predict dynamic protein‐ RNA interactions with enhanced accuracy. By integrating RNA structures in vivo through a novel encoding scheme for nucleotide correlations, diPaRIS improves the interpretability of binding motifs and outperforms current state‐of‐the‐art methods across multiple ...
Lishen Zhang, Chengqian Lu, Xiaoqing Peng, Fei Guo, Hongdong Li, Jianxin Wang   +5 more
wiley   +1 more source

RNA editing of microRNA prevents RNA-induced silencing complex recognition of target mRNA [PDF]

Open Biology, 2015
MicroRNAs (miRNAs) integrate with Argonaut (Ago) to create the RNA-induced silencing complex, and regulate gene expression by silencing target mRNAs. RNA editing of miRNA may affect miRNA processing, assembly of the Ago complex and target mRNA binding ...
Yalei Cui, Tianzhi Huang, Xiaobo Zhang   +2 more
doaj   +1 more source

Conserved microRNA editing in mammalian evolution, development and disease. [PDF]

, 2014
BACKGROUND: Mammalian microRNAs (miRNAs) are sometimes subject to adenosine-to-inosine RNA editing, which can lead to dramatic changes in miRNA target specificity or expression levels.
Halbert, J., Kaessmann, H., Liechti, A., Valloton, D., Warnefors, M.   +4 more
core   +3 more sources

Alu Overexpression Leads to an Increased Double‐stranded RNA Signature in Dermatomyositis

Arthritis &Rheumatology, Accepted Article.
Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the non‐coding genome in disease pathogenesis.
Rayan Najjar, Andrew Mammen, Tomas Mustelin   +2 more
wiley   +1 more source

Link Prediction using Top-$k$ Shortest Distances

, 2017
In this paper, we apply an efficient top-$k$ shortest distance routing algorithm to the link prediction problem and test its efficacy. We compare the results with other base line and state-of-the-art methods as well as with the shortest path. Our results
Lebedev, Andrei, Lee, JooYoung, Mazzara, Manuel, Rivera, Victor   +3 more
core   +1 more source

Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR-B R/G site [PDF]

, 2002
RNA editing by members of the ADAR (adenosine deaminase that acts on RNA) enzyme family involves hydrolytic deamination of adenosine to inosine within the context of a double-stranded pre-mRNA substrate.
Collins, Cynthia H., Jaikaran, Dominic C. J., MacMillan, Andrew M.   +2 more
core   +1 more source