Results 1 to 10 of about 116,785 (352)
Frontiers in Microbiology, 2023 Adeno-associated viruses (AAV) are among the foremost vectors for in vivo gene therapy. A number of monoclonal antibodies against several serotypes of AAV have previously been prepared.
Edward E. Large, Michael S. Chapman
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Protein Carrier Adeno-Associated Virus. [PDF]
ACS NanoAdeno-associated virus (AAV) has emerged as a leading platform for gene therapy, enabling the delivery of therapeutic DNA to target cells. However, the potential of AAV to deliver protein payloads has been unexplored. In this study, we engineered a protein carrier AAV (pcAAV) to package and deliver proteins by inserting binding domains on the interior ...
Hoffmann MD +4 more
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Retinal Penetrating Adeno-Associated Virus. [PDF]
Invest Ophthalmol Vis SciThe most common method of delivery of genes to the outer retina uses recombinant adeno-associated virus (AAV) injected into the subretinal space using a surgical procedure. In contrast, most drugs are delivered to the retina using an intravitreal approach in an office setting. The objective of the current study was to develop AAV vectors that can reach
Kumar B +3 more
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An adeno-associated virus gene therapy strategy for anti-obesity treatment by nanocarrier-based delivery systems [PDF]
Journal of NanobiotechnologyGut microbiota is increasingly recognized for its profound influence on host metabolism. However, the mechanisms underlying the distinct metabolic phenotype observed in germ-free (GF) mice are not fully understood.
Li Li +11 more
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Frontiers in Immunology, 2021 PurposeTo develop a novel method to quantify the amount of fibrosis in the salivary gland and to investigate the relationship between fibrosis and specific symptoms associated with Sjögren’s syndrome (SS) using this method.Materials and MethodsParaffin ...
Hongen Yin +6 more
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Advancing Luciferase-Based Antibody Immunoassays to Next-Generation Mix and Read Testing
Biosensors, 2023 Antibody measurements play a central role in the diagnosis of many autoimmune and infectious diseases. One antibody detection technology, Luciferase Immunoprecipitation Systems (LIPS), utilizes genetically encoded recombinant luciferase antigen fusion ...
Peter D. Burbelo +2 more
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Correction of LAMP3-associated salivary gland hypofunction by aquaporin gene therapy
Scientific Reports, 2022 Sjögren’s disease (SjD) is a chronic autoimmune sialadenitis resulting in salivary gland hypofunction with dry mouth symptom. Previous studies showed that lysosome-associated membrane protein 3 (LAMP3) overexpression is involved in the development of ...
Hiroyuki Nakamura +7 more
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BMJ Open, 2022 Objectives To examine the positive rate of sarcopenia using the ‘Yubi-wakka’ (finger-ring) test and associated risk factors among adults aged 65 years and older.Design Cross-sectional study.Setting We used the Yubi-wakka test, which has been developed ...
Hiroyuki Nakamura +5 more
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LAMP3 transfer via extracellular particles induces apoptosis in Sjögren’s disease
Scientific Reports, 2023 Sjögren’s disease (SjD) is an autoimmune disease that affects exocrine tissues and is characterized by increased apoptosis in salivary and lacrimal glands.
Tsutomu Tanaka +7 more
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Molecular Therapy: Methods & Clinical Development, 2022 Gene therapy using neurotropic adeno-associated virus vectors represents an emerging solution for genetic disorders affecting the central nervous system. The first approved central nervous system-targeting adeno-associated virus gene therapy, Zolgensma®,
Makoto Horiuchi +10 more
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