Aggressive Right-Sided Colon Cancer in a Young Adult: Triple-Whammy Mutations (POLE, KRAS, BRCA1/2) Highlight Emerging Genetic Associations. [PDF]
ACG Case Rep JPatel R +4 more
europepmc +1 more source
Rapamycin rescues APC-mutated colon organoid differentiation. [PDF]
Cancer Gene TherHabib A, Mamistvalov R, Ben-Yosef D.
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Genomic alterations in the WNT/β-catenin pathway and resistance of colorectal cancer cells to pathway-targeting therapies. [PDF]
Explor Target Antitumor TherVoutsadakis IA.
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A review of APC somatic mosaicism and specific APC variants - I1307K and promotor variants. [PDF]
Fam CancerShur S +4 more
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Dietary polyphenols as modulators of cell signaling and inflammation in colorectal carcinogenesis. [PDF]
Front NutrTan BL, Zulkifli F, Norhaizan ME.
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Proteomics-based prognostic signature in colon adenocarcinoma patients with familial adenomatous polyposis. [PDF]
Transl Cancer ResLi SQ, Jiang W, Zhu YC.
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A role for the Adenomatous Polyposis Coli protein in chromosome segregation
Nature Cell Biology, 2001Mutations in the Adenomatous Polyposis Coli (APC) gene are responsible for familial colon cancer and also occur in the early stages of sporadic colon cancer. APC functions in the Wnt signalling pathway to regulate the degradation of beta-catenin (reviewed in refs 1-3).
K. Kaplan +5 more
semanticscholar +4 more sources
The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium.
Annual Review of Cell and Developmental Biology, 2004▪ Abstract The Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon cancers, and the APC protein has emerged as a multifunctional protein that is not only involved in the Wnt-regulated degradation of β-catenin, but also regulates cytoskeletal proteins and thus plays a role in cell migration, cell adhesion, and mitosis.
I. Näthke
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The adenomatous polyposis coli protein: in the limelight out at the edge.
Trends in Cell Biology, 2001Truncation mutations in the adenomatous polyposis coli protein (APC) are responsible for familial and sporadic colonic tumours. APC is best known for its role in regulating beta-catenin, an important mediator of cell adhesion and a transcriptional activator. However, recent studies indicate that APC has additional roles in cytoskeletal regulation.
D. Dikovskaya +3 more
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