Results 61 to 70 of about 23,918 (237)

APCI1307K Mutations and Forkhead Box Gene (FOXO1A): Another Piece of an Interesting Correlation

The International Journal of Biological Markers, 2012
Purpose Germline nonsense and frameshift mutations in the adenomatous polyposis coli (APC) gene are found in approximately 90% of individuals affected by familial adenomatous polyposis (FAP) and a genotype-phenotype relationship has been observed ...
Marco Agostini, Chiara Bedin, Salvatore Pucciarelli, Mariavittoria Enzo, Marta Briarava, Roberta Seraglia, Eugenio Ragazzi, Pietro Traldi, Laura Molin, Emanuele Damiano Urso, Isabella Mammi, Alessandra Viel, Mario Lise, Ennio Tasciotti, Alessandra Biasiolo, Patrizia Pontisso, Donato Nitti   +16 more
doaj   +1 more source

Germline Missense Changes in the APC Gene and Their Relationship to Disease

Hereditary Cancer in Clinical Practice, 2004
Familial adenomatous polyposis (FAP) is characterized by the presence of hundreds to thousands of adenomas that carpet the entire colon and rectum. Nonsense and frameshift mutations in the adenomatous polyposis coli (APC) gene account for the majority of
Scott Rodney J, Crooks Renee, Rose Lindy, Attia John, Thakkinstian Ammarin, Thomas Lesley, Spigelman Allan D, Meldrum Cliff J   +7 more
doaj   +1 more source

The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules

Proceedings of the National Academy of Sciences, 1998
The evolutionarily conserved protein EB1 originally was identified by its physical association with the carboxyl-terminal portion of the adenomatous polyposis coli (APC) tumor suppressor protein, an APC domain commonly mutated in familial and sporadic forms of colorectal neoplasia.
Lisbeth Berrueta, Stine-Katherine Kraeft, Jennifer S. Tirnauer, Scott C. Schuyler, Lan Bo Chen, David E. Hill, David Pellman, Barbara E. Bierer   +7 more
openalex   +5 more sources

Expression Profiling of Proliferation and Apoptotic Markers along the Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis Patients

Gastroenterology Research and Practice, 2013
Introduction. Familial adenomatous polyposis (FAP) patients have a germline mutation in the adenomatous polyposis coli (APC) gene. The APC protein interacts with beta-catenin, resulting in the activation of the Wnt signalling pathway.
Jayson Wang, Nabil El-Masry, Ian Talbot, Ian Tomlinson, Malcolm R. Alison, Mona El-Bahrawy   +5 more
doaj   +1 more source

Rare mutations predisposing to familial adenomatous polyposis in Greek FAP patients

BMC Cancer, 2005
Background Familial Adenomatous Polyposis (FAP) is caused by germline mutations in the APC (Adenomatous Polyposis Coli) gene. The vast majority of APC mutations are point mutations or small insertions / deletions which lead to truncated protein products.
Danielidis Ioannis, Triantafillidis John K, Petropoulos Konstantinos, Koliopanos Alexander, Psychias Aristidis, Velissariou Voula, Dauwerse Hans, Apessos Angela, Mihalatos Markos, Fountzilas George, Agnantis Niki J, Nasioulas Georgios   +11 more
doaj   +1 more source

The Ubiquitin-Proteasome Pathway and Serine Kinase Activity Modulate Adenomatous Polyposis Coli Protein-mediated Regulation of β-Catenin-Lymphocyte Enhancer-binding Factor Signaling*

Journal of Biological Chemistry, 1999
The tumor suppressor function of the adenomatous polyposis coli protein (APC) depends, in part, on its ability to bind and regulate the multifunctional protein, β-catenin.
V. Easwaran, Virginia Song, P. Polakis, S. Byers   +3 more
semanticscholar   +1 more source

Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance [PDF]

Journal of Cell Science, 2013
Since its discovery as the major tumour suppressor in colorectal cancer, the adenomatous polyposis coli (APC) protein has emerged as a multi-functional protein that directly or indirectly regulates the cellular processes that govern epithelial tissues ([McCartney and Nathke, 2008][1]).
Nelson, Scott, Näthke, Inke S.
openaire   +3 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

APC orchestrates microtubule dynamics by acting as a positive regulator of KIF2A and a negative regulator of CLASPs

Cell Insight
Tumor suppressor protein Adenomatous polyposis coli protein (APC) is an EB-binding and microtubule (MT) plus end-tracking protein; however, how exactly APC regulates MT dynamics remains elusive.
Yong Wang, Xinping Liu, Zheng Liu, Shasha Hua, Kai Jiang   +4 more
doaj   +1 more source

Mammalian diaphanous-related formin 1 regulates GSK3β-dependent microtubule dynamics required for T cell migratory polarization. [PDF]

PLoS ONE, 2013
The mammalian diaphanous-related formin (mDia1), a Rho-regulated cytoskeletal modulator, has been shown to promote T lymphocyte chemotaxis and interaction with antigen presenting cells, but the mechanisms underpinning mDia1 roles in these processes have ...
Baoxia Dong, Steven S Zhang, Wen Gao, Haichun Su, Jun Chen, Fuzi Jin, Ajay Bhargava, Xiequn Chen, Lars Jorgensen, Arthur S Alberts, Jinyi Zhang, Katherine A Siminovitch   +11 more
doaj   +1 more source