Results 1 to 10 of about 617,017 (357)
Adenosine-Metabolizing Enzymes, Adenosine Kinase and Adenosine Deaminase, in Cancer [PDF]
Biomolecules, 2022 The immunosuppressive effect of adenosine in the microenvironment of a tumor is well established. Presently, researchers are developing approaches in immune therapy that target inhibition of adenosine or its signaling such as CD39 or CD73 inhibiting antibodies or adenosine A2A receptor antagonists.
Galina Zhulai +3 more
openaire +4 more sources
Adenosine Metabolism: Emerging Concepts for Cancer Therapy
Cancer Cell, 2019 Adenosine is a key metabolic and immune-checkpoint regulator implicated in the tumor escape from the host immune system. Major gaps in knowledge that impede the development of effective adenosine-based therapeutics include: (1) lack of consideration of ...
Detlev Boison, Gennady G Yegutkin
exaly +2 more sources
Adenosine receptors as therapeutic targets
Nature Reviews Drug Discovery, 2006 Kenneth A Jacobson
exaly +2 more sources
Neuropathic pain: Mechanisms and therapeutic strategies
Frontiers in Cell and Developmental Biology, 2023 The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited.
Georg A. Petroianu +2 more
doaj +1 more source
Recent advancements in the practice of neuroanaesthesia and neurocritical care: An update
Indian Journal of Anaesthesia, 2023 The practice of neuroanaesthesia has expanded significantly in recent years to keep up with various challenges posed in the perioperative care of patients for neurosurgical, interventional, neuroradiological, and diagnostic procedures.
Manikandan Sethuraman +5 more
doaj +1 more source
Contemporary notions on the role of 5'-nucleotidase in pregnancy
Russian Open Medical Journal, 2022 The review aimed at pooling together available information on 5'-nucleotidase – an enzyme hydrolyzing ribo- and deoxyribonucleoside-5'-monophosphates. The most important product of 5'-nucleotidase activity is adenosine.
Inna V. Dovzhikova +1 more
doaj +1 more source
Multi‐Functional Small Molecule Alleviates Fracture Pain and Promotes Bone Healing
Advanced Science, 2023 Bone injuries such as fractures are one major cause of morbidities worldwide. A considerable number of fractures suffer from delayed healing, and the unresolved acute pain may transition to chronic and maladaptive pain.
Yu‐Ru V. Shih +6 more
doaj +1 more source
ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain
Pharmacological Reviews, 2022 Adenosine is an evolutionary ancient metabolic regulator linking energy state to physiologic processes, including immunomodulation and cell proliferation. Tumors create an adenosine-rich immunosuppressive microenvironment through the increased release of
G. Yegutkin, D. Boison
semanticscholar +1 more source
Медицина неотложных состояний, 2023 Background. Patients diagnosed with an ST-elevation myocardial infarction and type 2 diabetes mellitus present a complex clinical scenario with an increased risk of adverse cardiovascular outcomes.
M.V. Bielinskyi +4 more
doaj +1 more source
Adenosine-A2A Receptor Pathway in Cancer Immunotherapy
Frontiers in Immunology, 2022 A2A receptors (A2AR), a typical GPCR with a high affinity for adenosine, was expressed in many immune cells, such as regulatory T cells, cytotoxic T cells, macrophages, etc.
Chang Sun, Bochu Wang, Shilei Hao
semanticscholar +1 more source