Resetting intrinsic purinergic modulation of neural activity: an associative mechanism? [PDF]
, 2002 The purines, ATP and adenosine, control the rundown and termination of swimming in the Xenopus embryo. This intrinsic purinergic modulation, unavoidably present during every swimming episode, could lead to stereotyped inflexible behavior and consequently
Dale, Nicholas
core +1 more source
Nature Communications, 2017 Osteoarthritis (OA) is characterized by cartilage destruction and chondrocytes have a central role in this process. With age and inflammation chondrocytes have reduced capacity to synthesize and maintain ATP, a molecule important for cartilage ...
C. Corciulo +7 more
semanticscholar +1 more source
Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies
Aging and Cancer, EarlyView.This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal +8 more
wiley +1 more source
ATP Hysteresis in Tripartite Synapses [PDF]
arXiv, 2009 Recent experimental studies strongly suggest the influence of glial purinergic transmission in the modulation of synaptic dynamics. By releasing adenosine triphosphate (ATP), which accumulates as adenosine, astrocytes tonically suppressed synaptic transmission. The delayed multi-step feedback of the glial adenosine with the neuron suggest the existence
arxiv
Direct Growth Graphene on Cu Nanoparticles by Chemical Vapor Deposition as Surface-Enhanced Raman Scattering Substrate for Label-Free Detection of Adenosine [PDF]
arXiv, 2015 We present a graphene/Cu nanoparticle hybrids (G/CuNPs) system as a surface-enhanced Raman scattering (SERS) substrate for adenosine detection. The Cu nanoparticles wrapped around a monolayer graphene shell were directly synthesized on flat quartz by chemical vapor deposition in a mixture of methane and hydrogen.
arxiv
Temperoammonic stimulation depotentiates Schaffer collateral LTP via p38 MAPK downstream of adenosine A1 receptors [PDF]
, 2019 We previously found that low-frequency stimulation of direct temperoammonic (TA) inputs to hippocampal area CA1 depotentiates previously established long-term potentiation in the Schaffer collateral (SC) pathway through complex signaling involving ...
Izumi, Yukitoshi, Zorumski, Charles F
core +1 more source
Comparison between adenosine triphosphate bioluminescence and aerobic colony count to assess surface sanitation in the hospital environment [PDF]
, 2018 Background: Adenosine triphosphate bioluminescence produced by the firefly luciferase has been successfully introduced to verify cleaning procedures in the food industry according to the Hazard Analysis Critical Control Point program.
Alagna E. +8 more
core +1 more source
Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy.
New England Journal of Medicine, 2014 BACKGROUND Polyarteritis nodosa is a systemic necrotizing vasculitis with a pathogenesis that is poorly understood. We identified six families with multiple cases of systemic and cutaneous polyarteritis nodosa, consistent with autosomal recessive ...
Paulina Navon Elkan +34 more
semanticscholar +1 more source
Computational Study of Molecular Mechanisms of Caffeine Actions [PDF]
arXiv, 2015 Caffeine (CAF) is one of the most widely and regularly consumed biologically active substances. We use computer simulation approach to the study of CAF activity by searching for its possible complexes with biopolymer fragments. The principal CAF target at physiologically important concentrations refers to adenosine receptors.
arxiv
Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7. [PDF]
, 2018 Kinesin-4 motors play important roles in cell division, microtubule organization, and signaling. Understanding how motors perform their functions requires an understanding of their mechanochemical and motility properties.
Blasius, T Lynne +7 more
core +2 more sources