Results 51 to 60 of about 559,924 (346)

Mycobacterial adenosine kinase is not a typical adenosine kinase [PDF]

FEBS Letters, 2009
Adenosine kinase (AK) is only found in eukaryotes. Recently, a Mycobacterium tuberculosis (MTub) protein exhibiting greater sequence similarity to ribokinases (RK) was identified as AK. We have expressed AKs from MTub, human and Chinese hamster (CH) cells in Escherichia coli and also AK from human and MTub in AK‐deficient CH cells. While both E.
Bhag Singh, Jae Park, Radhey S. Gupta
openaire   +3 more sources

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Inosine as a Tool to Understand and Treat Central Nervous System Disorders: A Neglected Actor?

Frontiers in Neuroscience, 2021
Since the 1970s, when ATP was identified as a co-transmitter in sympathetic and parasympathetic nerves, it and its active metabolite adenosine have been considered relevant signaling molecules in biological and pathological processes in the central ...
Francisney Pinto Nascimento, Sérgio José Macedo-Júnior, Fernanda Rocha Lapa-Costa, Fernando Cezar-dos-Santos, Adair R. S. Santos   +4 more
doaj   +1 more source

Adenosine A2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer.

Cancer Discovery, 2019
Adenosine mediates immunosuppression within the tumor microenvironment through triggering adenosine 2A receptors (A2AR) on immune cells. To determine whether this pathway could be targeted as an immunotherapy, we performed a phase 1 clinical trial with a
L. Fong, A. Hotson, J. Powderly, M. Sznol, R. Heist, T. Choueiri, S. George, B. Hughes, M. Hellmann, D. Shepard, B. Rini, S. Kummar, A. Weise, Matthew J. Riese, B. Markman, L. Emens, D. Mahadevan, J. Luke, G. Laport, J. Brody, L. Hernandez-Aya, P. Bonomi, J. Goldman, L. Berim, D. Renouf, R. Goodwin, Brian Munneke, P. Ho, J. Hsieh, I. McCaffery, L. Kwei, S. Willingham, Richard A. Miller   +32 more
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

Frontiers in Immunology, 2016
Within tumors, some areas are less oxygenated than others. Since their home ground is under chronic hypoxia, tumor cells adapt to this condition by activating aerobic glycolysis; however, this hypoxic environment is very harsh for incoming immune cells ...
A. Ohta
semanticscholar   +1 more source

Adenosine and adenosine receptors in rheumatoid arthritis

International Journal of Clinical Rheumatology, 2013
Rheumatoid arthritis is one of the most important chronic, progressive and disabling inflammatory diseases characterized by joint destructive process associated with synovial proliferation and secretion of high levels of proinflammatory mediators including cytokines and growth factors.
PADOVAN, Melissa, VINCENZI, Fabrizio, GOVONI, Marcello, BORTOLUZZI, Alessandra, BOREA, Pier Andrea, VARANI, Katia   +5 more
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Cyp2j5-Gene Deletion Affects on Acetylcholine and Adenosine-Induced Relaxation in Mice: Role of Angiotensin-II and CYP-Epoxygenase Inhibitor

Frontiers in Pharmacology, 2020
Previously, we showed vascular endothelial overexpression of human-CYP2J2 enhances coronary reactive hyperemia in Tie2-CYP2J2 Tr mice, and eNOS−/− mice had overexpression of CYP2J-epoxygenase with adenosine A2A receptor-induced enhance relaxation, but we
Stephanie Agba, Ahmad Hanif, Matthew L. Edin, Darryl C. Zeldin, Mohammed A. Nayeem   +4 more
doaj   +1 more source

Targeting Adenosine Receptor Signaling in Cancer Immunotherapy

International Journal of Molecular Sciences, 2018
The immune system plays a major role in the surveillance and control of malignant cells, with the presence of tumor infiltrating lymphocytes (TILs) correlating with better patient prognosis in multiple tumor types. The development of ‘checkpoint blockade’
K. Sek, C. Mølck, Gregory D. Stewart, Lev M. Kats, P. Darcy, P. Beavis   +5 more
semanticscholar   +1 more source