Results 101 to 110 of about 68,176 (222)

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

The FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John van Swieten, Rodrigo Maillard, Friedrich W. Herberg, Ronit Ilouz   +13 more
wiley   +1 more source

Lack of efficacy of a partial adenosine A1 receptor agonist in neuropathic pain models in mice. [PDF]

Purinergic Signal, 2021
Metzner K, Gross T, Balzulat A, Wack G, Lu R, Schmidtko A.   +5 more
europepmc   +1 more source

Genome‐Wide Association Study of Atrial Fibrillation Recurrence After Radiofrequency Catheter Ablation in a Japanese Population

Journal of Cardiovascular Electrophysiology, EarlyView.
This study aimed to identify the factors associated with atrial fibrillation (AF) recurrence after catheter ablation. The clinical information analysis revealed persistent AF, nonpulmonary AF triggers, NT‐proBNP levels, and the left atrial volume were clinical predictors of recurrence.
Takumi Sakai, Motoki Furutani, Mika Nakashima, Naoki Ishibashi, Junji Maeda, Naoto Oguri, Shogo Miyamoto, Shunsuke Miyauchi, Sho Okamura, Yousaku Okubo, Takehito Tokuyama, Noboru Oda, Risa Mitsumori, Shumpei Niida, Kouichi Ozaki, Daichi Shigemizu, Yukiko Nakano   +16 more
wiley   +1 more source

Adenosine A1 Receptor Deficiency Aggravates Extracellular Matrix Accumulation in Diabetic Nephropathy through Disturbance of Peritubular Microenvironment. [PDF]

J Diabetes Res, 2021
Tian D, Li J, Zou L, Lin M, Shi X, Hu Y, Lang J, Xu L, Ye W, Li X, Chen L.   +10 more
europepmc   +1 more source

Interaksi Teofilin Ekstrak Daun Teh (Camellia sinensis ) dengan Adenosine A1 receptor dalam Menghambat Penyakit Asma [PDF]

Penelitian ini bertujuan untuk mengeksplorasi potensi interaksi teofilin yang diekstraksi dari daun teh (Camellia sinensis) dengan Adenosine A1 receptor dalam upaya menghambat penyakit asma.
Suryani, Okta, Verawati, Rismi
core   +1 more source

Modulation of Sodium and Ammonia Transporters in the Context of Viral Gill Diseases in Common Carp (Cyprinus carpio)

Journal of Fish Diseases, EarlyView.
ABSTRACT Osmoregulation and ammonia removal are among key physiological processes that take place in gills and affect fish homeostasis and well‐being. These processes can be disrupted by numerous environmental factors, but also by viral infections, especially those leading to severe gill disorders.
Maria Zawisza, Muhammad Abdullah, Magdalena Marcinkowska, Marek Matras, Krzysztof Rakus, Mikolaj Adamek   +5 more
wiley   +1 more source

The full activation mechanism of the adenosine A₁ receptor revealed by GaMD and Su-GaMD simulations. [PDF]

Proc Natl Acad Sci U S A, 2022
Li Y, Sun J, Li D, Lin J.
europepmc   +1 more source

N3-substituted xanthines as irreversible adenosine receptor antagonists

, 2000
8-Cyclopentyl-3-(3-(4-fluorosulfonylbenzoyl)oxy)propyl-propylxanthine (44, FSCPX) has been reported to exhibit potent and selective irreversible antagonism of the A1 adenosine receptor when using in vitro biological preparations.
Beauglehole, Anthony Robert.
core  

Refuting a Temporal Correlation: Interictal Epileptic Discharges Do Not Preferentially Occur During Respiratory Events in Patients With Sleep‐Related Breathing Disorder and Epilepsy

Journal of Sleep Research, EarlyView.
ABSTRACT The bidirectional interaction between sleep and epilepsy is well known. In particular, it has been established that sleep apnea can worsen epilepsy, whereas sleep apnea (SA) treatment has a beneficial effect on seizure control. However, the exact mechanisms whereby SA promotes epileptic seizures are unknown.
Christian M. Horvath, Hristina Drangova, Jakub Stefela, Carolin Schäfer, Frederic Zubler   +4 more
wiley   +1 more source

Discovery and Structure-Activity Relationship Studies of Novel Adenosine A₁ Receptor-Selective Agonists. [PDF]

J Med Chem, 2022
Preti B, Suchankova A, Deganutti G, Leuenberger M, Barkan K, Manulak I, Huang X, Carvalho S, Ladds G, Lochner M.   +9 more
europepmc   +1 more source