Results 111 to 120 of about 127,904 (323)

The Selective Antagonism of Adenosine A2B Receptors Reduces the Synaptic Failure and Neuronal Death Induced by Oxygen and Glucose Deprivation in Rat CA1 Hippocampus in Vitro

Frontiers in Pharmacology, 2018
Ischemia is a multifactorial pathology characterized by different events evolving in time. Immediately after the ischemic insult, primary brain damage is due to the massive increase of extracellular glutamate.
Irene Fusco, Filippo Ugolini, Daniele Lana, Elisabetta Coppi, Ilaria Dettori, Lisa Gaviano, Daniele Nosi, Federica Cherchi, Felicita Pedata, Maria G. Giovannini, Anna M. Pugliese   +10 more
doaj   +1 more source

Biomarker profiles of acute heart failure patients with a mid-range ejection fraction [PDF]

, 2017
OBJECTIVES: In this study, the authors used biomarker profiles to characterize differences between patients with acute heart failure with a midrange ejection fraction (HFmrEF) and compare them with patients with a reduced (heart failure with a ...
Bloomfield, Daniel M, Cleland, John G.F., Cotter, Gad, Davison, Beth, Dittrich, Howard C, Givertz, Michael M, Hillege, Hans L, Khan, Mohsin A F, Mentz, Robert J, Metra, Marco, O'Connor, Christopher M, Ponikowski, Piotr, Teerlink, John R, Tromp, Jasper, van der Meer, Peter, Van Veldhuisen, Dirk J, Voors, Adriaan A.   +16 more
core   +2 more sources

Exploiting glial cell functions for neurodegeneration therapy

Neuroprotection, EarlyView.
The figure illustrates the potential of targeting glial cell functions and their interactions with neurons as a therapeutic strategy for neurodegeneration. Abstract Glial cells, alongside neurons, are the major cells of the central nervous system.
Tobiloba S. Olajide
wiley   +1 more source

Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation [PDF]

, 2006
©2006 Society for NeurosciencePrevious studies have shown that cortical stimulation selectively activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and immediate early gene expression in striatal GABAergic enkephalinergic neurons.
Ferré, Sergi, Goldberg, Steven R., Gomes, Catarina, Hope, Bruce T., Pak, Arlene C., Quiroz, César, Ribeiro, Joaquim A.   +6 more
core   +1 more source

Characterization of Visceral Adipose Tissue Proteome Reveals Metabolic Changes and Inflammatory Signatures in Severe Obesity

Obesity, EarlyView.
ABSTRACT Objective Severe obesity poses a major public health concern due to its links with cardiometabolic complications and mortality. Visceral adipose tissue (VAT) plays a key role in these processes through distinct molecular features. This study aimed to characterize the VAT proteome of individuals with severe obesity and investigate its ...
Prince Dadson, Miikka‐Juhani Honka, Tomi Suomi, Anne Rokka, Saila Kauhanen, Paulina Salminen, Mika Helmiö, Peter James, Laura L. Elo, Vesa M. Olkkonen, Pirjo Nuutila   +10 more
wiley   +1 more source

Mechanisms of Volatile Anesthetic-Induced Myocardial Protection [PDF]

, 2003
Volatile anesthetics protect myocardium against reversible and irreversible ischemic injury. Experimental evidence from several in vitro and in vivo animal models demonstrates that volatile agents enhance the recovery of stunned myocardium and reduce the
Gu, Weidong, Kersten, Judy R., LaDisa, John F., Ludwig, Lynda M., Pagel, Paul S., Tanaka, Katsuya, Warltier, David C.   +6 more
core   +1 more source

Renal pericytes: regulators of medullary blood flow [PDF]

, 2012
Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli.
Agmon Y., Beach R.E., Biondi M., Burnstock G., Casellas D., Cohen H.J., Edwards R.M., Guan Z., Harrison‐Bernard L.M., Harrison‐Bernard L.M., Jamison R.L., Kreisberg M.S., Kriz W., Larson T.S., Lazarowski E.R., Lerman L.O., Majid D.S., Pallone T.L., Rouget C., Seldin D.W., Stern M.D., Strick D.M., Takenaka T., Takezawa K., Turner M.R., Unwin R.J., Yamagishi S., Yang S.   +27 more
core   +1 more source

Expanding the Reach of Membrane Protein–Ligand Interaction Studies Through the Integration of Mass Spectrometry and Membrane Mimetics

PROTEOMICS, EarlyView.
ABSTRACT Mass spectrometry (MS) offers robust, label‐free approaches for characterizing ligand–protein interactions through two main strategies: affinity‐based and stability‐based assays. However, their application to membrane proteins (MPs)—a major class of drug targets—has been limited by challenges such as structural complexity, low native ...
Jonathon C. Lambos, Ashim Bhattacharya, Mohammed Al‐Seragi, Franck Duong van Hoa   +3 more
wiley   +1 more source

Role of adenosine in the antiepileptic effects of deep brain stimulation

Frontiers in Cellular Neuroscience, 2014
Despite the effectiveness of anterior thalamic nucleus (AN) deep brain stimulation (DBS) for the treatment of epilepsy, mechanisms responsible for the antiepileptic effects of this therapy remain elusive.
Maisa eMiranda, Clement eHamani, Clement eHamani, Antonio-Carlos eAlmeida, Beatriz eAmorim, Carlos eMacedo, Maria Jose eFernandes, Jose eNobrega, Mayra eAarao, Ana Paula eAntonio, Antonio eRodrigues, Monica L Andersen, Sergio eTufik, Luiz E Mello, Luciene eCovolan   +14 more
doaj   +1 more source

Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice [PDF]

, 2009
© 2009 Nature Publishing Group All rights reservedPrevious in vitro studies have characterized the electrophysiological and molecular signaling pathways of adenosine tonic modulation on long-lasting synaptic plasticity events, particularly for
A de Mendonça, A de Mendonça, A Gruart, A Gruart, A Monopoli, Agnès Gruart, AM Sebastião, AM Thomson, Ana M Sebastião, BM Fontinha, Bruno M Fontinha, C Zocchi, CC Fernandes, CD Woody, CS Rex, DKJE von Lubitz, E Dominguez-del-Toro, E Porras-García, ER Kandel, F Engert, F Suzuki, FS Lee, G Burnstock, G Neves, G Paxinos, GG Turrigiano, HJ Normile, I Gureviciene, I Sahún, JA Ribeiro, JE Kelsey, JM Delgado-Garcia, Joaquim A Ribeiro, José M Delgado-García, JR Whitlock, K Kessey, K Kessey, K Takatsuki, L Boulanger, L Connole, L Winsky, M de Jonge, M El Yacoubi, M El Yacoubi, M Ohno, M Yang, MJ Diógenes, MJ Diógenes, MT Tebano, MT Tebano, N Madroñal, N Rebola, Noelia Madroñal, O Dall'Igna, PA Schwartzkroin, RF Thompson, RS Zucker, S Ferré, S Maren, S Mingote, SR Kopf, T Sakamoto, TV Bliss, TVP Bliss, W Tseng, Y Kishimoto, Y Kishimoto, Y Sekino, Y Wang   +68 more
core   +1 more source