Results 111 to 120 of about 68,176 (222)

Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy

Journal of Sleep Research, EarlyView.
ABSTRACT Throughout history, the development of new sleep medicines has been driven by progress in our understanding of the mechanisms underlying sleep. Ancient civilisations used their understanding of the sedative nature of natural herbs and compounds to induce sleep.
Brooke A. Prakash, Ishani Shah, Guohao Ni, Sridhar Vasudevan, Aarti Jagannath, Russell G. Foster   +5 more
wiley   +1 more source

Altered Heterosynaptic Plasticity Impairs Visual Discrimination Learning in Adenosine A1 Receptor Knock-Out Mice. [PDF]

J Neurosci, 2021
Chasse R, Malyshev A, Fitch RH, Volgushev M.   +3 more
europepmc   +1 more source

Neuronal Adenosine A₁ Receptor is Critical for Olfactory Function but Unable to Attenuate Olfactory Dysfunction in Neuroinflammation. [PDF]

Front Cell Neurosci, 2022
Schubert C, Schulz K, Träger S, Plath AL, Omriouate A, Rosenkranz SC, Morellini F, Friese MA, Hirnet D.   +8 more
europepmc   +1 more source

Molecular Mechanisms of Peritoneal Dialysis–Induced Microvascular Vasodilation [PDF]

, 2014
Peritoneal dialysis (PD) solutions dilate microvessels by undefined mechanisms. This vasodilation directly affects ultrafiltration and solute exchange during a PD dwell and is thought to account for the variable mass transfer area coefficient for ...
Al-Thani, Asma, Fawzi, Ashraf, Fituri, Omar, Zakaria, El Rasheid   +3 more
core  

Rapid osmocontractile response of motor cells of Mimosa pudica pulvini induced by short light signals

Photochemistry and Photobiology, Volume 101, Issue 3, Page 728-745, May/June 2025.
White light signals lasting less than 30 s induced rapid drop (1 s) of some Mimosa pudica leaves, resulting from osmocontraction of the pulvinar motor cells (A). An early signal detected after about 5 s is a change in motor cell membrane potential, depending on the wavelength applied (B).
Gabriel Roblin, Christelle Moyen, Pierrette Fleurat‐Lessard, Fabienne Dédaldéchamp   +3 more
wiley   +1 more source

Selective activation of Gαob by an adenosine A₁ receptor agonist elicits analgesia without cardiorespiratory depression. [PDF]

Nat Commun, 2022
Wall MJ, Hill E, Huckstepp R, Barkan K, Deganutti G, Leuenberger M, Preti B, Winfield I, Carvalho S, Suchankova A, Wei H, Safitri D, Huang X, Imlach W, La Mache C, Dean E, Hume C, Hayward S, Oliver J, Zhao FY, Spanswick D, Reynolds CA, Lochner M, Ladds G, Frenguelli BG.   +24 more
europepmc   +1 more source

The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection [PDF]

, 2009
The rat embryonic cardiomyoblast-derived H9c2 cell line is increasingly used for studies into cardioprotection, as these cells display similar properties to primary cardiomyocytes.
Fretwell, LV
core  

Overexpression of jojoba wax ester synthase in poplar increases foliar lipid accumulation, alters stomatal conductance, and increases water use efficiency

Plant Biology, EarlyView.
Overexpression of jojoba wax ester synthase in poplar causes accumulation of intracellular lipids in leaves and reduced stomatal conductance with higher water‐use efficiencies in the transgenic lines. Abstract Poplars are important fast‐growing, water‐spending biomass tree crops.
A. Amirkhosravi, G.‐J. Strijkstra, A. Keyl, F. Häffner, U. Lipka, C. Herrfurth, I. Feussner, A. Polle   +7 more
wiley   +1 more source

Adenosine A_2A Receptors Shut Down Adenosine A₁ Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation. [PDF]

Biomolecules, 2023
Lopes CR, Gonçalves FQ, Olaio S, Tomé AR, Cunha RA, Lopes JP.   +5 more
europepmc   +1 more source

How much furosemide should be administered to prevent transfusion‐associated circulatory overload? Results of a dose‐finding study

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Transfusion‐associated circulatory overload (TACO) is a common and life‐threatening transfusion complication. Because of uncertainty regarding dosing, pre‐transfusion furosemide prophylaxis is not widely endorsed. The aim of this study was to generate a furosemide dose–response curve in TACO‐susceptible patients using
Lianne Rotin, Liying Zhang, Chantal Armali, Amie Malkin, Sophia Massin, Harley Meirovich, Daniel Roque, Samia Saeed, Shangari Vijenthira, Yulia Lin, Jacob Pendergrast   +10 more
wiley   +1 more source