Results 121 to 130 of about 31,304 (262)

Adenosine A1 Receptor Deficiency Aggravates Extracellular Matrix Accumulation in Diabetic Nephropathy through Disturbance of Peritubular Microenvironment. [PDF]

J Diabetes Res, 2021
Tian D, Li J, Zou L, Lin M, Shi X, Hu Y, Lang J, Xu L, Ye W, Li X, Chen L.   +10 more
europepmc   +1 more source

Iodine-125-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors

, 1988
Joel Linden, Amrat Patel, Craig Q. Earl, Rebecca H. Craig, Susan M. Daluge   +4 more
openalex   +1 more source

A1 Adenosine Receptor Partial Agonists and Allosteric Modulators: Advancing Toward the Clinic? [PDF]

, 2020
Fabrizio Vincenzi, Silvia Pasquini, Enrica Battistello, Stefania Merighi, Stefania Gessi, Pier Andrea Borea, Katia Varani   +6 more
openalex   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

The full activation mechanism of the adenosine A₁ receptor revealed by GaMD and Su-GaMD simulations. [PDF]

Proc Natl Acad Sci U S A, 2022
Li Y, Sun J, Li D, Lin J.
europepmc   +1 more source

The agonist affinity state of A1 adenosine receptors is influenced byprotonation

, 1990
Edmund Hoppe, Martin Reddington
openalex   +1 more source

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

Journal of Internal Medicine, Volume 299, Issue 3, Page 302-327, March 2026.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source

Discovery and Structure-Activity Relationship Studies of Novel Adenosine A₁ Receptor-Selective Agonists. [PDF]

J Med Chem, 2022
Preti B, Suchankova A, Deganutti G, Leuenberger M, Barkan K, Manulak I, Huang X, Carvalho S, Ladds G, Lochner M.   +9 more
europepmc   +1 more source

Photoaffinity labeling of A1-adenosine receptors.

, 1985
Karl‐Norbert Klotz, G. Cristalli, Mario Grifantini, Sauro Vittori, Martin J. Lohse   +4 more
openalex   +1 more source

Adenosine Receptor A1 [PDF]

, 2020
openaire   +1 more source