Results 121 to 130 of about 124,204 (359)

Involvement of Adenosine A2a Receptor in Intraocular Pressure Decrease Induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-Cyano-1-hexyn-1-yl)adenosine

Journal of Pharmacological Sciences, 2005
The aim of the present study is to clarify the mechanism for the decrease in intraocular pressure by 2-alkynyladenosine derivatives in rabbits. The receptor binding analysis revealed that 2-(1-octyn-1-yl)adenosine (2-O-Ado) and 2-(6-cyano-1-hexyn-1-yl ...
Takashi Konno, Akira Murakami, Takehiro Uchibori, Akihiko Nagai, Kentaro Kogi, Norimichi Nakahata   +5 more
doaj  

Adenosine A_2A receptor binding profile of two antagonists, ST1535 and KW6002: consideration on the presence of atypical adenosine A_2A binding sites

Frontiers in Psychiatry, 2010
Adenosine A2A receptors seem to exist in typical (more in striatum) and atypical (more in hippocampus and cortex) subtypes. In the present study, we investigated the affinity of two adenosine A2A receptor antagonists, ST1535 [2 butyl -9-methyl-8-(2H-1,2 ...
Teresa Riccioni, Fabiana Leonardi, Franco Borsini   +2 more
doaj   +1 more source

Insights Into Effects of Natural Bioactive Components on Inflammatory Diseases in Respiratory Tract

Phytotherapy Research, EarlyView.
ABSTRACT The increasing prevalence of inflammatory diseases in the respiratory tract worldwide has raised concerns, and due to its high prevalence and poor prognosis, it remains a clinical focus and research hotspot. These inflammatory diseases include airway inflammation, asthma, bacterial antigens‐induced tonsil epithelial inflammation, chronic ...
Jincan Luo, Jinhai Luo, Zhonghao Fang, Yu Fu, Baojun (Bruce) Xu   +4 more
wiley   +1 more source

A központi idegrendszer és a myocardium szabályozásában szerepet játszó adenozin-receptorok és PET izotóppal jelölt ligandjaik kötődés kinetikájának vizsgálata PET technikával = PET investigation of the binding kinetics of PET isotope-labelled ligands and adenosine receptors involved in the regulation of myocardial and CNS function [PDF]

, 2006
Az adenozin-receptorok alapvető szerepet játszanak a központi idegrendszer és a szívizom működésének szabályozásában. Célunk az in vivo PET vizsgálatokra alkalmas adenozin-receptor ligandok előállítása és biológiai tesztelése volt.
Balkay, László, Krasznai, Zoltán, Lengyel, Zsolt, Márián, Teréz, Trón, Lajos   +4 more
core  

The Selective Antagonism of Adenosine A2B Receptors Reduces the Synaptic Failure and Neuronal Death Induced by Oxygen and Glucose Deprivation in Rat CA1 Hippocampus in Vitro

Frontiers in Pharmacology, 2018
Ischemia is a multifactorial pathology characterized by different events evolving in time. Immediately after the ischemic insult, primary brain damage is due to the massive increase of extracellular glutamate.
Irene Fusco, Filippo Ugolini, Daniele Lana, Elisabetta Coppi, Ilaria Dettori, Lisa Gaviano, Daniele Nosi, Federica Cherchi, Felicita Pedata, Maria G. Giovannini, Anna M. Pugliese   +10 more
doaj   +1 more source

Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons

Small Science, EarlyView.
This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong, Yanyi Peng, Lingyue Zhang, Bo Xiao, Mengqi Zhang   +4 more
wiley   +1 more source

Blockierung von Carbamazepin-resistenter epileptiformer Aktivität durch Aktivierung von Adenosin A1 Rezeptoren in humanen neokortikalen Hirnschnitten von pharmakoresistenten Epilepsiepatienten [PDF]

, 2017
Introduction: Resistance to antiepileptic drugs is a major clinical problem affecting about 30 % of all epilepsy patients and up to 80 % of patients suffering from temporal lobe epilepsy.
Klaft, Zin-Juan
core   +1 more source

Upregulation of AMPA receptor GluA1 phosphorylation by blocking adenosine A1 receptors in the male rat forebrain

Brain and Behavior, 2020
Objective The adenosine A1 receptor is a Gαi/o protein‐coupled receptor and inhibits upon activation cAMP formation and protein kinase A (PKA) activity. As a widely expressed receptor in the mammalian brain, A1 receptors are implicated in the modulation ...
Li‐Min Mao, John Q. Wang
doaj   +1 more source

Adenosine A1 receptor agonists inhibit trigeminovascular nociceptive transmission.

Brain : a journal of neurology, 2002
There is a considerable literature to suggest that adenosine A1 receptor agonists may have anti-nociceptive effects, and we sought to explore the role of adenosine A1 receptors in a model of trigeminovascular nociceptive transmission.
P. Goadsby, K. L. Hoskin, R. Storer, L. Edvinsson, H. Connor   +4 more
semanticscholar   +1 more source

Diagnostics of Autoimmune Hepatitis Enabled by Non‐Invasive Clinical Proteomics

Alimentary Pharmacology &Therapeutics, EarlyView.
Mass‐spectrometry‐based proteomic analyses of paired liver‐plasma samples from patients with AIH enabled discovery of numerous proteins showing high diagnostic accuracy. Proteomics may constitute a novel non‐invasive diagnostic tool for AIH if validated in larger, age‐ and sex‐matched cohorts.
Anne‐Sofie Houlberg Jensen, Henriette Ytting, Annelaura Bach Nielsen, Mikkel Parsberg Werge, Elias Badal Rashu, Liv Eline Hetland, Mira Thing, Puria Nabilou, Johan Burisch, Anders Ellekær Junker, Lise Hobolth, Christian Mortensen, Flemming Tofteng, Flemming Bendtsen, Søren Møller, Mogens Vyberg, Reza Rafiolsadat Serizawa, Marie Winther‐Sørensen, Jesper Sloth Kellemann, Lise Lotte Gluud, Nicolai Jacob Wewer Albrechtsen   +20 more
wiley   +1 more source