Experimental Physiology, EarlyView.Abstract Renal injury is associated with inflammatory responses within the kidney which could involve activation of transient receptor potential vanilloid 1 (TRPV1) channels. This study investigated whether TRPV1 channels modulate baroreflex regulation of renal sympathetic nerve activity (RSNA) in a rat model of cisplatin‐mediated renal injury.
Mohammed H. Abdulla +3 more
wiley +1 more source
Adenosine A1 receptor antagonist-induced facilitation of postsynaptic AMPA currents in pyramidal neurons of the rat hippocampal CA2 area. [PDF]
Purinergic Signal, 2023 Kawamura M, Sekino Y.
europepmc +1 more source
Adenosine A1 receptor is dispensable for hepatocyte glucose metabolism and insulin sensitivity. [PDF]
Biochem Pharmacol, 2021 Jain S +4 more
europepmc +1 more source
Experimental Physiology, EarlyView.Abstract Skeletal muscle fatigue is accompanied by the accumulation of metabolites, such as adenosine diphosphate (ADP), inorganic phosphate (Pi), and protons (H+). However, we lack a comprehensive understanding of the contribution of these metabolic changes to the development of muscle fatigue during intense exercise and the underlying mechanisms.
John I. Hendry +6 more
wiley +1 more source
Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity
The Journal of Physiology, EarlyView.Abstract figure legend Pannexin 1 (PANX1) regulation of dendritic spines. The postnatal decrease in PANX1 expression could release key spine cytoskeleton‐regulating proteins enabling spine stabilization. Does the physiological decrease in neuronal PANX1 levels across brain development underlie dendritic spine maturation?
Adriana Casillas Martinez +3 more
wiley +1 more source
Adaptations to hypoxia in the vertebrate retina
The Journal of Physiology, EarlyView.Abstract figure legend Most animals, including mammals, are susceptible to the damaging effects of hypoxia or ischaemia, where the result is neuronal cell death in the brain. By contrast, some neurons of the mammalian retina are less sensitive to hypoxia. In both brain and retina, neurons may survive if first preconditioned with ischaemia.
Michael G. Jonz
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Epidemiological evidence suggests a link between dementia and cardiovascular health, including the regulation of platelets. To investigate this relationship, we examined how platelet reactivity relates to cerebral neurovascular function and systemic vascular reactivity in healthy older adults.
Gabriella M. K. Rossetti +10 more
wiley +1 more source
Regulation of Arousal by Adenosine A1 and A2A Receptors in the Prefrontal Cortex of C57BL/6J Mouse. [PDF]
Adenosine levels in the basal forebrain and cortex increase with prolonged wakefulness to promote sleep. Caffeine increases wakefulness by blocking adenosine receptors, yet the neurotransmitter systems and brain regions through which adenosine receptor ...
Van Dort, Christa J.
core
Chronic treatment with adenosine A1 receptor antagonist promotes neurogenesis and improves outcome after cerebral ischemia. [PDF]
J Cereb Blood Flow MetabArdaya M +14 more
europepmc +1 more source
Adenosine A1 receptor agonist alleviates cerebral ischemia/reperfusion injury by inhibiting Nrf2/NLRP3 signaling‑mediated pyroptosis. [PDF]
Exp Ther MedMing Q, Li Z, Tan J, Li Y.
europepmc +1 more source