Results 131 to 140 of about 127,904 (323)

WONOEP XVII appraisal: Targeting network excitability beyond the synapse ‐Neurotransmitter, ionic, and electro ‐diffusions

Epilepsia, EarlyView.
Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Vincent Magloire, Marco de Curtis, Jeffrey Noebels, Gilles Huberfeld, Piotr Suffczynski, Vadym Gnatkovsky, Olga Tyurikova, Dominique Durand, David C. Henshall, Cian McCafferty   +9 more
wiley   +1 more source

Reduction of postischemic leukocyte-endothelium interaction by adenosine via A\(_2\) receptor [PDF]

, 1992
The adhesion of leukocytes to the endothelium of postcapillary venules hallmarks a key event in ischemia-reperfusion injury. Adenosine has been shown to protect from postischemic reperfusion injury, presumably through inhibition of postischemic leukocyte-
Klotz, Karl-Norbert, Lehr, H.-A., Lorenzen, A., Messmer, K., Nolte, D., Zimmer, F.-J.   +5 more
core  

Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain [PDF]

, 2007
Sergi Ferré
openalex   +1 more source

ClAPRT3‐Mediated Adenine Salvage Pathway Enhances Purine Metabolites to Sustain Seed Vigour During Selfing in Cunninghamia lanceolata

Plant Biotechnology Journal, EarlyView.
ABSTRACT Selfing often causes inbreeding depression, especially during seed and seedling stages. However, some selfed progeny show low inbreeding depression with enhanced vigour, differing from inbred counterparts. This study investigates the molecular mechanisms maintaining seed vigour during selfing in Cunninghamia lanceolata.
Houyin Deng, Ye Zhao, Jie Liu, Kunjin Han, Juan Han, Meng Ke, Rong Huang, Ruping Wei, Yousry A. El‐Kassaby, Runhui Wang, Shu Yan, Yuhan Sun, Yun Li, Huiquan Zheng   +13 more
wiley   +1 more source

Ex Vivo Feedback Control of Neurotransmission Using a Photocaged Adenosine A1 Receptor Agonist. [PDF]

Int J Mol Sci, 2022
Craey E, Hulpia F, Spanoghe J, Manzella S, Larsen LE, Sprengers M, De Bundel D, Smolders I, Carrette E, Delbeke J, Vonck K, Boon P, Van Calenbergh S, Wadman WJ, Raedt R.   +14 more
europepmc   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Combination Therapy with A1 Receptor Agonist and Vitamin C Improved Working Memory in a Mouse Model of Global Ischemia-Reperfusion

Basic and Clinical Neuroscience, 2013
Introduction: Stroke is one of the most important reasons of death. Hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide.
Mohmmad Zamani, M. Katebi, Mehdi Mehdizadeh, Laya Kafami, Fatemeh Malek, Mansooreh Soleimani   +5 more
doaj  

Cancer-Related Somatic Mutations in Transmembrane Helices Alter Adenosine A1 Receptor Pharmacology. [PDF]

Molecules, 2022
Wang X, Jespers W, Wolff KAN, Buytelaar J, IJzerman AP, van Westen GJP, Heitman LH.   +6 more
europepmc   +1 more source

Effects of acute selective cyclooxygenase‐2 inhibition on skeletal muscle microvascular oxygenation and exercise tolerance

Experimental Physiology, EarlyView.
Abstract The cyclooxygenase (COX) pathway regulates vascular tone and, therefore, local O2 delivery‐utilization matching. The two main isoforms, COX‐1 and COX‐2, may promote opposing effects on contracting muscle O2 transport in health by inducing vasoconstriction and vasodilatation, respectively.
Michael D. Belbis, Michael J. Holmes, Joseph Yao, Christopher W. Kinnick, Christopher K. Kargl, Carly Day, Nicole L. Noel, Timothy P. Gavin, Bruno T. Roseguini, Daniel M. Hirai   +9 more
wiley   +1 more source

Dynamic allosteric networks drive adenosine A₁ receptor activation and G-protein coupling. [PDF]

Elife, 2023
Maria-Solano MA, Choi S.
europepmc   +1 more source