Results 141 to 150 of about 127,904 (323)

Joint Public Review: Dynamic allosteric networks drive adenosine A1 receptor activation and G-protein coupling

, 2023

openalex   +1 more source

TRPV1 blockade restores the baroreflex control of renal sympathetic nerve activity in cisplatin‐induced renal injury in rats

Experimental Physiology, EarlyView.
Abstract Renal injury is associated with inflammatory responses within the kidney which could involve activation of transient receptor potential vanilloid 1 (TRPV1) channels. This study investigated whether TRPV1 channels modulate baroreflex regulation of renal sympathetic nerve activity (RSNA) in a rat model of cisplatin‐mediated renal injury.
Mohammed H. Abdulla, Ella Murphy, Lauren Mulcahy, Edward J. Johns   +3 more
wiley   +1 more source

Potential differences in receptor‐mediated G‐protein activation in postmortem human hippocampal membranes prepared from healthy controls and suicide victims

Neuropsychopharmacology Reports
Aim Postmortem brain studies offer enormous opportunities to study molecular mechanisms associated with suicide. In the present study, conventional [35S]GTPγS binding assay and its version‐up method ([35S]GTPγS binding/immunoprecipitation assay) were ...
Yuji Odagaki, Masakazu Kinoshita, Miklós Palkovits, Dasiel Oscar Borroto‐Escuela, Kjell Fuxe   +4 more
doaj   +1 more source

Clues from a missense mutation of the adenosine A₁ receptor gene associated with early-onset Parkinson's disease. [PDF]

Neural Regen Res, 2023
Ferré S, Pardo L, Ciruela F.
europepmc   +1 more source

Predicted structures of agonist and antagonist bound complexes of adenosine A_3 receptor [PDF]

, 2011
We used the GEnSeMBLE Monte Carlo method to predict ensemble of the 20 best packings (helix rotations and tilts) based on the neutral total energy (E) from a vast number (10 trillion) of potential packings for each of the four subtypes of the adenosine G
Abrol, Ravinder, Goddard, William A., III, Jacobson, Kenneth A., Kim, Soo-Kyung, Riley, Lindsay   +4 more
core   +1 more source

Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor. [PDF]

ACS Pharmacol Transl Sci, 2021
Deganutti G, Barkan K, Preti B, Leuenberger M, Wall M, Frenguelli BG, Lochner M, Ladds G, Reynolds CA.   +8 more
europepmc   +1 more source

Upregulation of Adenosine A1 Receptors Facilitates Sinoatrial Node Dysfunction in Chronic Canine Heart Failure by Exacerbating Nodal Conduction Abnormalities Revealed by Novel Dual-Sided Intramural Optical Mapping [PDF]

, 2014
Qing Lou, Brian J. Hansen, Olga Fedorenko, Thomas A. Csepe, Anuradha Kalyanasundaram, Ning Li, Lori T. Hage, Alexey V. Glukhov, George E. Billman, Raul Weiss, Peter J. Mohler, Sándor Györke, Brandon J. Biesiadecki, Cynthia A. Carnes, Vadim V. Fedorov   +14 more
openalex   +1 more source

Inhibition of adenosine A1 receptors abolished the nutritional ketosis-evoked delay in the onset of isoflurane-induced anesthesia in Wistar Albino Glaxo Rijswijk rats [PDF]

, 2020
Zsolt Kovács, Brigitta Brunner, Dominic P. D’Agostino, Csilla Ari   +3 more
openalex   +1 more source

Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria [PDF]

, 2016
Bruno Bragança, N Oliveira-Monteiro, Fátima Ferreirinha, Pedro A. Lima, Miguel Faria, Ana Patrícia Fontes-Sousa, Paulo Correia‐de‐Sá   +6 more
openalex   +1 more source

Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity

Cell, 2017
A. Glukhova, D. Thal, A. T. Nguyen, E. A. Vecchio, M. Jörg, P. Scammells, L. May, P. Sexton, A. Christopoulos   +8 more
semanticscholar   +1 more source