Results 141 to 150 of about 124,204 (359)

WONOEP XVII appraisal: Targeting network excitability beyond the synapse ‐Neurotransmitter, ionic, and electro ‐diffusions

Epilepsia, EarlyView.
Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Vincent Magloire, Marco de Curtis, Jeffrey Noebels, Gilles Huberfeld, Piotr Suffczynski, Vadym Gnatkovsky, Olga Tyurikova, Dominique Durand, David C. Henshall, Cian McCafferty   +9 more
wiley   +1 more source

Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors [PDF]

, 1989
Kenneth A. Jacobson, Leonidas Kiriasis, Suzanne Barone, Barton J. Bradbury, Udai S. Kammula, Jean Michel Campagne, John W. Daly, John L. Neumeyer, Wolfgang Pfleiderer, Sherrie Secunda   +9 more
openalex   +1 more source

Phosphatidic acid induces cytoskeletal rearrangements through the Src‐FAK‐RhoA/ROCK signaling pathway during decidualization

The FEBS Journal, EarlyView.
Decidualization is the process by which human endometrial stromal cells undergo morphological and functional changes to prepare the uterus for embryo implantation and support pregnancy. Our study identifies the phosphatidic acid‐Src‐FAK‐RhoA/ROCK signaling pathway as a critical regulator of the cytoskeletal alterations required for this transformation.
Hyeon‐Jeong Jun, So Young Lee, Shin‐Young Park, Joong Sub Choi, Mee‐Sup Yoon, Joong‐Soo Han   +5 more
wiley   +1 more source

Investigation of adenosine A1 receptor-mediated β-arrestin 2 recruitment using a split-luciferase assay. [PDF]

Front Pharmacol, 2023
Saecker L, Häberlein H, Franken S.
europepmc   +1 more source

Electrophilic derivatives of purines as irreversible inhibitors of A1 adenosine receptors [PDF]

, 1989
Kenneth A. Jacobson, Suzanne Barone, Udai S. Kammula, Gary L. Stiles   +3 more
openalex   +1 more source

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

The FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John van Swieten, Rodrigo Maillard, Friedrich W. Herberg, Ronit Ilouz   +13 more
wiley   +1 more source

Stimulation of adenosine A1 receptors and bradykinin receptors, which act via different G proteins, synergistically raises inositol 1,4,5-trisphosphate and intracellular free calcium in DDT1 MF-2 smooth muscle cells. [PDF]

, 1992
Pär Gerwins, B.B. Fredholm
openalex   +1 more source

Cerebrospinal fluid and serum biomarkers in idiopathic intracranial hypertension: A systematic review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study aimed to systematically review the literature on soluble biomarkers in adults with idiopathic intracranial hypertension (IIH). Background Idiopathic intracranial hypertension is a multifactorial disorder marked by elevated intracranial pressure without a clear cause.
Marina Romozzi, Fabio Zeoli, Renata Martinelli, Federico Tosto, Antonio Funcis, Giuseppe Garignano, Sabrina Chiloiro, Lucia Di Nardo, Catello Vollono, Alessandro Olivi, Paolo Calabresi, Francesco Signorelli   +11 more
wiley   +1 more source

Chronic ethanol exposure affects adenosinergic mechanism in basal forebrain [abstract] [PDF]

, 2010
Acute ethanol exposure promotes sleep. Chronic ethanol produces insomnia and disrupts sleep. Adenosine promotes sleep by inhibiting wakefulness-promoting neurons in the basal forebrain (BF) via the activation of A1 receptors (A1R).
Engemann, Samuel C., Lodhi, Shafi, Sharma, Rishi   +2 more
core  

Combination Therapy with A1 Receptor Agonist and Vitamin C Improved Working Memory in a Mouse Model of Global Ischemia-Reperfusion

Basic and Clinical Neuroscience, 2013
Introduction: Stroke is one of the most important reasons of death. Hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide.
Mohmmad Zamani, M. Katebi, Mehdi Mehdizadeh, Laya Kafami, Fatemeh Malek, Mansooreh Soleimani   +5 more
doaj