Results 151 to 160 of about 127,904 (323)

Role of S1P‐ and Rho‐kinase signalling in age‐related myogenic tone deficiency in murine resistance arteries

Experimental Physiology, EarlyView.
Abstract Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G‐protein‐coupled receptors and G12/RhoA/Rho kinase are implicated in myogenic tone (MT), and we aimed to clarify their role in pressure sensing and ...
Gry Freja Skovsted, Alex Aupetit, Karl Björling, Kristian Agmund Haanes, Susanne Syberg, Niklas Rye Jørgensen, Blanca I. Aldana, Hirotsugu Tsuchimochi, Mark T. Waddingham, Kristine Freude, James Todd Pearson, Lars Jørn Jensen   +11 more
wiley   +1 more source

Lack of efficacy of a partial adenosine A1 receptor agonist in neuropathic pain models in mice. [PDF]

Purinergic Signal, 2021
Metzner K, Gross T, Balzulat A, Wack G, Lu R, Schmidtko A.   +5 more
europepmc   +1 more source

The agonist of adenosine A1 receptor induced desensitization of delta opioid receptor-mediated Raf-1/MEK/ERK signaling by feedback phosphorylation of Raf-1-Ser289/296/301 [PDF]

, 2022
Chi Xu, Yun Cheng, Yimin Tao, Jing‐Gen Liu   +3 more
openalex   +1 more source

Adenozin által okozott T limfocita diszfunkció szepszisben = The role of adenosine in septic T lymphocyte dysfunction [PDF]

, 2009
A projekt során in vitro Th1/Th2 polarizációs rendszer, Th1 és Th2 irányba differenciáltnak tekinthető hibridóma sejtek, illetve in vivo immunizálással nyert Th1 és Th2 sejtek felhasználásával, valamint A2A receptor specifikus agonista CGS21680, A2A ...
Haskó, György
core  

Glial cells in the heart: Implications for their roles in health and disease

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya, Rimma Dugarova, Shefeeq M. Theparambil   +2 more
wiley   +1 more source

Target screening and optimization of candidate compounds for breast cancer treatment using bioinformatics and computational chemistry approaches

Frontiers in Pharmacology
ObjectivesThis study aimed to identify critical therapeutic targets and design potent antitumor compounds for breast cancer treatment through an integrated bioinformatics and computational chemistry approach.MethodsWe conducted initial screening and ...
Jian Xu, Xue Li, Yiduo Jia, Yiduo Jia
doaj   +1 more source

Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells [PDF]

, 2008
Purinergic signalling is important both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling.
Burnstock, G
core  

Adenosine and acute low oxygen conditions suppress urinary bladder contractility through the activation of adenosine 2B receptors and large‐conductance calcium‐activated potassium channels

The Journal of Physiology, EarlyView.
Abstract figure legend Detrusor smooth muscle surrounding the urinary bladder produces transient pressure events essential for sensing bladder fullness during the filling phase. We investigated the role of adenosine, a ubiquitous signalling molecule, in regulating bladder smooth muscle function.
Gerald M. Herrera, Jason L. Rengo, Grant W. Hennig, Thomas J. Heppner, Alexandria M. Hepp, Maria Sancho, Saul Huerta de la Cruz, Mark T. Nelson, Nicholas R. Klug   +8 more
wiley   +1 more source

Adenosine A1 Receptor Deficiency Aggravates Extracellular Matrix Accumulation in Diabetic Nephropathy through Disturbance of Peritubular Microenvironment. [PDF]

J Diabetes Res, 2021
Tian D, Li J, Zou L, Lin M, Shi X, Hu Y, Lang J, Xu L, Ye W, Li X, Chen L.   +10 more
europepmc   +1 more source

Presynaptic adenosine A1 receptors modulate excitatory transmission in the rat basolateral amygdala

, 2013
Andrew R. Rau, Olusegun J. Ariwodola, Jeff L. Weiner   +2 more
openalex   +1 more source