Elucidation of the molecular mechanisms of biased agonism at the adenosine A1 receptor
, 2021 Samantha M. McNeill
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MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
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Prolonged Adenosine A1 Receptor Activation in Hypoxia and Pial Vessel Disruption Focal Cortical Ischemia Facilitates Clathrin-Mediated AMPA Receptor Endocytosis and Long-Lasting Synaptic Inhibition in Rat Hippocampal CA3-CA1 Synapses: Differential Regulation of GluA2 and GluA1 Subunits by p38 MAPK and JNK [PDF]
, 2014 Zhicheng Chen +5 more
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Protein Science, Volume 35, Issue 2, February 2026.Abstract A bacterial pinoresinol/lariciresinol reductase (PLR) homolog named NrPinZ was obtained from a Novosphingobium rhizosphaerae sp. LY bacterial strain, with NrPinZ being part of its 5‐step biochemical system catabolizing pinoresinol into coniferyl aldehyde and vanillin.
Clyde A. Smith +7 more
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Adenosine A1 receptor antagonist-induced facilitation of postsynaptic AMPA currents in pyramidal neurons of the rat hippocampal CA2 area. [PDF]
Purinergic Signal, 2023 Kawamura M, Sekino Y.
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Differential desensitization of A1 adenosine receptor-mediated inhibition of cardiac myocyte contractility and adenylate cyclase activity. Relation to the regulation of receptor affinity and density. [PDF]
, 1990 Bruce T. Liang, Lucy Donovan
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Astrocyte Regulation of Spinal Circuit Function
Journal of Neurochemistry, Volume 170, Issue 2, February 2026.Spinal cord astrocytes exist as an additional component of the computational framework that governs both sensory perceptions and motor outputs (left). By integrating local synaptic activity together with signals that reflect whole‐body state (e.g., neuromodulators, immune signals, and vascular signals) into defined input states (Sn), astrocytes adapt ...
Mary Kaye Duff +2 more
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Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 2, February 2026.ABSTRACT This study examined whether CYP1A2 (rs762551) genotype modulates the acute ergogenic effects of caffeine on muscular strength and endurance performance in resistance‐trained men and women. Ninety‐four resistance‐trained participants (47 females, 47 males; 39 AA, 44 AC, 11 CC) completed a randomized, triple‐blind, placebo‐controlled, crossover ...
Juan Jesús Montalvo‐Alonso +5 more
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