Results 11 to 20 of about 124,204 (359)

Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure. [PDF]

New England Journal of Medicine, 2010
BACKGROUND Worsening renal function, which is associated with adverse outcomes, often develops in patients with acute heart failure. Experimental and clinical studies suggest that counterregulatory responses mediated by adenosine may be involved.
B. Massie, C. O'connor, M. Metra, P. Ponikowski, J. Teerlink, G. Cotter, B. Weatherley, J. Cleland, M. Givertz, A. Voors, P. Delucca, G. Mansoor, C. Salerno, D. Bloomfield, H. Dittrich   +14 more
semanticscholar   +3 more sources

Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength [PDF]

Journal of Physiology, 2013
•  Neocortical layer 5 pyramidal cell synapses exhibit a developmental reduction in neurotransmitter release probability. Mature synapses are weaker, less reliable and show greater facilitation than immature connections.
Michael I. Kerr, Mark J. Wall, M. J. Richardson   +2 more
semanticscholar   +3 more sources

Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain [PDF]

BMC Biology, 2018
Background G-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities.
Gemma Navarro, Arnau Cordomí, Marc Brugarolas, Estefanía Moreno, David Aguinaga, Laura Pérez-Benito, Sergi Ferre, Antoni Cortés, Vicent Casadó, Josefa Mallol, Enric I. Canela, Carme Lluís, Leonardo Pardo, Peter J. McCormick, Rafael Franco   +14 more
doaj   +4 more sources

Adenosine Inhibits the Excitatory Synaptic Inputs to Basal Forebrain Cholinergic, GABAergic and Parvalbumin Neurons in mice [PDF]

Frontiers in Neurology, 2013
Coffee and tea contain the stimulants caffeine and theophylline. These compounds act as antagonists of adenosine receptors. Adenosine promotes sleep and its extracellular concentration rises in association with prolonged wakefulness, particularly in the ...
Chun eYang, Serena eFranciosi, Serena eFranciosi, Ritchie Edward Brown   +3 more
doaj   +3 more sources

Pharmacological Characterization of FR194921, a New Potent, Selective, and Orally Active Antagonist for Central Adenosine A1 Receptors

Journal of Pharmacological Sciences, 2004
Adenosine A1 receptors in the brain are believed to play an important role in brain functioning. We have discovered a novel adenosine A1 receptor antagonist, FR194921 (2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone),
Takuya Maemoto, Miho Tada, Takuma Mihara, Noriko Ueyama, Hideaki Matsuoka, Katsuya Harada, Takayuki Yamaji, Kiyoharu Shirakawa, Satoru Kuroda, Atsushi Akahane, Akinori Iwashita, Nobuya Matsuoka, Seitaro Mutoh   +12 more
doaj   +3 more sources

Multisite Model of Allosterism for the Adenosine A1 Receptor [PDF]

Journal of Chemical Information and Modeling, 2020
ABSTRACTDespite being a target for about one-third of approved drugs, G protein-coupled receptors (GPCRs) still represent a tremendous reservoir for therapeutic strategies against countless diseases. For example, several cardiovascular and central nervous systems conditions could benefit from clinical agents that activate the adenosine 1 receptor (A1R),
Giuseppe Deganutti, Kerry Barkan, Graham Ladds, Christopher A Reynolds   +3 more
openaire   +3 more sources

Rapid Eye Movement Sleep Deprivation Combined With Fluoxetine Protects Against Depression-Induced Damage and Apoptosis in Rat Hippocampi via A1 Adenosine Receptor

Frontiers in Psychiatry, 2021
Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the detailed molecular mechanisms were not clear.Methods: Rat depression chronic unpredictable stress was constructed, and the body weight of rats was measured.
Xuan Ju, Shengdong Wang, Pan Yan, Chunyan Zhu, Xiwen Hu, Jiezheng Dong, Zhonglin Tan   +6 more
doaj   +1 more source

Immunolocalization of A1 Adenosine Receptors in Mammalian Spermatozoa [PDF]

Journal of Histochemistry & Cytochemistry, 2000
The presence of A1 adenosine receptors (A1AR) in mammalian spermatozoa was previously demonstrated by radiochemical and immunochemical detection. This study was performed to investigate the cellular location of the A1AR to determine whether these receptors were somehow connected with ecto-adenosine deaminase and to evaluate their function in calcium ...
MINELLI, Alba, ALLEGRUCCI, Cinzia, Piomboni P., MANNUCCI, Roberta, Lluis C., Franco R.   +5 more
openaire   +5 more sources

Photoaffinity labeling of A1-adenosine receptors. [PDF]

Journal of Biological Chemistry, 1985
The ligand-binding subunit of the A1-adenosine receptor has been identified by photoaffinity labeling. A photolabile derivative of R-N6-phenylisopropyladenosine, R-2-azido-N6-p-hydroxyphenylisopropyladenosine (R-AHPIA), has been synthesized as a covalent specific ligand for A1-adenosine receptors.
Klotz, Karl-Norbert, Cristalli, G., Grifantini, M., Vittori, S., Lohse, M. J.   +4 more
openaire   +3 more sources

Adenosine receptors in GtoPdb v.2021.2 [PDF]

, 2021
Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Adenosine Receptors [110]) are activated by the endogenous ligand adenosine (potentially inosine also at A3 receptors).
Fredholm, Bertil B., Frenguelli, Bruno G., Hills, Rebecca, IJzerman, Adriaan P., Jacobson, Kenneth A., Klotz, Karl-Norbert, Linden, Joel, Müller, Christa E., Schwabe, Ulrich, Stiles, Gary L.   +9 more
core   +2 more sources