Results 11 to 20 of about 68,176 (222)

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Transient and selective blockade of adenosine A1-receptors by 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) causes sustained epileptiform activity in hippocampal CA3 neurons of guinea pigs [PDF]

, 1989
The effects of endogenously released adenosine on the excitability of hippocampal neurons were studied using the novel and highly selective adenosine A1-receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX).
Alzheimer, Christian, Sutor, Bernd, Ten Bruggencate, Gerrit   +2 more
core   +1 more source

A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]

, 2001
Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Caldwell, Darren, Dale, Nicholas, Frenguelli, Bruno G., Nuritova, Feruza, Pearson, Tim   +4 more
core   +1 more source

A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]

, 2011
The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Atterbury, Alison, Wall, Mark J.
core   +1 more source

Brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A review [PDF]

, 2014
Abbreviations: A2A, adenosine subtype A2A receptor; A1, adenosine subtype A1 receptor; ABC, avidin biotin complex; ABD rat, aortic barodenervated rat; α2 AR, alpha 2 adrenergic receptor; αMNE, alpha methyl norepinephrine; ATP, adenosine triphosphate ...
Abdel-Rahman, Abdel-Rahman, Akbar, Arslan, Barac, Barraco, Barraco, Barraco, Beukers, Bonham, Bousquet, Bousquet, Bousquet, Bousquet, Braga, Bruban, Bruban, Chan, Chan, Chen, Choe, Colombari, de Paula, Dubar, Dunwiddie, Edwards, El-Mas, El-Mas, El-Mas, El-Mas, El-Mas, El-Mas, Ernsberger, Ernsberger, Ernsberger, Ernsberger, Estato, Feldman, Fredholm, Freissmuth, Fresco, Guyenet, Guyenet, Haxhiu, Head, Head, Ibrahim, Iliff, Jastrzebski, Jockers, Kable, Kumagai, Lee, Medvedev, Nassar, Nassar, Nassar, Ongini, Paes-de-Carvalho, Poulsen, Reis, Schulte, Schulte, Scislo, Scislo, Scislo, Scislo, Scislo, Scislo, Scislo, Scislo, Separovic, Separovic, Shen, Spyer, St Lambert, Sun, Szabo, Szabo, Takeda, Tan, Tao, Thomas, Thomas, Tingley, Tolentino-Silva, van Zwieten, Wang, Wang, Wyatt, Yamamoto, Yang, Zhang, Zhang, Zhang   +94 more
core   +2 more sources

A1 adenosine receptor-induced phosphorylation and modulation of transglutaminase 2 activity in H9c2 cells: a role in cell survival [PDF]

, 2016
The regulation of tissue transglutaminase (TG2) activity by the GPCR family is poorly understood. In this study, we investigated the modulation of TG2 activity by the A1 adenosine receptor in cardiomyocyte-like H9c2 cells.H9c2 cells were lysed following ...
Akar, Alan J. Hargreaves, Almami, Basheer, Bennett, Bian, Bollag, Brust, Caccamo, Calmettes, Clare Coveney, Csósz, Dai, David J. Boocock, Davies, Davies, Di-Capua, Dickenson, Dickenson, Dickenson, Dickenson, Dudley, Ethier, Falguni S. Vyas, Filiano, Fretwell, Freund, Germack, Germack, Germack, Germack, Goldsmith, Gundemir, Gundlfinger, Halestrap, Henry, Hescheler, Hoffert, Huang, Imami, John M. Dickenson, Keinan, Kettenbach, Kimes, Lambert, Lee, Lilley, Lorand, Lundby, Matilla, Mhaouty-Kodja, Min, Mishra, Mishra, Mosmann, Nurminskaya, Palacios-Moreno, Perry, Philip L.R. Bonner, Piacentini, Rikova, Robinson, Sabourin, Schaertl, Seshacharyulu, Sheth, Singh, Slaughter, Smith, Stamnaes, Trigwell, Walther, Wang, White, Xu, Yang, Yu, Zhang   +77 more
core   +1 more source

Adenosine induces mesangial cell contraction by an A1-type receptor [PDF]

, 1989
Adenosine induces mesangial cell contraction by an A1-type receptor. Adenosine is known to decrease renal blood flow and glomerular filtration rate. We have tested the hypothesis that adenosine exerts contractile effects on mesangial cells.
Lamas, Santiago, López-Novoa, José M., Olivera, Ana, Rodriguez-Puyol, Diego   +3 more
core   +1 more source

Adenosine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2019
Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Adenosine Receptors [103]) are activated by the endogenous ligand adenosine (potentially inosine also at A3 receptors).
Fredholm, Bertil B., Frenguelli, Bruno G., Hills, Rebecca, IJzerman, Adriaan P., Jacobson, Kenneth A., Klotz, Karl-Norbert, Linden, Joel, Müller, Christa E., Schwabe, Ulrich, Stiles, Gary L.   +9 more
core   +2 more sources

Probe dependence of allosteric enhancers on the binding affinity of adenosine A1‐receptor agonists at rat and human A1‐receptors measured using NanoBRET [PDF]

, 2019
Background and Purpose: Adenosine is a local mediator that regulates a number of physiological and pathological processes via activation of adenosine A1‐receptors.
Cooper, Samantha L., Hill, Stephen J., Jörg, Manuela, Scammells, Peter J., Soave, Mark, Woolard, Jeanette   +5 more
core   +2 more sources

Glutamate-induced depression of EPSP–spike coupling in rat hippocampal CA1 neurons and modulation by adenosine receptors [PDF]

, 2010
The presence of high concentrations of glutamate in the extracellular fluid following brain trauma or ischaemia may contribute substantially to subsequent impairments of neuronal function.
Alici, Andersen, Baratte, Bazhenov, Behan, Benveniste, Bernard, Bernard, Brunedge, Canhão, Carlier, Cash, Clement, Connick, Costenla, Coulter, Cunha, Cunha, Cunha, Cunha, Dahl, Daoudal, Davies, de Mendonça, de Mendonça, de Mendonça, Englund, Ferguson, Fontinha, Forghani, Frenguelli, Frenguelli, Fujii, Fujii, Greiner, Heurteaux, Hoehn, Hülsmann, Jester, Jones, Kitagawa, Klishin, Kukley, Latini, Latini, Lau, Lee, Limbrick, Liu, Lopes, Macgregor, Manzoni, Moore, Nikbakht, Nishizawa, O’Kane, O’Kane, Pedata, Perez-Pinzon, Pugliese, Pugliese, Ribeiro, Schubert, Schurr, Sebastião, Sebastião, Sekino, Sperlagh, Stone, Stone, Szatkowski, Taube, Vizi, Von Lubitz, Wall, Wallis, Wirkner, Wirkner   +77 more
core   +1 more source