Results 11 to 20 of about 31,304 (262)

A1 adenosine receptors mediate hypoglycemia-induced neuronal injury [PDF]

Journal of Molecular Endocrinology, 2004
The cellular mechanisms that lead to neuronal death following glucose deprivation are not known, although it is recognized that hypoglycemia can lead to perturbations in intracellular calcium ([Ca2+]i) levels. Recently, activation of A1 adenosine receptors (A1AR) has been shown to alter [Ca2+]i and promote neuronal death.
CP Turner, Michael R. Blackburn, SA Rivkees   +2 more
openalex   +3 more sources

Frameshift Variant in Novel Adenosine-A1-Receptor Homolog Associated With Bovine Spastic Syndrome/Late-Onset Bovine Spastic Paresis in Holstein Sires. [PDF]

Front Genet, 2020
Krull F, Hirschfeld M, Wemheuer WE, Brenig B.   +3 more
europepmc   +3 more sources

Rapid Eye Movement Sleep Deprivation Combined With Fluoxetine Protects Against Depression-Induced Damage and Apoptosis in Rat Hippocampi via A1 Adenosine Receptor

Frontiers in Psychiatry, 2021
Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the detailed molecular mechanisms were not clear.Methods: Rat depression chronic unpredictable stress was constructed, and the body weight of rats was measured.
Xuan Ju, Shengdong Wang, Pan Yan, Chunyan Zhu, Xiwen Hu, Jiezheng Dong, Zhonglin Tan   +6 more
doaj   +1 more source

A genetic variation in the adenosine A2A receptor gene contributes to variability in oscillatory alpha power in wake and sleep EEG and A1 adenosine receptor availability in the human brain

NeuroImage, 2023
The EEG alpha rhythm (∼ 8–13 Hz) is one of the most salient human brain activity rhythms, modulated by the level of attention and vigilance and related to cerebral energy metabolism.
Naemi L. Tichelman, Anna L. Foerges, Eva-Maria Elmenhorst, Denise Lange, Eva Hennecke, Diego M. Baur, Simone Beer, Tina Kroll, Bernd Neumaier, Andreas Bauer, Hans-Peter Landolt, Daniel Aeschbach, David Elmenhorst   +12 more
doaj   +1 more source

Adenosine A1 Receptor-Mediated Attenuation of Reciprocal Dendro-Dendritic Inhibition in the Mouse Olfactory Bulb

Frontiers in Cellular Neuroscience, 2018
It is well described that A1 adenosine receptors inhibit synaptic transmission at excitatory synapses in the brain, but the effect of adenosine on reciprocal synapses has not been studied so far.
Kristina Schulz, Natalie Rotermund, Katarzyna Grzelka, Jan Benz, Christian Lohr, Daniela Hirnet   +5 more
doaj   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Adenosine A1 receptor antagonist improves intradialytic hypotension [PDF]

Kidney International, 2006
Intradialytic hypotension is a most frequent complication of hemodialysis and may contribute to cardiovascular events and high mortality. There is a hypothesis that an increase in adenosine generation during hemodialysis may cause vasodilation and a decrease in cardiac output, which results in systemic hypotension.
Imai, E., Fujii, M., Kohno, Y., Kageyama, H., Nakahara, K., Hori, M., Tsubakihara, Y.   +6 more
openaire   +2 more sources

Peripheral Antinociception by Carbamazepine in an Inflammatory Mechanical Hyperalgesia Model in the Rat: a New Target for Carbamazepine?

Journal of Pharmacological Sciences, 2006
.: This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100 – 1000 nmol/paw) coadministrated with
Sonja Vučković, Maja Tomić, Radica Stepanović-Petrović, Nenad Ugrešić, Milica Prostran, Bogdan Bošković   +5 more
doaj   +1 more source

Pharmacological Characterization of FR194921, a New Potent, Selective, and Orally Active Antagonist for Central Adenosine A1 Receptors

Journal of Pharmacological Sciences, 2004
Adenosine A1 receptors in the brain are believed to play an important role in brain functioning. We have discovered a novel adenosine A1 receptor antagonist, FR194921 (2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone),
Takuya Maemoto, Miho Tada, Takuma Mihara, Noriko Ueyama, Hideaki Matsuoka, Katsuya Harada, Takayuki Yamaji, Kiyoharu Shirakawa, Satoru Kuroda, Atsushi Akahane, Akinori Iwashita, Nobuya Matsuoka, Seitaro Mutoh   +12 more
doaj   +1 more source

Degranulation of rat omental mast cells by A1 receptor agonists in vitro

Mediators of Inflammation, 1996
The haemodynamic effects of adenosine are thought to result in part from a release of mast cell amines via A3 receptor stimulation. To investigate the nature of the receptors involved in adenosine-induced mast cell degranulation in the rat isolated ...
A. M. Northover, B. J. Northover
doaj   +1 more source