Results 21 to 30 of about 68,176 (222)

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

1030-13 Alterations in Endothelial Cell Adenosine Receptors Mediate Endothelium-Dependent Vasoconstriction in Experimental Vein Grafts [PDF]

, 1995
Adenosine is a potent endogenous vasodilator which mediates its action through A1 and A2 receptor subtypes located on both vascular endothelial and vascular smooth muscle cells (SMC).
Davies, Mark G., Fulton, Gregory J., Hagen, Per-Otto, Ramkumar, Vickrum   +3 more
core   +1 more source

Functional analysis of a human A1 adenosine receptor/green fluorescent protein/Gi1α fusion protein following stable expression in CHO cells [PDF]

, 1999
Fusion proteins between the human A1 adenosine receptor and the pertussis toxin resistant (Cys351Gly) mutant of the G-protein α subunit Gi1α (A1/Gi), and between the human A1 adenosine receptor, the Aequorea victoria green fluorescent protein (GFP) and ...
Bevan, Nicola, Coote, Jim, Drmota, Tomas, Milligan, Graeme, Palmer, Tim, Rees, Stephen, Wise, Alan   +6 more
core   +1 more source

Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization [PDF]

, 2013
Keywords:adenosine;allosterism;receptor;GPCR;dimerization;biased signalling The purine nucleoside adenosine is present in all cells in tightly regulated concentrations. It is released under a variety of physiological and pathophysiological conditions to
Albrecht-Kupper, Alexander, Amoah-Apraku, Aurelio, Aurelio, Avlani, Azzi, Baker, Baker, Bar-Yehuda, Bar-Yehuda, Baraldi, Baraldi, Barbhaiya, Briddon, Bruns, Bruns, Carr, Casadó, Chandrasekera, Chen, Chiavegatta, Chien, Christopoulos, Christopoulos, Chung, Ciruela, Clark, Cohen, Cordeaux, Corriden, Corriden, Cristovao-Ferreira, Dowling, Du, Dubey, Ellis, Fishman, Franco, Fredholm, Gao, Gao, Gao, Gao, Ge, Gessi, Goedeke, Goldman, Graaf, Gracia, Gracia, Griffin, Göblyös, Göblyös, Han, Harrison, Heitman, Hern, Hu, Ilien, Jaakola, Jacobson, Jacobson, Janusz, Kenakin, Kenakin, Keov, Kimatrai-Salvador, Klaft, Klein, Knapp, Kostenis, Kourounakis, Kuszak, Langemeijer, Lazareno, Lee, Lee, Lee, Limbird, Liu, Madi, Mares, Matherne, May, May, May, May, McCrea, Meno, Merighi, Morrison, Muller, Nikolakopoulos, Park, Peeters, Pisterzi, Rasmussen, Romagnoli, Roth, Salvatore, Smith, Sowa, Springael, Street, Suzuki, Swaminath, Tendera, Tinney, Uematsu, Urizar, Valant, Whalen, Williams, Xu   +114 more
core   +2 more sources

Adenosine A1 receptor antagonists in clinical research and development [PDF]

Kidney International, 2010
Selective adenosine A1 receptor antagonists targeting renal microcirculation are novel pharmacologic agents that are currently under development for the treatment of acute heart failure as well as for chronic heart failure. Despite several studies showing improvement of renal function and/or increased diuresis with adenosine A1 antagonists ...
Berthold Hocher, Berthold Hocher
openaire   +3 more sources

Adenosine A1 receptor activation attenuates lung ischemia–reperfusion injury [PDF]

, 2013
ObjectivesIschemia–reperfusion injury contributes significantly to morbidity and mortality in lung transplant patients. Currently, no therapeutic agents are clinically available to prevent ischemia–reperfusion injury, and treatment strategies are limited
Fernandez, Lucas G., Kron, Irving L., LaPar, Damien J., Laubach, Victor E., Sharma, Ashish K.   +4 more
core   +1 more source

Adenosine Signaling in Mast Cells and Allergic Diseases. [PDF]

, 2021
Adenosine is a nucleoside involved in the pathogenesis of allergic diseases. Its effects are mediated through its binding to G protein-coupled receptors: A1, A2a, A2b and A3.
Garcia Garcia, Lucia, Martin, Margarita, Muñoz Cano, Rosa Maria, Olle, Laia, Roca i Ferrer, Jordi   +4 more
core   +1 more source

Adenosinergic regulation of binge-like ethanol drinking and associated locomotor effects in male C57BL/6J mice [PDF]

, 2015
We recently observed that the addition of caffeine (a nonselective adenosine receptor antagonist) to a 20% ethanol solution significantly altered the intoxication profile of male C57BL/6J (B6) mice induced by voluntary binge-like consumption in the ...
Boehm II, Stephen L., Fritz, Brandon M.
core   +1 more source

Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices [PDF]

, 2003
Electrophysiological recordings were used to investigate the effects of ATP analogues on [theta]-burst-induced long-term potentiation (LTP) in rat hippocampal slices.
Almeida, T., Cunha, R. A., Mendonça, A. de, Ribeiro, J. A., Rodrigues, R. J.   +4 more
core   +1 more source

Adenosine A1 receptor antagonist improves intradialytic hypotension [PDF]

Kidney International, 2006
Intradialytic hypotension is a most frequent complication of hemodialysis and may contribute to cardiovascular events and high mortality. There is a hypothesis that an increase in adenosine generation during hemodialysis may cause vasodilation and a decrease in cardiac output, which results in systemic hypotension.
Masatsugu Hori, Enyu Imai, Yoshiharu Tsubakihara, K. Nakahara, H. Kageyama, M. Fujii, Y. Kohno   +6 more
openaire   +3 more sources