Results 31 to 40 of about 31,304 (262)

Involvement of Adenosine A2a Receptor in Intraocular Pressure Decrease Induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-Cyano-1-hexyn-1-yl)adenosine

Journal of Pharmacological Sciences, 2005
The aim of the present study is to clarify the mechanism for the decrease in intraocular pressure by 2-alkynyladenosine derivatives in rabbits. The receptor binding analysis revealed that 2-(1-octyn-1-yl)adenosine (2-O-Ado) and 2-(6-cyano-1-hexyn-1-yl ...
Takashi Konno, Akira Murakami, Takehiro Uchibori, Akihiko Nagai, Kentaro Kogi, Norimichi Nakahata   +5 more
doaj   +1 more source

Altered expression of adenosine A1 receptor in the paraventricular thalamus and its role in the regulation of sleep

陆军军医大学学报
Objective‍　‍To explore the expression profile of adenosine A1 receptor in the paraventricular thalamic nucleus (PVT) in wakefulness/sleep state and its role in regulating sleep.
ZHU Yifeng, WANG Na, HU Junya
doaj   +1 more source

On the basis of sex: male vs. female rat adenosine A1/A2A receptor affinity

BMC Research Notes, 2023
Objective To ensure reproducibility in biomedical research, the biological variable sex must be reported; yet a reason for using male (instead of female) rodents is seldom given.
Helena D. Janse van Rensburg, Gisella Terre’Blanche, Mietha M. Van der Walt   +2 more
doaj   +1 more source

The role of cGMP on adenosine A1 receptor-mediated inhibition of synaptic transmission at the hippocampus

Frontiers in Pharmacology, 2016
Both adenosine A1 receptor and cGMP inhibit synaptic transmission at the hippocampus and recently it was found that A1 receptor increased cGMP levels in hippocampus, but the role of cGMP on A1 receptor-mediated inhibition of synaptic transmission remains
Isa ePinto, André eSerpa, Ana Maria Sebastião, Ana Maria Sebastião, José Francisco Cascalheira, José Francisco Cascalheira   +5 more
doaj   +1 more source

Electroacupuncture-induced neuroprotection against focal cerebral ischemia in the rat is mediated by adenosine A1 receptors

Neural Regeneration Research, 2017
The activation of adenosine A1 receptors is important for protecting against ischemic brain injury and pretreatment with electroacupuncture has been shown to mitigate ischemic brain insult.
Qin-xue Dai, Wu-jun Geng, Xiu-xiu Zhuang, Hong-fa Wang, Yun-chang Mo, He Xin, Jiang-fan Chen, Jun-lu Wang   +7 more
doaj   +1 more source

Anticonvulsant activity of B2, an adenosine analog, on chemical convulsant-induced seizures. [PDF]

PLoS ONE, 2013
Epilepsy is a chronic neurological disorder characterized by recurrent seizures. However, approximately one-third of epilepsy patients still suffer from uncontrolled seizures. Effective treatments for epilepsy are yet to be developed. N (6)-(3-methoxyl-4-
Min Li, Ruixia Kang, Jiangong Shi, Gengtao Liu, Jianjun Zhang   +4 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Central adenosinergic system and its clinical importance

Psychiatry and Clinical Psychopharmacology, 2021
Adenosine is a neuromodulator widely distributed throughout the body. Since it is continuously synthesized, it can be concluded that there is a basal adenosinergic tonus, which has inhibitory effects in general.
Hakan Kayır, I. Tayfun Uzbay
doaj  

5'-Chloro-5'-deoxy-(±)-ENBA, a Potent and Selective Adenosine A1 Receptor Agonist, Alleviates Neuropathic Pain in Mice Through Functional Glial and Microglial Changes without Affecting Motor or Cardiovascular Functions

Molecules, 2012
This study was undertaken in order to investigate the effect of chronic treatment with 5′-chloro-5′-deoxy-(±)-ENBA, a potent and highly selective agonist of human adenosine A1 receptor, on thermal hyperalgesia and mechanical ...
Livio Luongo, Riccardo Petrelli, Luisa Gatta, Catia Giordano, Francesca Guida, Patrizia Vita, Palmarisa Franchetti, Mario Grifantini, Vito de Novellis, Loredana Cappellacci, Sabatino Maione   +10 more
doaj   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source