Results 31 to 40 of about 124,204 (359)

Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization [PDF]

, 2013
Keywords:adenosine;allosterism;receptor;GPCR;dimerization;biased signalling The purine nucleoside adenosine is present in all cells in tightly regulated concentrations. It is released under a variety of physiological and pathophysiological conditions to
Albrecht-Kupper, Alexander, Amoah-Apraku, Aurelio, Aurelio, Avlani, Azzi, Baker, Baker, Bar-Yehuda, Bar-Yehuda, Baraldi, Baraldi, Barbhaiya, Briddon, Bruns, Bruns, Carr, Casadó, Chandrasekera, Chen, Chiavegatta, Chien, Christopoulos, Christopoulos, Chung, Ciruela, Clark, Cohen, Cordeaux, Corriden, Corriden, Cristovao-Ferreira, Dowling, Du, Dubey, Ellis, Fishman, Franco, Fredholm, Gao, Gao, Gao, Gao, Ge, Gessi, Goedeke, Goldman, Graaf, Gracia, Gracia, Griffin, Göblyös, Göblyös, Han, Harrison, Heitman, Hern, Hu, Ilien, Jaakola, Jacobson, Jacobson, Janusz, Kenakin, Kenakin, Keov, Kimatrai-Salvador, Klaft, Klein, Knapp, Kostenis, Kourounakis, Kuszak, Langemeijer, Lazareno, Lee, Lee, Lee, Limbird, Liu, Madi, Mares, Matherne, May, May, May, May, McCrea, Meno, Merighi, Morrison, Muller, Nikolakopoulos, Park, Peeters, Pisterzi, Rasmussen, Romagnoli, Roth, Salvatore, Smith, Sowa, Springael, Street, Suzuki, Swaminath, Tendera, Tinney, Uematsu, Urizar, Valant, Whalen, Williams, Xu   +114 more
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Degranulation of rat omental mast cells by A1 receptor agonists in vitro

Mediators of Inflammation, 1996
The haemodynamic effects of adenosine are thought to result in part from a release of mast cell amines via A3 receptor stimulation. To investigate the nature of the receptors involved in adenosine-induced mast cell degranulation in the rat isolated ...
A. M. Northover, B. J. Northover
doaj   +1 more source

Adenosine A1 Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea

Journal of Neuroscience, 2016
Cisplatin is a commonly used antineoplastic agent that produces ototoxicity that is mediated in part by increasing levels of reactive oxygen species (ROS) via the NOX3 NADPH oxidase pathway in the cochlea.
Tejbeer Kaur, V. Borse, Sandeep Sheth, Kelly Sheehan, Sumana Ghosh, Srinivasan Tupal, S. Jajoo, D. Mukherjea, L. Rybak, V. Ramkumar   +9 more
semanticscholar   +1 more source

Adenosinergic regulation of binge-like ethanol drinking and associated locomotor effects in male C57BL/6J mice [PDF]

, 2015
We recently observed that the addition of caffeine (a nonselective adenosine receptor antagonist) to a 20% ethanol solution significantly altered the intoxication profile of male C57BL/6J (B6) mice induced by voluntary binge-like consumption in the ...
Boehm II, Stephen L., Fritz, Brandon M.
core   +1 more source

Adenosine A1 receptor-mediated protection of mouse hippocampal synaptic transmission against oxygen and/or glucose deprivation: a comparative study.

Journal of Neurophysiology, 2019
Adenosine receptors are widely expressed in the brain and adenosine is a key bioactive substance for neuroprotection. Here, we clarify systematically the role of adenosine A1 receptors during a range of timescales and conditions when a significant amount
M. Kawamura, D. N. Ruskin, S. Masino
semanticscholar   +1 more source

Evidence for the presence of A1 adenosine receptors in the aorta of spontaneously hypertensive rats [PDF]

, 2001
1 Isolated aortic rings (endothelium-intact and -denuded) from spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats were used in this study to examine the vasoactive e ects of various adenosine analogues.
AUCH-SCHWELK, AZEVEDO, BARRETT, BELARDINELLI, BIAGGIONI, BRUNS, BRUNS, CAPARROTTA, CUSHING, EVANS, FAHIM, ILLES, KATUSIC, LAURENT, LEWIS, LI, LINDEN, LOCKETTE, LUSCHER, LUSCHER, MAKUJINA, MUSTAFA, NEELY, PARSONS, PRENTICE, RAMAGOPAL, SCHIEMANN, STOGGALL, TADDEI, TESFAMARIAM, TODOKI, TRIVEDI, VANGALEN   +32 more
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A Role for Adenosine A1 Receptors in GABA and NMDA-Receptor Mediated Modulation of Dopamine Release: Studies Using Fast Cyclic Voltammetry

Sensors, 2008
In the striatum many neurotransmitters including GABA, glutamate, acetylcholine, dopamine, nitric oxide and adenosine interact to regulate synaptic transmission. Dopamine release in the striatum is regulated by a number of pre- and postsynaptic receptors
Carmel O’Neill, John J. O’Connor   +1 more
doaj   +1 more source

Involvement of adenosine A1 receptor in electroacupuncture-mediated inhibition of astrocyte activation during neuropathic pain

Arquivos de Neuro-Psiquiatria, 2018
Neuropathic pain is a chronic pain condition caused by damage or dysfunction of the central or peripheral nervous system. Electroacupuncture (EA) has an antinociceptive effect on neuropathic pain, which is partially due to inhibiting astrocyte activation
Ming-xiao Zhang, Qinxue Dai, Dongdong Liang, Dan Li, Sijia Chen, Shuangdong Chen, Kun-yuan Han, Luping Huang, Junlu Wang   +8 more
semanticscholar   +1 more source

Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices [PDF]

, 2003
Electrophysiological recordings were used to investigate the effects of ATP analogues on [theta]-burst-induced long-term potentiation (LTP) in rat hippocampal slices.
Almeida, T., Cunha, R. A., Mendonça, A. de, Ribeiro, J. A., Rodrigues, R. J.   +4 more
core   +1 more source

Involvement of adenosine signaling pathway in migraine pathophysiology: a systematic review of preclinical studies

The Journal of Headache and Pain, 2022
Background Adenosine is a purinergic signaling molecule with a wide range of physiological functions including anti- and pronociceptive properties. Adenosine receptors are expressed in the trigeminovascular system, and adenosine receptor antagonist ...
Janu Thuraiaiyah, Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Messoud Ashina   +3 more
doaj   +1 more source