Results 41 to 50 of about 127,904 (323)

Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices [PDF]

, 2003
Electrophysiological recordings were used to investigate the effects of ATP analogues on [theta]-burst-induced long-term potentiation (LTP) in rat hippocampal slices.
Almeida, T., Cunha, R. A., Mendonça, A. de, Ribeiro, J. A., Rodrigues, R. J.   +4 more
core   +1 more source

Role of A1 adenosine receptor in cardiovascular diseases: Bridging molecular mechanisms with therapeutic opportunities

Experimental and Molecular Pathology
Adenosine serves as a critical homeostatic regulator, exerting influence over physiological and pathological conditions in the cardiovascular system.
Warisara Parichatikanond, Ratchanee Duangrat, Narawat Nuamnaichati, Supachoke Mangmool   +3 more
doaj   +1 more source

Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine

The Journal of Headache and Pain, 2018
Background Migraine is considered a neurovascular disorder, but its pathophysiological mechanisms are not yet fully understood. Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodilation in several blood vessels ...
Kristian A. Haanes, Alejandro Labastida-Ramírez, Kayi Y. Chan, René de Vries, Brian Shook, Paul Jackson, Jimmy Zhang, Christopher M. Flores, Alexander H. J. Danser, Carlos M. Villalón, Antoinette MaassenVanDenBrink   +10 more
doaj   +1 more source

Adenosinergic regulation of binge-like ethanol drinking and associated locomotor effects in male C57BL/6J mice [PDF]

, 2015
We recently observed that the addition of caffeine (a nonselective adenosine receptor antagonist) to a 20% ethanol solution significantly altered the intoxication profile of male C57BL/6J (B6) mice induced by voluntary binge-like consumption in the ...
Boehm II, Stephen L., Fritz, Brandon M.
core   +1 more source

Pulsed Electromagnetic Fields: A Novel Attractive Therapeutic Opportunity for Neuroprotection After Acute Cerebral Ischemia

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Acute cerebral ischemia is characterized by several pathological processes evolving during time, which contribute to the final tissue damage. Secondary processes, such as prolonged inflammatory response, impaired mitochondrial function and oxidative stress, are responsible for the progression of brain injury to the peri‐infarct area,
Fioravante Capone, Simona Salati, Fabrizio Vincenzi, Micaela Liberti, Giorgio Aicardi, Francesca Apollonio, Katia Varani, Ruggero Cadossi, Vincenzo Di Lazzaro   +8 more
wiley   +1 more source

Involvement of Adenosine A2a Receptor in Intraocular Pressure Decrease Induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-Cyano-1-hexyn-1-yl)adenosine

Journal of Pharmacological Sciences, 2005
The aim of the present study is to clarify the mechanism for the decrease in intraocular pressure by 2-alkynyladenosine derivatives in rabbits. The receptor binding analysis revealed that 2-(1-octyn-1-yl)adenosine (2-O-Ado) and 2-(6-cyano-1-hexyn-1-yl ...
Takashi Konno, Akira Murakami, Takehiro Uchibori, Akihiko Nagai, Kentaro Kogi, Norimichi Nakahata   +5 more
doaj   +1 more source

Adenosine A2A receptors: localization and function [PDF]

, 2015
Adenosine is an endogenous purine nucleoside present in all mammalian tissues, that originates from the breakdown of ATP. By binding to its four receptor subtypes (A1, A2A, A2B, and A3), adenosine regulates several important physiological functions at ...
A Brand, A Gharib, A Kalhan, A Montinaro, A Mori, A Nishi, A Pinna, A Santos-Rodrigues Dos, A Sato, A Tomaru, AA Link, AE King, AK Dixon, AM Mott, AM Sebastiao, AM Sebastiao, AS Awad, B Sperlagh, B Sperlagh, B Sperlagh, BB Fredholm, BB Fredholm, BB Fredholm, BB Fredholm, BB Fredholm, BB Fredholm, BD Hettinger, C Hammarberg, C Ledent, C Quiroz, C Salgado Garcia, CD Bonan, CM Anderson, CN Wilson, CP Sevigny, D Boison, D Boison, D Boison, D Joel, DC Cassada, DJ Brooks, DJ LaPar, DK Glover, DL Rosin, DL Rosin, DN Bowser, E Dare, E Mazzon, F Ciruela, F Ciruela, F Squadrito, FE Parkinson, G Burnstock, G Burnstock, G Burnstock, G Ghimire, G Haskó, G Schulte, G Schulte, GA Higgins, GE Garcia, GG Yegutkin, GM Halliday, GW Sullivan, H Kobayashi, H Zimmermann, HJ Groenewegen, I Feoktistov, J Espinosa, J Fastbom, J Kang, J Snel, J Tchekalarova, JA Ribeiro, JF Chen, JF Chen, JG Dobson Jr, JM Dickenson, JP Headrick, JR Fozard, JS Fink, K Biber, K Fuxe, K Yamada, KD Pierce, L Antonioli, L Antonioli, L Antonioli, L Belardinelli, L Wells, LC Rump, LP Shearman, M Canals, M Fornai, M Katebi, M Kawamura Jr, M Kurokawa, M Kurokawa, M Lazarus, M Matos, M Matos, M Milanese, M Morelli, M Morelli, M Odashima, M O’Neill, M Pouliot, M Reddington, M Schindler, M Storr, MA Ruiz, MA Schwarzschild, MA Souza, MA Trevethick, MC Wittendorp, MD Desrosiers, MD Okusa, MF Jarvis, MJ Bours, MJ Hussey, MJ Wall, MP Abbracchio, MP Abbracchio, MS Hershfield, N Ates, N Cabello, N Levens, N Rebola, N Rebola, N Simola, O Bonneau, O Cauli, O Pascual, P Carriba, P Carriba, P Popoli, P Popoli, P Svenningsson, P Svenningsson, P Svenningsson, P Svenningsson, P Voorn, PA LeWitt, PJ Gebicke-Haerter, R Rahimian, RA Cunha, RA Cunha, RA Cunha, RD Prediger, RH Al-Mashhadi, RJ Rodrigues, S Ferre, S Ferré, S Ferré, S Ferré, S Ferré, S James, S Latini, S Latini, S Revan, SA Baldwin, SA Hunsucker, SA Rivkees, SA Rivkees, SG Khasar, SJ Augood, SJ Brown, SM Duffy, SN Schiffmann, SN Schiffmann, SP Alexander, SW Schoen, T Eckle, T Kadowaki Horita, T Ochiishi, T Othman, TC Bingham, TF Wang, TH Adair, TV Dunwiddie, TV Dunwiddie, V Ralevic, W Hauber, Y Mizuno, Y Pankratov, Y Pankratov, Y Zhong, Z Díaz-Cabiale, Z Justinova, Z Kovacs, Z Selmeczy   +190 more
core   +1 more source

On the basis of sex: male vs. female rat adenosine A1/A2A receptor affinity

BMC Research Notes, 2023
Objective To ensure reproducibility in biomedical research, the biological variable sex must be reported; yet a reason for using male (instead of female) rodents is seldom given.
Helena D. Janse van Rensburg, Gisella Terre’Blanche, Mietha M. Van der Walt   +2 more
doaj   +1 more source

Altered expression of adenosine A1 receptor in the paraventricular thalamus and its role in the regulation of sleep

陆军军医大学学报
Objective‍　‍To explore the expression profile of adenosine A1 receptor in the paraventricular thalamic nucleus (PVT) in wakefulness/sleep state and its role in regulating sleep.
ZHU Yifeng, WANG Na, HU Junya
doaj   +1 more source

The role of cGMP on adenosine A1 receptor-mediated inhibition of synaptic transmission at the hippocampus

Frontiers in Pharmacology, 2016
Both adenosine A1 receptor and cGMP inhibit synaptic transmission at the hippocampus and recently it was found that A1 receptor increased cGMP levels in hippocampus, but the role of cGMP on A1 receptor-mediated inhibition of synaptic transmission remains
Isa ePinto, André eSerpa, Ana Maria Sebastião, Ana Maria Sebastião, José Francisco Cascalheira, José Francisco Cascalheira   +5 more
doaj   +1 more source