Results 41 to 50 of about 124,204 (359)

The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis

Molecules, 2011
The review summarizes data evaluating the role of adenosine receptor signaling in murine hematopoietic functions. The studies carried out utilized either non-selective activation of adenosine receptors induced by elevation of extracellular adenosine or ...
Michal Hofer, Milan Pospisil, Zuzana Hoferova, Lenka Weiterova   +3 more
doaj   +1 more source

The effect of a long-term treatment with cannabidiol-rich hemp extract oil on the adenosinergic system of the zucker diabetic fatty (ZDF) rat atrium

Frontiers in Pharmacology, 2022
Cannabidiol (CBD), the most extensively studied non-intoxicating phytocannabinoid, has been attracting a lot of interest worldwide owing to its numerous beneficial effects.
Gabor Viczjan, Gabor Viczjan, Anna Szilagyi, Barbara Takacs, Ignac Ovari, Reka Szekeres, Vera Tarjanyi, Tamas Erdei, Vanda Teleki, Judit Zsuga, Zoltan Szilvassy, Bela Juhasz, Balazs Varga, Rudolf Gesztelyi   +13 more
doaj   +1 more source

Adenosine signaling in airways: Toward a promising antiasthmatic approach [PDF]

, 2013
Adenosine participates to asthma physiopathology by signaling through more than just one receptor subtype. Defining the role of each receptor is complicated by evidence that often results obtained on rodents do not coincide with human studies, but what ...
CICALA, CARLA, IALENTI, ARMANDO
core   +1 more source

Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine

The Journal of Headache and Pain, 2018
Background Migraine is considered a neurovascular disorder, but its pathophysiological mechanisms are not yet fully understood. Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodilation in several blood vessels ...
Kristian A. Haanes, Alejandro Labastida-Ramírez, Kayi Y. Chan, René de Vries, Brian Shook, Paul Jackson, Jimmy Zhang, Christopher M. Flores, Alexander H. J. Danser, Carlos M. Villalón, Antoinette MaassenVanDenBrink   +10 more
doaj   +1 more source

Agonists for the adenosine A1 receptor with tunable residence time. A Case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines.

Journal of Medicinal Chemistry, 2014
We report the synthesis and evaluation of previously unreported 4-amino-6-aryl-5-cyano-2-thiopyrimidines as selective human adenosine A1 receptor (hA1AR) agonists with tunable binding kinetics, this without affecting their nanomolar affinity for the ...
Julien Louvel, D. Guo, M. Agliardi, Tamara A. M. Mocking, R. Kars, T. P. Pham, Lizi Xia, H. de Vries, J. Brussee, L. Heitman, A. IJzerman   +10 more
semanticscholar   +1 more source

Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]

, 1993
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer, Alzheimer, Alzheimer, Alzheimer, Andreasen, Arai, Ault, Ault, B. Sutor, Bauer, Beavo, Beavo, Ben-Ari, Bruns, Bruns, C. Alzheimer, Chamberlin, Daly, Dragunow, Dragunow, Dunwiddie, Dunwiddie, Dunwiddie, Fredholm, G. Ten Bruggencate, Gerber, Greene, Greene, Haas, Hablitz, Hablitz, Jackisch, Johnston, Linden, Linden, Llinás, Lohse, Madison, Malenka, Meghji, Miles, Moraidis, Nicholson, Pockett, Prestwich, Prince, Scholz, Schubert, Schubert, Smellie, Smellie, Smith, Snyder, Snyder, Sutor, Tanaka, Thompson, Thompson, Van Calker, Williams, Zetterström   +60 more
core   +1 more source

Selective reduction of neurotransmitter release by cAMP-dependent pathways in mouse detrusor [PDF]

, 2022
Parasympathetic nerve-mediated contractions of detrusor smooth muscle are generated by ATP and acetylcholine (ACh) release from efferent nerve terminals. In humans, ACh is responsible for detrusor contractions in normal human bladders, whereas ATP has an
Chakrabarty, Basu, Drake, Marcus J, Fry, Christopher H, Kanai, Anthony J   +3 more
core   +3 more sources

Adenosine A1 receptor antagonists in clinical research and development [PDF]

Kidney International, 2010
Selective adenosine A1 receptor antagonists targeting renal microcirculation are novel pharmacologic agents that are currently under development for the treatment of acute heart failure as well as for chronic heart failure. Despite several studies showing improvement of renal function and/or increased diuresis with adenosine A1 antagonists ...
Berthold Hocher, Berthold Hocher
openaire   +3 more sources

On the basis of sex: male vs. female rat adenosine A1/A2A receptor affinity

BMC Research Notes, 2023
Objective To ensure reproducibility in biomedical research, the biological variable sex must be reported; yet a reason for using male (instead of female) rodents is seldom given.
Helena D. Janse van Rensburg, Gisella Terre’Blanche, Mietha M. Van der Walt   +2 more
doaj   +1 more source

Adenosine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2019
Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Adenosine Receptors [103]) are activated by the endogenous ligand adenosine (potentially inosine also at A3 receptors).
Fredholm, Bertil B., Frenguelli, Bruno G., Hills, Rebecca, IJzerman, Adriaan P., Jacobson, Kenneth A., Klotz, Karl-Norbert, Linden, Joel, Müller, Christa E., Schwabe, Ulrich, Stiles, Gary L.   +9 more
core   +2 more sources