Results 61 to 70 of about 122,823 (298)

5'-Chloro-5'-deoxy-(±)-ENBA, a Potent and Selective Adenosine A1 Receptor Agonist, Alleviates Neuropathic Pain in Mice Through Functional Glial and Microglial Changes without Affecting Motor or Cardiovascular Functions

Molecules, 2012
This study was undertaken in order to investigate the effect of chronic treatment with 5′-chloro-5′-deoxy-(±)-ENBA, a potent and highly selective agonist of human adenosine A1 receptor, on thermal hyperalgesia and mechanical ...
Livio Luongo, Riccardo Petrelli, Luisa Gatta, Catia Giordano, Francesca Guida, Patrizia Vita, Palmarisa Franchetti, Mario Grifantini, Vito de Novellis, Loredana Cappellacci, Sabatino Maione   +10 more
doaj   +1 more source

Anticonvulsant activity of B2, an adenosine analog, on chemical convulsant-induced seizures. [PDF]

PLoS ONE, 2013
Epilepsy is a chronic neurological disorder characterized by recurrent seizures. However, approximately one-third of epilepsy patients still suffer from uncontrolled seizures. Effective treatments for epilepsy are yet to be developed. N (6)-(3-methoxyl-4-
Min Li, Ruixia Kang, Jiangong Shi, Gengtao Liu, Jianjun Zhang   +4 more
doaj   +1 more source

Renal tubule necrosis and apoptosis modulation by A1 adenosine receptor expression [PDF]

, 2007
We have shown that A1 adenosine receptors (A1ARs) are cytoprotective against renal tubular necrosis and apoptosis both in vivo and in vitro. To study the role of A1AR numbers on renal epithelial cell survival, we stably overexpressed the human A1 ...
Emala, C.W., Jan, M., Kim, M., Lee, H.T., Penn, R.B.   +4 more
core   +1 more source

The orphan receptor cDNA RDC7 encodes an A1 adenosine receptor. [PDF]

The EMBO Journal, 1991
The extensive amino acid sequence conservation among G protein-coupled receptors has been exploited to clone new members of this large family by homology screening or by PCR. Out of four such receptor cDNAs we cloned recently, RDC7 corresponds to a relatively abundant transcript in the brain cortex, the thyroid follicular cell and the testis.
Libert, Frédérick, Schiffmann, Serge N., Lefort, Anne, Parmentier, Marc, Gérard, Claude, Dumont, Jacques, Vanderhaeghen, Jean-Jacques, Vassart, Gilbert   +7 more
openaire   +3 more sources

Adenosine Receptor Agonists Modulate Visceral Hyperalgesia in the Rat

Gut and Liver, 2008
Background/Aims: Adenosine is an endogenous modulator of nociception. Its role in visceral nociception, particularly in visceral hyperalgesia, has not been studied.
doaj   +1 more source

Adenosine A1 Receptor-Mediated Activation of Phospholipase C in Cultured Astrocytes Depends on the Level of Receptor Expression

Journal of Neuroscience, 1997
Adenosine A1 receptors induce an inhibition of adenylyl cyclase via G-proteins of the Gi/o family. In addition, simultaneous stimulation of A1 receptors and of receptor-mediated activation of phospholipase C (PLC) results in a synergistic potentiation of
K. Biber, K. Klotz, M. Berger, P. Gebicke-Härter, D. van Calker   +4 more
semanticscholar   +1 more source

Targeting Adenosine A2b Receptor Promotes Penile Rehabilitation of Refractory Erectile Dysfunction

Advanced Science
The mechanisms of adenosine and specific adenosine receptor subtypes in promoting penile rehabilitation remain unclear. Single‐cell RNA sequencing of human corpus cavernosum,  adenosine deaminase (ADA) and adenosine receptors knock‐out mice (ADA−/−, A1−/−
Yang Xiong, Feng Qin, Shanzun Wei, Xingliang Yang, Jun Li, Changjing Wu, Fuxun Zhang, Jiuhong Yuan   +7 more
doaj   +1 more source

Electroacupuncture Pretreatment Prevents Cognitive Impairment Induced by Cerebral Ischemia–Reperfusion via Adenosine A1 Receptors in Rats

Frontiers in Aging Neuroscience, 2021
A previous study has demonstrated that pretreatment with electroacupuncture (EA) induces rapid tolerance to focal cerebral ischemia. In the present study, we investigated whether adenosine receptor 1 (A1 R) is involved in EA pretreatment-induced ...
Yiyi Shi, Qinxue Dai, Binbin Ji, Luping Huang, Xiuxiu Zhuang, Yunchang Mo, Junlu Wang   +6 more
doaj   +1 more source

Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]

, 1993
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer, Alzheimer, Alzheimer, Alzheimer, Andreasen, Arai, Ault, Ault, B. Sutor, Bauer, Beavo, Beavo, Ben-Ari, Bruns, Bruns, C. Alzheimer, Chamberlin, Daly, Dragunow, Dragunow, Dunwiddie, Dunwiddie, Dunwiddie, Fredholm, G. Ten Bruggencate, Gerber, Greene, Greene, Haas, Hablitz, Hablitz, Jackisch, Johnston, Linden, Linden, Llinás, Lohse, Madison, Malenka, Meghji, Miles, Moraidis, Nicholson, Pockett, Prestwich, Prince, Scholz, Schubert, Schubert, Smellie, Smellie, Smith, Snyder, Snyder, Sutor, Tanaka, Thompson, Thompson, Van Calker, Williams, Zetterström   +60 more
core   +1 more source

A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury [PDF]

Journal of Clinical Investigation, 2005
Adenosine is a signaling nucleoside that has been implicated in the regulation of asthma and chronic obstructive pulmonary disease. Adenosine signaling can serve both pro- and anti-inflammatory functions in tissues and cells. In this study we examined the contribution of A(1) adenosine receptor (A(1)AR) signaling to the pulmonary inflammation and ...
Jurgen Schnermann, Michael R. Blackburn, Chun Xiao Sun, Hays W. J. Young, Jose G. Molina, Jonathan B. Volmer   +5 more
openaire   +3 more sources