Results 91 to 100 of about 238,585 (333)

Organ toxicities associated with diet‐induced obesity in rats: Investigation of changes in activities selected enzymes

Biotechnology and Applied Biochemistry, EarlyView.
Abstract Obesity stands out as one of the most significant health problems in the modern world. The prevalence of high‐calorie diets (HCDs) globally exacerbates this condition. Throughout history, plants and plant‐derived food products have been utilized for medicinal purposes, demonstrating their efficacy in the treatment and prevention of various ...
Bedia Bati
wiley   +1 more source

Thermal Analysis of Adenosine Deaminase in the Presence of Sodium N-Dodecyl Sulphate [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1994
The thermal denaturation of adenosine deaminase (ADA) has been investigated in the presence of sodium n-dodecyl sulphate (SDS) over the temperature range of (293-363K) in 2.5 mM phosphate buffer, pH 6.4 by temperature scanning spectroscopy.
Ali Akbar Moosavi Movahedi, Hassan Moghaddamnia, Gholam Hossein Hakimelahi   +2 more
doaj  

Equation-of-motion MLCCSD and CCSD-in-HF oscillator strengths and their application to core excitations [PDF]

arXiv, 2020
We present an implementation of equation-of-motion oscillator strengths for the multilevel CCSD (MLCCSD) model where CCS is used as the lower level method (CCS/CCSD). In this model, the double excitations of the cluster operator are restricted to an active orbital space, whereas the single excitations are unrestricted.
arxiv  

Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency.

Blood, 2016
Adenosine deaminase (ADA) deficiency is a rare, autosomal-recessive systemic metabolic disease characterized by severe combined immunodeficiency (SCID). The treatment of choice for ADA-deficient SCID (ADA-SCID) is hematopoietic stem cell transplant from ...
M. Cicalese, F. Ferrua, L. Castagnaro, R. Pajno, F. Barzaghi, S. Giannelli, F. Dionisio, I. Brigida, Marco Bonopane, Miriam Casiraghi, A. Tabucchi, F. Carlucci, E. Grunebaum, M. Adeli, R. Bredius, J. Puck, P. Stepensky, I. Tezcan, K. Rolfe, E. D. De Boever, R. Reinhardt, J. Appleby, F. Ciceri, M. Roncarolo, A. Aiuti   +24 more
semanticscholar   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

Communication over the network of binary switches regulates the activation of A$_{2A}$ adenosine receptor [PDF]

PLoS Comp. Biol. (2015) 11(2): e1004044, 2014
Dynamics and functions of G-protein coupled receptors (GPCRs) are accurately regulated by the type of ligands that bind to the orthosteric or allosteric binding sites. To glean the structural and dynamical origin of ligand-dependent modulation of GPCR activity, we performed total $\sim$ 5 $\mu$sec molecular dynamics simulations of A$_{2A}$ adenosine ...
arxiv   +1 more source

A thermostable bacterial metallohydrolase that degrades organophosphate plasticizers

ChemBioChem, Accepted Article.
A cyclase‐phosphotriesterase (C‐PTE) from Ruegeria pomeroyi DSS‐3 has recently been identified for its capacity to detoxify several organophosphate compounds. However, several aspects of this enzyme remain unexplored, such as its activity with industrial organophosphates, its molecular structure and its thermostability.
Dawei Ji, Rebecca Frkic, Javad Deylami, Joachim Larsen, Matthew Spence, Colin Jackson   +5 more
wiley   +1 more source

The NAD(P)H:flavin oxidoreductase from Escherichia coli. Evidence for a new mode of binding for reduced pyridine nucleotides [PDF]

The journal of biological chemistry, American Society for Biochemistry and Molecular Biology, 1999, 274, pp.18252-60, 2015
The NAD(P)H:flavin oxidoreductase from Escherichia coli, named Fre, is a monomer of 26.2 kDa that catalyzes the reduction of free flavins using NADPH or NADH as electron donor. The enzyme does not contain any prosthetic group but accommodates both the reduced pyridine nucleotide and the flavin in a ternary complex prior to oxidoreduction.
arxiv   +1 more source

Clinical Evaluation of Potential Interaction Between Bemnifosbuvir and Ruzasvir With an Assessment of Food Effect: Results of a Phase 1 Study in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A combination of nucleotide hepatitis C virus (HCV) nonstructural protein (NS) 5B and 5A inhibitors is a preferred standard of care for treating chronic HCV. Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against HCV NS5B.
Xiao‐Jian Zhou, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Janet Hammond   +7 more
wiley   +1 more source

The genetics of feto-placental development: A study of acid phosphatase locus 1 and adenosine deaminase polymorphisms in a consecutive series of newborn infants

Reproductive Biology and Endocrinology, 2008
Background Acid phosphatase locus 1 and adenosine deaminase locus 1 polymorphisms show cooperative effects on glucose metabolism and immunological functions.
Bergamaschi Antonio, Magrini Andrea, Coppeta Luca, Pietropolli Adalgisa, Gloria-Bottini Fulvia, Bottini Egidio   +5 more
doaj   +1 more source