Results 91 to 100 of about 165,863 (254)

The Role of Adenosine Signaling in Headache: A Review

Brain Sciences, 2017
Migraine is the third most prevalent disease on the planet, yet our understanding of its mechanisms and pathophysiology is surprisingly incomplete. Recent studies have built upon decades of evidence that adenosine, a purine nucleoside that can act as a ...
Nathan T. Fried, Melanie B. Elliott, Michael L. Oshinsky   +2 more
doaj   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis

EMBO Molecular Medicine, 2017
The nucleoside adenosine is a potent regulator of vascular homeostasis, but it remains unclear how expression or function of the adenosine‐metabolizing enzyme adenosine kinase (ADK) and the intracellular adenosine levels influence angiogenesis.
Yiming Xu, Yong Wang, Siyuan Yan, Yaqi Zhou, Qiuhua Yang, Yue Pan, Xianqiu Zeng, Xiaofei An, Zhiping Liu, Lina Wang, Jiean Xu, Yapeng Cao, David J Fulton, Neal L Weintraub, Zsolt Bagi, Md Nasrul Hoda, Xiaoling Wang, Qinkai Li, Mei Hong, Xuejun Jiang, Detlev Boison, Christian Weber, Chaodong Wu, Yuqing Huo   +23 more
doaj   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Oncostatin M upregulates CD73 via the MAPK pathway in keratinocytes to promote an adenosine-dependent anti-inflammatory response in psoriasis

Frontiers in Immunology
IntroductionPsoriasis is a chronic inflammatory skin condition driven by activated epidermal keratinocytes, dermal fibroblasts, and immune cell infiltrates, which causes tissue injury. The ecto-5′-nucleotidase CD73/adenosine pathway plays a critical role
Caterina Giraulo, Caterina Giraulo, Giacomo De Palma, Paola Plaitano, Roberta Esposito, Elva Morretta, Maria Chiara Monti, Christa E. Müller, Carla Cicala, Silvana Morello   +9 more
doaj   +1 more source

Purinergic Signaling in Pulmonary Inflammation

Frontiers in Immunology, 2019
Purine nucleotides and nucleosides are at the center of biologic reactions. In particular, adenosine triphosphate (ATP) is the fundamental energy currency of cellular activity and adenosine has been demonstrated to play essential roles in human ...
Thanh-Thuy T. Le, Nathaniel K. Berg, Matthew T. Harting, Xiangyun Li, Xiangyun Li, Holger K. Eltzschig, Xiaoyi Yuan   +6 more
doaj   +1 more source

Developmental and foliation changes due to dysregulation of adenosine kinase in the cerebellum. [PDF]

Sci Rep, 2023
Gebril HM, Lai T, Fedele DE, Wahba A.
europepmc   +1 more source

UHPLC–MS based metabolomics study of the ErZhi formula on skeletal muscle against osteosarcopenia focusing on energy metabolism

Animal Models and Experimental Medicine, EarlyView.
ErZhi formula (EZF) is composed of Ligustri Lucidi Fructus (LLF) and Ecliptae herba (EH). Ovariectomized (OVX) and sham rats received 12‐week intragastric treatment with EZF, alendronate, and vehicle saline. Gastrocnemius tissues were harvested to systematically evaluate pharmacodynamic changes in skeletal muscle morphology, mitochondrial ...
Yuqing Pang, Ningning Li, Yujie Ding, Shuzhen Hou, Jing Liu, Xiuxue Liu, Erwei Liu, Xiaopeng Chen   +7 more
wiley   +1 more source

Cold Gas Plasma Induces Platelet Activation and Hemostasis in Native and Anticoagulated Human Blood

Advanced NanoBiomed Research, EarlyView.
Cold physical gas plasma induces platelet activation and hemostatic responses in native and anticoagulated human blood. Treatment efficacy depends on plasma parameters, including gas composition, distance, and exposure mode, which govern reactive species delivery and energy transfer.
Sander Bekeschus, Broder Poschkamp, Lea Miebach, Anke Schmidt, Linus Hübner, Julia van der Linde   +5 more
wiley   +1 more source

Ectopic expression of neuronal adenosine kinase, a biomarker in mesial temporal lobe epilepsy without hippocampal sclerosis. [PDF]

Neuropathol Appl Neurobiol, 2023
Guo M, Wang J, Xiong Z, Wang X, Yang Y, Zhang Y, Tang C, Zhang J, Guan Y, Chen F, Yao K, Teng P, Zhou J, Zhai F, Boison D, Luan G, Li T.   +16 more
europepmc   +1 more source