Results 1 to 10 of about 2,608,509 (268)

Molecular basis of ligand binding and receptor activation at the human A₃ adenosine receptor. [PDF]

Nat Commun
Zhang L, Mobbs JI, Bennetts FM, Venugopal H, Nguyen ATN, Christopoulos A, van der Es D, Heitman LH, May LT, Glukhova A, Thal DM.   +10 more
europepmc   +3 more sources

Cancer biology and molecular genetics of A3 adenosine receptor

Oncogene, 2021
A3 adenosine receptor (A3AR) is a cell membrane protein, which has been found to be overexpressed in a large number of cancer types. This receptor plays an important role in cancer by interacting with adenosine.
C. Mazziotta, J. Rotondo, C. Lanzillotti, Giulia Campione, F. Martini, M. Tognon   +5 more
semanticscholar   +1 more source

Adenosine-A2A Receptor Pathway in Cancer Immunotherapy

Frontiers in Immunology, 2022
A2A receptors (A2AR), a typical GPCR with a high affinity for adenosine, was expressed in many immune cells, such as regulatory T cells, cytotoxic T cells, macrophages, etc.
Chang Sun, Bochu Wang, Shilei Hao
semanticscholar   +1 more source

CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy

Nature Communications, 2021
Adenosine is an immunosuppressive factor that limits anti-tumor immunity through the suppression of multiple immune subsets including T cells via activation of the adenosine A2A receptor (A2AR). Using both murine and human chimeric antigen receptor (CAR)
Lauren Giuffrida, K. Sek, M. Henderson, Junyun Lai, Amanda X. Y. Chen, D. Meyran, Kirsten L Todd, Emma V. Petley, Sherly Mardiana, C. Mølck, Gregory D. Stewart, B. Solomon, I. Parish, P. Neeson, S. Harrison, Lev M. Kats, Imran G. House, P. Darcy, P. Beavis   +18 more
semanticscholar   +1 more source

Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome

Nature Communications, 2019
Potentiation of neutrophil extracellular trap (NET) release is one mechanism by which antiphospholipid antibodies (aPL Abs) effect thrombotic events in patients with antiphospholipid syndrome (APS).
R. Ali, Alex A. Gandhi, He Meng, S. Yalavarthi, Andrew P. Vreede, S. Estes, Olivia R. Palmer, P. Bockenstedt, D. Pinsky, J. Greve, J. Diaz, Y. Kanthi, J. Knight   +12 more
semanticscholar   +1 more source

Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development

Frontiers in Cellular Neuroscience, 2019
Adenosine receptors (ARs) function in the body’s response to conditions of pathology and stress associated with a functional imbalance, such as in the supply and demand of energy/oxygen/nutrients.
K. Jacobson, D. Tosh, Shanu Jain, Zhang-Guo Gao   +3 more
semanticscholar   +1 more source

Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance In order for a single breast cancer cell to form a recurrent tumor after therapy or a metastasis at a distant site such as the lung, it must have the properties of a breast cancer stem cell. In this paper, we show that adenosine receptor 2B (
J. Lan, Haiquan Lu, Debangshu Samanta, Shaima Salman, You Lu, G. Semenza   +5 more
semanticscholar   +1 more source

A2A adenosine receptor functional states characterized by 19F-NMR

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance G protein-coupled receptor (GPCR) signaling from the extracellular orthosteric drug binding site across the cell membrane to the intracellular contact sites with G proteins and arrestins is enabled by inherent structural plasticity, which ...
L. Sušac, M. Eddy, T. Didenko, R. Stevens, K. Wüthrich   +4 more
semanticscholar   +1 more source

Targeting Adenosine Receptor Signaling in Cancer Immunotherapy

International Journal of Molecular Sciences, 2018
The immune system plays a major role in the surveillance and control of malignant cells, with the presence of tumor infiltrating lymphocytes (TILs) correlating with better patient prognosis in multiple tumor types. The development of ‘checkpoint blockade’
K. Sek, C. Mølck, Gregory D. Stewart, Lev M. Kats, P. Darcy, P. Beavis   +5 more
semanticscholar   +1 more source

Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression

Frontiers in Pharmacology, 2018
Major depressive disorder is one of the most common and debilitating psychiatric disorders. Some of the motivational symptoms of depression, such anergia (lack of self-reported energy) and fatigue are relatively resistant to traditional treatments such ...
L. Lopez-Cruz, J. Salamone, M. Correa
semanticscholar   +1 more source