Results 11 to 20 of about 2,574,999 (363)
Adenosine Receptors and Wound Healing [PDF]
The Scientific World Journal, 2004 Recent studies have demonstrated that application of topical adenosine A2A receptor agonists promotes more rapid wound closure and clinical studies are currently underway to determine the utility of topical A2A adenosine receptor agonists in the therapy ...
Bruce N. Cronstein
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Annual Review of Physiology, 1992 Our knowledge of A1 and A2ARs has grown dramatically since they were first defined by Burnstock. With the recent purification of the A1AR and the cDNA cloning of the A2AR, an even more rapid expansion of information regarding their structure, function, and regulation should now ensue.
M E, Olah, G L, Stiles
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Adenosine-Related Mechanisms in Non-Adenosine Receptor Drugs
Cells, 2020 Many ligands directly target adenosine receptors (ARs). Here we review the effects of noncanonical AR drugs on adenosinergic signaling. Non-AR mechanisms include raising adenosine levels by inhibiting adenosine transport (e.g., ticagrelor, ethanol, and ...
Kenneth A. Jacobson, Marc L. Reitman
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Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development
Frontiers in Cellular Neuroscience, 2019 Adenosine receptors (ARs) function in the body’s response to conditions of pathology and stress associated with a functional imbalance, such as in the supply and demand of energy/oxygen/nutrients.
K. Jacobson +3 more
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The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis
Molecules, 2011 The review summarizes data evaluating the role of adenosine receptor signaling in murine hematopoietic functions. The studies carried out utilized either non-selective activation of adenosine receptors induced by elevation of extracellular adenosine or ...
Michal Hofer +3 more
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Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance In order for a single breast cancer cell to form a recurrent tumor after therapy or a metastasis at a distant site such as the lung, it must have the properties of a breast cancer stem cell. In this paper, we show that adenosine receptor 2B (
J. Lan +5 more
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Adenosine Receptors and Cancer [PDF]
, 2009 The A(1), A(2A), A(2B) and A(3) G-protein-coupled cell surface adenosine receptors (ARs) are found to be upregulated in various tumor cells. Activation of the receptors by specific ligands, agonists or antagonists, modulates tumor growth via a range of signaling pathways.
Fishman P +6 more
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A2A adenosine receptor functional states characterized by 19F-NMR
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance G protein-coupled receptor (GPCR) signaling from the extracellular orthosteric drug binding site across the cell membrane to the intracellular contact sites with G proteins and arrestins is enabled by inherent structural plasticity, which ...
L. Sušac +4 more
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Discovery of benzothiazolylquinoline conjugates as novel human A3 receptor antagonists: biological evaluations and molecular docking studies [PDF]
Royal Society Open Science, 2018 Adenosine is known as an endogenous purine nucleoside and it modulates a wide variety of physiological responses by interacting with adenosine receptors. Among the four adenosine receptor subtypes, the A3 receptor is of major interest in this study as it
Bidisha Sarkar +3 more
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Adenosine Receptors and Asthma [PDF]
, 2009 The pathophysiological processes underlying respiratory diseases like asthma are complex, resulting in an overwhelming choice of potential targets for the novel treatment of this disease. Despite this complexity, asthmatic subjects are uniquely sensitive to a range of substances like adenosine, thought to act indirectly to evoke changes in respiratory ...
Clive P. Page +5 more
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