Results 11 to 20 of about 2,801,899 (401)

A2B Adenosine Receptor and Cancer [PDF]

International Journal of Molecular Sciences, 2019
There are four subtypes of adenosine receptors (ARs), named A1, A2A, A2B and A3, all of which are G protein-coupled receptors (GPCRs). Locally produced adenosine is a suppressant in anti-tumor immune surveillance. The A2BAR, coupled to both Gαs and Gαi G proteins, is one of the several GPCRs that are expressed in a significantly higher level in certain
Zhan-Guo Gao, Kenneth A. Jacobson
openaire   +3 more sources

Mast cell adenosine receptors function: a focus on the A3 adenosine receptor and inflammation

Frontiers in Immunology, 2012
Adenosine is a metabolite, which has long been implicated in a variety of inflammatory processes. Inhaled adenosine provokes bronchoconstriction in asthmatics or chronic obstructive pulmonary disease (COPD) patients, but not in non-asthmatics. This hyper
Noam eRudich, Katya eRavid, Ronit eSagi-Eisenberg   +2 more
doaj   +2 more sources

Cancer biology and molecular genetics of A3 adenosine receptor

Oncogene, 2021
A3 adenosine receptor (A3AR) is a cell membrane protein, which has been found to be overexpressed in a large number of cancer types. This receptor plays an important role in cancer by interacting with adenosine.
C. Mazziotta, J. Rotondo, C. Lanzillotti, Giulia Campione, F. Martini, M. Tognon   +5 more
semanticscholar   +1 more source

Adenosine-A2A Receptor Pathway in Cancer Immunotherapy

Frontiers in Immunology, 2022
A2A receptors (A2AR), a typical GPCR with a high affinity for adenosine, was expressed in many immune cells, such as regulatory T cells, cytotoxic T cells, macrophages, etc.
Chang Sun, Bochu Wang, Shilei Hao
semanticscholar   +1 more source

CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy

Nature Communications, 2021
Adenosine is an immunosuppressive factor that limits anti-tumor immunity through the suppression of multiple immune subsets including T cells via activation of the adenosine A2A receptor (A2AR). Using both murine and human chimeric antigen receptor (CAR)
Lauren Giuffrida, K. Sek, M. Henderson, Junyun Lai, Amanda X. Y. Chen, D. Meyran, Kirsten L Todd, Emma V. Petley, Sherly Mardiana, C. Mølck, Gregory D. Stewart, B. Solomon, I. Parish, P. Neeson, S. Harrison, Lev M. Kats, Imran G. House, P. Darcy, P. Beavis   +18 more
semanticscholar   +1 more source

Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome

Nature Communications, 2019
Potentiation of neutrophil extracellular trap (NET) release is one mechanism by which antiphospholipid antibodies (aPL Abs) effect thrombotic events in patients with antiphospholipid syndrome (APS).
R. Ali, Alex A. Gandhi, He Meng, S. Yalavarthi, Andrew P. Vreede, S. Estes, Olivia R. Palmer, P. Bockenstedt, D. Pinsky, J. Greve, J. Diaz, Y. Kanthi, J. Knight   +12 more
semanticscholar   +1 more source

Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength [PDF]

, 2013
During the first postnatal month glutamatergic synapses between layer 5 pyramidal cells in the rodent neocortex switch from an immature state exhibiting high probability of neurotransmitter release, large unitary amplitude and synaptic depression to a ...
Dunwiddie TV, Magnus J. E. Richardson, Mark J. Wall, Michael I. Kerr   +3 more
core   +1 more source

Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development

Frontiers in Cellular Neuroscience, 2019
Adenosine receptors (ARs) function in the body’s response to conditions of pathology and stress associated with a functional imbalance, such as in the supply and demand of energy/oxygen/nutrients.
K. Jacobson, D. Tosh, Shanu Jain, Zhang-Guo Gao   +3 more
semanticscholar   +1 more source

The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis

Molecules, 2011
The review summarizes data evaluating the role of adenosine receptor signaling in murine hematopoietic functions. The studies carried out utilized either non-selective activation of adenosine receptors induced by elevation of extracellular adenosine or ...
Michal Hofer, Milan Pospisil, Zuzana Hoferova, Lenka Weiterova   +3 more
doaj   +1 more source

Involvement of Adenosine A2a Receptor in Intraocular Pressure Decrease Induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-Cyano-1-hexyn-1-yl)adenosine

Journal of Pharmacological Sciences, 2005
The aim of the present study is to clarify the mechanism for the decrease in intraocular pressure by 2-alkynyladenosine derivatives in rabbits. The receptor binding analysis revealed that 2-(1-octyn-1-yl)adenosine (2-O-Ado) and 2-(6-cyano-1-hexyn-1-yl ...
Takashi Konno, Akira Murakami, Takehiro Uchibori, Akihiko Nagai, Kentaro Kogi, Norimichi Nakahata   +5 more
doaj   +1 more source