Results 21 to 30 of about 2,574,999 (363)
Sensors, 2008 In the striatum many neurotransmitters including GABA, glutamate, acetylcholine, dopamine, nitric oxide and adenosine interact to regulate synaptic transmission. Dopamine release in the striatum is regulated by a number of pre- and postsynaptic receptors
Carmel O’Neill +1 more
doaj +1 more source
Molecules, 2022 In the present study, we investigated the molecular mechanisms of adenosine for its hair growth promoting effect. Adenosine stimulated the Wnt/β-catenin pathway by modulating the activity of Gsk3β in cultured human dermal papilla cells. It also activated
Jaeyoon Kim +4 more
doaj +1 more source
Targeting Adenosine Receptor Signaling in Cancer Immunotherapy
International Journal of Molecular Sciences, 2018 The immune system plays a major role in the surveillance and control of malignant cells, with the presence of tumor infiltrating lymphocytes (TILs) correlating with better patient prognosis in multiple tumor types. The development of ‘checkpoint blockade’
K. Sek +5 more
semanticscholar +1 more source
Adenosine receptors and cancer
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011 Adenosine is a ubiquitous signaling molecule whose physiological functions are mediated by its interaction with four G-protein-coupled receptor subtypes, termed A(1), A(2A), A(2B) and A(3). As a result of increased metabolic rates, this nucleoside is released from a variety of cells throughout the body in concentrations that can have a profound impact ...
GESSI, Stefania +4 more
openaire +4 more sources
Adenosine receptors and asthma [PDF]
British Journal of Pharmacology, 2008 The accumulation of evidence implicating a role for adenosine in the pathogenesis of asthma has led to investigations into all adenosine receptor subtypes as potential therapeutic targets for the treatment of asthma. Selective A1receptor antagonists are currently in preclinical development since adenosine has been shown experimentally to mediate ...
Brown, R A, Spina, D, Page, C P
openaire +4 more sources
مجله دانشکده پزشکی اصفهان, 2018 Background: A2B adenosine receptor (A2BAR) is member of the family of seven transmembrane G protein coupled receptor that are activated in high concentration of extracellular adenosine that occur in certain pathophysiological conditions.
Abdol-Vahab Shafiee +1 more
doaj +1 more source
Frontiers in Pharmacology, 2018 Major depressive disorder is one of the most common and debilitating psychiatric disorders. Some of the motivational symptoms of depression, such anergia (lack of self-reported energy) and fatigue are relatively resistant to traditional treatments such ...
L. Lopez-Cruz, J. Salamone, M. Correa
semanticscholar +1 more source
Special Issue: Adenosine Receptors [PDF]
Molecules, 2017 Nearly 90 years ago, Drury and Szent-Györgyi revealed that adenosine produced profound hypotension and bradycardia, and it affected kidney function in mammals [1]. [...]
Francisco Ciruela, Eddy Sotelo
openaire +4 more sources
Adenosine Receptor-Mediated Cardioprotection—Current Limitations and Future Directions
Frontiers in Pharmacology, 2018 Since the seminal reports of adenosine receptor-mediated cardioprotection in the early 1990s, there have been a multitude of such reports in various species and preparations.
Robert D. Lasley
doaj +1 more source
Egyptian Rheumatology and Rehabilitation, 2022 Background Adenosine signaling is now an accepted explanation for the therapeutic mechanism of Methotrexate (MTX) in rheumatoid arthritis (RA). Adenosine receptors categorized into four subclasses: adenosine A1 receptor (ADORA1), adenosine 2a receptor ...
Nivine Fathi Darwish +5 more
doaj +1 more source