Results 21 to 30 of about 2,712,589 (407)

Adenosine Receptors and Cancer [PDF]

, 2009
The A(1), A(2A), A(2B) and A(3) G-protein-coupled cell surface adenosine receptors (ARs) are found to be upregulated in various tumor cells. Activation of the receptors by specific ligands, agonists or antagonists, modulates tumor growth via a range of signaling pathways.
Fishman P, Bar Yehuda S, Synowitz M, Powell JD, Klotz KN, GESSI, Stefania, BOREA, Pier Andrea   +6 more
openaire   +3 more sources

Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance In order for a single breast cancer cell to form a recurrent tumor after therapy or a metastasis at a distant site such as the lung, it must have the properties of a breast cancer stem cell. In this paper, we show that adenosine receptor 2B (
J. Lan, Haiquan Lu, Debangshu Samanta, Shaima Salman, You Lu, G. Semenza   +5 more
semanticscholar   +1 more source

Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength [PDF]

, 2013
During the first postnatal month glutamatergic synapses between layer 5 pyramidal cells in the rodent neocortex switch from an immature state exhibiting high probability of neurotransmitter release, large unitary amplitude and synaptic depression to a ...
Dunwiddie TV, Magnus J. E. Richardson, Mark J. Wall, Michael I. Kerr   +3 more
core   +1 more source

Tissue-derived proinflammatory effect of adenosine A2B receptor in lung ischemia–reperfusion injury [PDF]

, 2010
ObjectiveIschemia–reperfusion injury after lung transplantation remains a major source of morbidity and mortality. Adenosine receptors have been implicated in both pro- and anti-inflammatory roles in ischemia–reperfusion injury.
Anvari, Farshad, Fernandez, Lucas G., Hranjec, Tjasa, Kron, Irving L., Laubach, Victor E., Ravid, Katya, Sharma, Ashish K.   +6 more
core   +1 more source

A Role for Adenosine A1 Receptors in GABA and NMDA-Receptor Mediated Modulation of Dopamine Release: Studies Using Fast Cyclic Voltammetry

Sensors, 2008
In the striatum many neurotransmitters including GABA, glutamate, acetylcholine, dopamine, nitric oxide and adenosine interact to regulate synaptic transmission. Dopamine release in the striatum is regulated by a number of pre- and postsynaptic receptors
Carmel O’Neill, John J. O’Connor   +1 more
doaj   +1 more source

Discovery of benzothiazolylquinoline conjugates as novel human A3 receptor antagonists: biological evaluations and molecular docking studies [PDF]

Royal Society Open Science, 2018
Adenosine is known as an endogenous purine nucleoside and it modulates a wide variety of physiological responses by interacting with adenosine receptors. Among the four adenosine receptor subtypes, the A3 receptor is of major interest in this study as it
Bidisha Sarkar, Santanu Maiti, Gajanan Raosaheb Jadhav, Priyankar Paira   +3 more
doaj   +1 more source

Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of Gsk3β Activity in Cultured Human Dermal Papilla Cells

Molecules, 2022
In the present study, we investigated the molecular mechanisms of adenosine for its hair growth promoting effect. Adenosine stimulated the Wnt/β-catenin pathway by modulating the activity of Gsk3β in cultured human dermal papilla cells. It also activated
Jaeyoon Kim, Jae Young Shin, Yun-Ho Choi, Nae Gyu Kang, Sanghwa Lee   +4 more
doaj   +1 more source

Targeting Adenosine Receptor Signaling in Cancer Immunotherapy

International Journal of Molecular Sciences, 2018
The immune system plays a major role in the surveillance and control of malignant cells, with the presence of tumor infiltrating lymphocytes (TILs) correlating with better patient prognosis in multiple tumor types. The development of ‘checkpoint blockade’
K. Sek, C. Mølck, Gregory D. Stewart, Lev M. Kats, P. Darcy, P. Beavis   +5 more
semanticscholar   +1 more source

Adenosine receptors and cancer

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011
Adenosine is a ubiquitous signaling molecule whose physiological functions are mediated by its interaction with four G-protein-coupled receptor subtypes, termed A(1), A(2A), A(2B) and A(3). As a result of increased metabolic rates, this nucleoside is released from a variety of cells throughout the body in concentrations that can have a profound impact ...
GESSI, Stefania, MERIGHI, Stefania, SACCHETTO, Valeria, SIMIONI, Carolina, BOREA, Pier Andrea   +4 more
openaire   +4 more sources

Adenosine Receptors and Asthma [PDF]

, 2009
The pathophysiological processes underlying respiratory diseases like asthma are complex, resulting in an overwhelming choice of potential targets for the novel treatment of this disease. Despite this complexity, asthmatic subjects are uniquely sensitive to a range of substances like adenosine, thought to act indirectly to evoke changes in respiratory ...
Clive P. Page, Ahmed Nadeem, Domenico Spina, Rachel C. Brown, Constance N. Wilson, S. Jamal Mustafa   +5 more
openaire   +3 more sources