Results 31 to 40 of about 370,006 (352)

Low expression of CD39 and CD73 genes in centenarians compared with octogenarians

Immunity & Ageing, 2017
Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells.
Almudena Crooke, Juan Martínez-Henández, Joaquín Martínez-López, Alfonso Cruz-Jentoft, Fernando Huete-Toral, Jesús Pintor   +5 more
doaj   +1 more source

Adenosine Receptors and Wound Healing

The Scientific World Journal, 2004
Recent studies have demonstrated that application of topical adenosine A2A receptor agonists promotes more rapid wound closure and clinical studies are currently underway to determine the utility of topical A2A adenosine receptor agonists in the therapy ...
Bruce N. Cronstein
doaj   +1 more source

Reversing adenosine-mediated immunosuppression in triple-negative breast cancer by synergistic chemo-immunotherapy via stimuli-responsive nanomedicinesResearch in context

EBioMedicine
Summary: Background: Chemotherapy remains the first-line treatment for triple-negative breast cancer (TNBC). Anthracycline chemotherapeutics, such as epirubicin (EPI), not only kill tumor cells but also induce immunogenic cell death (ICD).
Xinying Cheng, Hao Cai, Xue Li, Yuxin Zhang, Siying Li, Yunkun Li, Na Hu, Su Lui, Jing Jing, Qiyong Gong, Kui Luo   +10 more
doaj   +1 more source

Evidence for the presence of A1 adenosine receptors in the aorta of spontaneously hypertensive rats [PDF]

, 2001
1 Isolated aortic rings (endothelium-intact and -denuded) from spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats were used in this study to examine the vasoactive e ects of various adenosine analogues.
AUCH-SCHWELK, AZEVEDO, BARRETT, BELARDINELLI, BIAGGIONI, BRUNS, BRUNS, CAPARROTTA, CUSHING, EVANS, FAHIM, ILLES, KATUSIC, LAURENT, LEWIS, LI, LINDEN, LOCKETTE, LUSCHER, LUSCHER, MAKUJINA, MUSTAFA, NEELY, PARSONS, PRENTICE, RAMAGOPAL, SCHIEMANN, STOGGALL, TADDEI, TESFAMARIAM, TODOKI, TRIVEDI, VANGALEN   +32 more
core   +2 more sources

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Adenosine Stimulates Glutamate Release From Astrocytes via A2a Adenosine Receptors

Journal of Pharmacological Sciences, 2004
Adenosine enhanced intracellular Ca2+ concentrations in astrocytes via A2a adenosine receptors involving protein kinase A (PKA) activation. The Ca2+ rise is inhibited by brefeldin A, an inhibitor of vesicular transport; but not by neomycin and U73122 ...
Tomoyuki Nishizaki
doaj   +1 more source

Intracellular ATP concentration contributes to the cytotoxic and cytoprotective effects of adenosine. [PDF]

PLoS ONE, 2013
Extracellular adenosine (ADE) interacts with cells by two pathways: by activating cell surface receptors at nanomolar/micromolar concentrations; and by interfering with the homeostasis of the intracellular nucleotide pool at millimolar concentrations ...
Shujue Li, Xiaofen Li, Haiping Guo, Shouting Liu, Hongbiao Huang, Ningning Liu, Changshan Yang, Ping Tang, Jinbao Liu   +8 more
doaj   +1 more source

Adenosine-Metabolizing Enzymes, Adenosine Kinase and Adenosine Deaminase, in Cancer

Biomolecules, 2022
The immunosuppressive effect of adenosine in the microenvironment of a tumor is well established. Presently, researchers are developing approaches in immune therapy that target inhibition of adenosine or its signaling such as CD39 or CD73 inhibiting ...
Galina Zhulai, Eugenia Oleinik, Mikhail Shibaev, Kirill Ignatev   +3 more
doaj   +1 more source

Glutamate-induced depression of EPSP–spike coupling in rat hippocampal CA1 neurons and modulation by adenosine receptors [PDF]

, 2010
The presence of high concentrations of glutamate in the extracellular fluid following brain trauma or ischaemia may contribute substantially to subsequent impairments of neuronal function.
Alici, Andersen, Baratte, Bazhenov, Behan, Benveniste, Bernard, Bernard, Brunedge, Canhão, Carlier, Cash, Clement, Connick, Costenla, Coulter, Cunha, Cunha, Cunha, Cunha, Dahl, Daoudal, Davies, de Mendonça, de Mendonça, de Mendonça, Englund, Ferguson, Fontinha, Forghani, Frenguelli, Frenguelli, Fujii, Fujii, Greiner, Heurteaux, Hoehn, Hülsmann, Jester, Jones, Kitagawa, Klishin, Kukley, Latini, Latini, Lau, Lee, Limbrick, Liu, Lopes, Macgregor, Manzoni, Moore, Nikbakht, Nishizawa, O’Kane, O’Kane, Pedata, Perez-Pinzon, Pugliese, Pugliese, Ribeiro, Schubert, Schurr, Sebastião, Sebastião, Sekino, Sperlagh, Stone, Stone, Szatkowski, Taube, Vizi, Von Lubitz, Wall, Wallis, Wirkner, Wirkner   +77 more
core   +1 more source

The Role of Adenosine Signaling in Headache: A Review

Brain Sciences, 2017
Migraine is the third most prevalent disease on the planet, yet our understanding of its mechanisms and pathophysiology is surprisingly incomplete. Recent studies have built upon decades of evidence that adenosine, a purine nucleoside that can act as a ...
Nathan T. Fried, Melanie B. Elliott, Michael L. Oshinsky   +2 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source