Results 31 to 40 of about 2,801,899 (401)
Adenosine signaling in airways: Toward a promising antiasthmatic approach [PDF]
, 2013 Adenosine participates to asthma physiopathology by signaling through more than just one receptor subtype. Defining the role of each receptor is complicated by evidence that often results obtained on rodents do not coincide with human studies, but what ...
CICALA, CARLA, IALENTI, ARMANDO
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A2A adenosine receptor functional states characterized by 19F-NMR
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance G protein-coupled receptor (GPCR) signaling from the extracellular orthosteric drug binding site across the cell membrane to the intracellular contact sites with G proteins and arrestins is enabled by inherent structural plasticity, which ...
L. Sušac +4 more
semanticscholar +1 more source
Sensors, 2008 In the striatum many neurotransmitters including GABA, glutamate, acetylcholine, dopamine, nitric oxide and adenosine interact to regulate synaptic transmission. Dopamine release in the striatum is regulated by a number of pre- and postsynaptic receptors
Carmel O’Neill +1 more
doaj +1 more source
Evidence for coordinated induction and repression of ecto-5'-nucleotidase (CD73) and the A2a adenosine receptor in a human B cell line [PDF]
, 2003 In the human B cell line P493-6 two mitogenic signals, the EpsteinBarr virus nuclear antigen 2 (EBNA2) and myc, can be independently regulated by means of an estrogen receptor fusion construct or an inducible expression vector, respectively.
Burgemeister R. +6 more
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Targeting Adenosine Receptor Signaling in Cancer Immunotherapy
International Journal of Molecular Sciences, 2018 The immune system plays a major role in the surveillance and control of malignant cells, with the presence of tumor infiltrating lymphocytes (TILs) correlating with better patient prognosis in multiple tumor types. The development of ‘checkpoint blockade’
K. Sek +5 more
semanticscholar +1 more source
مجله دانشکده پزشکی اصفهان, 2018 Background: A2B adenosine receptor (A2BAR) is member of the family of seven transmembrane G protein coupled receptor that are activated in high concentration of extracellular adenosine that occur in certain pathophysiological conditions.
Abdol-Vahab Shafiee +1 more
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Egyptian Rheumatology and Rehabilitation, 2022 Background Adenosine signaling is now an accepted explanation for the therapeutic mechanism of Methotrexate (MTX) in rheumatoid arthritis (RA). Adenosine receptors categorized into four subclasses: adenosine A1 receptor (ADORA1), adenosine 2a receptor ...
Nivine Fathi Darwish +5 more
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Frontiers in Pharmacology, 2018 Major depressive disorder is one of the most common and debilitating psychiatric disorders. Some of the motivational symptoms of depression, such anergia (lack of self-reported energy) and fatigue are relatively resistant to traditional treatments such ...
L. Lopez-Cruz, J. Salamone, M. Correa
semanticscholar +1 more source
Transient and selective blockade of adenosine A1-receptors by 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) causes sustained epileptiform activity in hippocampal CA3 neurons of guinea pigs [PDF]
, 1989 The effects of endogenously released adenosine on the excitability of hippocampal neurons were studied using the novel and highly selective adenosine A1-receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX).
Alzheimer, Christian +2 more
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Adenosine Receptor-Mediated Cardioprotection—Current Limitations and Future Directions
Frontiers in Pharmacology, 2018 Since the seminal reports of adenosine receptor-mediated cardioprotection in the early 1990s, there have been a multitude of such reports in various species and preparations.
Robert D. Lasley
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