Results 31 to 40 of about 2,712,589 (407)

Adenosine receptors and asthma [PDF]

British Journal of Pharmacology, 2008
The accumulation of evidence implicating a role for adenosine in the pathogenesis of asthma has led to investigations into all adenosine receptor subtypes as potential therapeutic targets for the treatment of asthma. Selective A1receptor antagonists are currently in preclinical development since adenosine has been shown experimentally to mediate ...
Brown, R A, Spina, D, Page, C P
openaire   +4 more sources

Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]

, 1993
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer, Alzheimer, Alzheimer, Alzheimer, Andreasen, Arai, Ault, Ault, B. Sutor, Bauer, Beavo, Beavo, Ben-Ari, Bruns, Bruns, C. Alzheimer, Chamberlin, Daly, Dragunow, Dragunow, Dunwiddie, Dunwiddie, Dunwiddie, Fredholm, G. Ten Bruggencate, Gerber, Greene, Greene, Haas, Hablitz, Hablitz, Jackisch, Johnston, Linden, Linden, Llinás, Lohse, Madison, Malenka, Meghji, Miles, Moraidis, Nicholson, Pockett, Prestwich, Prince, Scholz, Schubert, Schubert, Smellie, Smellie, Smith, Snyder, Snyder, Sutor, Tanaka, Thompson, Thompson, Van Calker, Williams, Zetterström   +60 more
core   +1 more source

Evaluation of the Effects A2B Adenosine Receptor-Agonist (BAY 60–6583) in Induction of Apoptosis in ACHN Renal Cancer Cell Line

مجله دانشکده پزشکی اصفهان, 2018
Background: A2B adenosine receptor (A2BAR) is member of the family of seven transmembrane G protein coupled receptor that are activated in high concentration of extracellular adenosine that occur in certain pathophysiological conditions.
Abdol-Vahab Shafiee, Mohammadreza Sharifi   +1 more
doaj   +1 more source

Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression

Frontiers in Pharmacology, 2018
Major depressive disorder is one of the most common and debilitating psychiatric disorders. Some of the motivational symptoms of depression, such anergia (lack of self-reported energy) and fatigue are relatively resistant to traditional treatments such ...
L. Lopez-Cruz, J. Salamone, M. Correa
semanticscholar   +1 more source

Special Issue: Adenosine Receptors [PDF]

Molecules, 2017
Nearly 90 years ago, Drury and Szent-Györgyi revealed that adenosine produced profound hypotension and bradycardia, and it affected kidney function in mammals [1]. [...]
Francisco Ciruela, Eddy Sotelo
openaire   +4 more sources

Activation of adenosine A2A receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts : implications for neuromodulation [PDF]

, 2010
Copyright © 2010 the authorsBrain-derived neurotrophic factor (BDNF) signaling is critical for neuronal development and transmission. Recruitment of TrkB receptors to lipid rafts has been hown to be necessary for the activation of specific signaling ...
Assaife-Lopes, Natália, Chao, Moses V., Pereira, Daniela B., Ribeiro, Joaquim A., Sebastião, Ana M, Sousa, Vasco C.   +5 more
core   +1 more source

A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]

, 2001
Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Caldwell, Darren, Dale, Nicholas, Frenguelli, Bruno G., Nuritova, Feruza, Pearson, Tim   +4 more
core   +1 more source

The implication of adenosine receptor expression in prediction of methotrexate clinical response in Egyptian rheumatoid arthritis patients

Egyptian Rheumatology and Rehabilitation, 2022
Background Adenosine signaling is now an accepted explanation for the therapeutic mechanism of Methotrexate (MTX) in rheumatoid arthritis (RA). Adenosine receptors categorized into four subclasses: adenosine A1 receptor (ADORA1), adenosine 2a receptor ...
Nivine Fathi Darwish, Samar Abd Alhamed Tabra, Nivin Naeem Baiomy, Heba A. Mahmoud, Reham A. Mariah, Shymaa Ahmed Hablas   +5 more
doaj   +1 more source

Allosteric modulation of adenosine receptors [PDF]

Purinergic Signalling, 2008
Allosteric ligands for G protein-coupled receptors (GPCRs) may alter receptor conformations induced by an orthosteric ligand. These modulators can thus fine-tune classical pharmacological responses. In this review we will describe efforts to synthesize and characterize allosteric modulators for one particular GPCR subfamily, the adenosine receptors ...
Anikó Göblyös, Ad P. IJzerman
openaire   +5 more sources

Adenosine Receptor-Mediated Cardioprotection—Current Limitations and Future Directions

Frontiers in Pharmacology, 2018
Since the seminal reports of adenosine receptor-mediated cardioprotection in the early 1990s, there have been a multitude of such reports in various species and preparations.
Robert D. Lasley
doaj   +1 more source