Results 41 to 50 of about 2,712,589 (407)

Tissue-nonspecific alkaline phosphatase promotes axonal growth of hippocampal neurons [PDF]

, 2011
Axonal growth is essential for establishing neuronal circuits during brain development and for regenerative processes in the adult brain. Unfortunately, the extracellular signals controlling axonal growth are poorly understood.
Díaz-Hernández, Juan Ignacio, Díaz-Hernández, Miguel, Díez-Zaera, Maria, Hernández-Álvarez, Elena, Miras Portugal, María Teresa, Zimmermann, H.   +5 more
core   +2 more sources

Adenosine Receptors and the Kidney [PDF]

, 2009
The autacoid, adenosine, is present in the normoxic kidney and generated in the cytosol as well as at extracellular sites. The rate of adenosine formation is enhanced when the rate of ATP hydrolysis prevails over the rate of ATP synthesis during increased tubular transport work or during oxygen deficiency.
Volker Vallon, Hartmut Osswald
openaire   +2 more sources

Internalization and desensitization of adenosine receptors [PDF]

Purinergic Signalling, 2007
Until now, more than 800 distinct G protein-coupled receptors (GPCRs) have been identified in the human genome. The four subtypes of the adenosine receptor (A(1), A(2A), A(2B) and A(3) receptor) belong to this large family of GPCRs that represent the most widely targeted pharmacological protein class. Since adenosine receptors are widespread throughout
Klaasse, E.C., IJzerman, A.P., Grip, W.J. de, Beukers, M.W.   +3 more
openaire   +4 more sources

A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]

, 2011
The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Atterbury, Alison, Wall, Mark J.
core   +1 more source

Brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A review [PDF]

, 2014
Abbreviations: A2A, adenosine subtype A2A receptor; A1, adenosine subtype A1 receptor; ABC, avidin biotin complex; ABD rat, aortic barodenervated rat; α2 AR, alpha 2 adrenergic receptor; αMNE, alpha methyl norepinephrine; ATP, adenosine triphosphate ...
Abdel-Rahman, Abdel-Rahman, Akbar, Arslan, Barac, Barraco, Barraco, Barraco, Beukers, Bonham, Bousquet, Bousquet, Bousquet, Bousquet, Braga, Bruban, Bruban, Chan, Chan, Chen, Choe, Colombari, de Paula, Dubar, Dunwiddie, Edwards, El-Mas, El-Mas, El-Mas, El-Mas, El-Mas, El-Mas, Ernsberger, Ernsberger, Ernsberger, Ernsberger, Estato, Feldman, Fredholm, Freissmuth, Fresco, Guyenet, Guyenet, Haxhiu, Head, Head, Ibrahim, Iliff, Jastrzebski, Jockers, Kable, Kumagai, Lee, Medvedev, Nassar, Nassar, Nassar, Ongini, Paes-de-Carvalho, Poulsen, Reis, Schulte, Schulte, Scislo, Scislo, Scislo, Scislo, Scislo, Scislo, Scislo, Scislo, Separovic, Separovic, Shen, Spyer, St Lambert, Sun, Szabo, Szabo, Takeda, Tan, Tao, Thomas, Thomas, Tingley, Tolentino-Silva, van Zwieten, Wang, Wang, Wyatt, Yamamoto, Yang, Zhang, Zhang, Zhang   +94 more
core   +2 more sources

Adenosine A2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer.

Cancer Discovery, 2019
Adenosine mediates immunosuppression within the tumor microenvironment through triggering adenosine 2A receptors (A2AR) on immune cells. To determine whether this pathway could be targeted as an immunotherapy, we performed a phase 1 clinical trial with a
L. Fong, A. Hotson, J. Powderly, M. Sznol, R. Heist, T. Choueiri, S. George, B. Hughes, M. Hellmann, D. Shepard, B. Rini, S. Kummar, A. Weise, Matthew J. Riese, B. Markman, L. Emens, D. Mahadevan, J. Luke, G. Laport, J. Brody, L. Hernandez-Aya, P. Bonomi, J. Goldman, L. Berim, D. Renouf, R. Goodwin, B. Munneke, P. Ho, J. Hsieh, I. McCaffery, L. Kwei, S. Willingham, Richard A. Miller   +32 more
semanticscholar   +1 more source

Fluorescent ligands for adenosine receptors [PDF]

Bioorganic & Medicinal Chemistry Letters, 2013
Interest is increasing in developing fluorescent ligands for characterization of adenosine receptors (ARs), which hold a promise of usefulness in the drug discovery process. The size of a strategically labeled AR ligand can be greatly increased after the attachment of a fluorophore. The choice of dye moiety (e.g.
Eszter Kozma, P. Suresh Jayasekara, Lucia Squarcialupi, Silvia Paoletta, Stefano Moro, FEDERICO, STEPHANIE, SPALLUTO, GIAMPIERO, Kenneth A. Jacobson   +7 more
openaire   +5 more sources

Adenosine signaling in airways: Toward a promising antiasthmatic approach [PDF]

, 2013
Adenosine participates to asthma physiopathology by signaling through more than just one receptor subtype. Defining the role of each receptor is complicated by evidence that often results obtained on rodents do not coincide with human studies, but what ...
CICALA, CARLA, IALENTI, ARMANDO
core   +1 more source

The molecular effects of Asperuloside against thermogenesis and anti-inflammatory process through multiple recent obesity pathways: An anti-obesity drug discovery by in-silico analysis

Journal of King Saud University: Science, 2023
Objectives: Adenosine receptor signaling and suppressing potential pathways such as the aryl hydrocarbon receptor (AHR) and takeda G-protein-coupled receptor-5(TGR5) have been identified as potential targets for enhancing metabolic health.
Aftab Ahmad, Asif Husain, Mohammed F. Abuzinadah, Anwar A. Alghamdi, Varish Ahmad, Rasheed A. Shaik, Basma G. Eid   +6 more
doaj  

Low expression of CD39 and CD73 genes in centenarians compared with octogenarians

Immunity & Ageing, 2017
Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells.
Almudena Crooke, Juan Martínez-Henández, Joaquín Martínez-López, Alfonso Cruz-Jentoft, Fernando Huete-Toral, Jesús Pintor   +5 more
doaj   +1 more source