Results 41 to 50 of about 2,801,899 (401)

Glutamate-induced depression of EPSP–spike coupling in rat hippocampal CA1 neurons and modulation by adenosine receptors [PDF]

, 2010
The presence of high concentrations of glutamate in the extracellular fluid following brain trauma or ischaemia may contribute substantially to subsequent impairments of neuronal function.
Alici, Andersen, Baratte, Bazhenov, Behan, Benveniste, Bernard, Bernard, Brunedge, Canhão, Carlier, Cash, Clement, Connick, Costenla, Coulter, Cunha, Cunha, Cunha, Cunha, Dahl, Daoudal, Davies, de Mendonça, de Mendonça, de Mendonça, Englund, Ferguson, Fontinha, Forghani, Frenguelli, Frenguelli, Fujii, Fujii, Greiner, Heurteaux, Hoehn, Hülsmann, Jester, Jones, Kitagawa, Klishin, Kukley, Latini, Latini, Lau, Lee, Limbrick, Liu, Lopes, Macgregor, Manzoni, Moore, Nikbakht, Nishizawa, O’Kane, O’Kane, Pedata, Perez-Pinzon, Pugliese, Pugliese, Ribeiro, Schubert, Schurr, Sebastião, Sebastião, Sekino, Sperlagh, Stone, Stone, Szatkowski, Taube, Vizi, Von Lubitz, Wall, Wallis, Wirkner, Wirkner   +77 more
core   +1 more source

New paradigms in adenosine receptor pharmacology: allostery, oligomerization and biased agonism

British Journal of Pharmacology, 2018
Adenosine receptors are a family of GPCRs containing four subtypes (A1, A2A, A2B and A3 receptors), all of which bind the ubiquitous nucleoside adenosine.
E. A. Vecchio, Joanne Baltos, A. T. Nguyen, A. Christopoulos, P. White, L. May   +5 more
semanticscholar   +1 more source

Low expression of CD39 and CD73 genes in centenarians compared with octogenarians

Immunity & Ageing, 2017
Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells.
Almudena Crooke, Juan Martínez-Henández, Joaquín Martínez-López, Alfonso Cruz-Jentoft, Fernando Huete-Toral, Jesús Pintor   +5 more
doaj   +1 more source

Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury [PDF]

, 2005
Acute respiratory distress syndrome (ARDS) usually requires symptomatic supportive therapy by intubation and mechanical ventilation with the supplemental use of high oxygen concentrations.
, Agorreta, Ahmad, Akio Ohta, Alexander Chouker, Andonegui, Apasov, Bell, Bosco, Brown, Carvalho, Charles Caldwell, Chen, Chris Haslett, Decking, Derevianko, Dharmana, Dmitry Lukashev, Edward Jackson, Eltzschig, Estenssoro, Freeman, Gardinali, Goss, Guida, Hasko, Headley, Iris Bittmann, Ishida, Khoa, Kotani, Lachmann, Lahat, LeClaire, Leeper-Woodford, Linden, Lukashev, Madjdpour, Malbouisson, Manfred Thiel, Martin, Matuschak, Michail V Sitkovsky, Nader-Djalal, Ndengele, Ohta, Patrick Smith, Pietersma, Pinhu, Pizov, Regel, Simms, Sitkovsky, Sue, Sullivan, Tateda, Thiel, Thiel, Tremblay, Tsan, Uchiba, Ward, Wieland   +62 more
core   +5 more sources

Adenosine A2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer.

Cancer Discovery, 2019
Adenosine mediates immunosuppression within the tumor microenvironment through triggering adenosine 2A receptors (A2AR) on immune cells. To determine whether this pathway could be targeted as an immunotherapy, we performed a phase 1 clinical trial with a
L. Fong, A. Hotson, J. Powderly, M. Sznol, R. Heist, T. Choueiri, S. George, B. Hughes, M. Hellmann, D. Shepard, B. Rini, S. Kummar, A. Weise, Matthew J. Riese, B. Markman, L. Emens, D. Mahadevan, J. Luke, G. Laport, J. Brody, L. Hernandez-Aya, P. Bonomi, J. Goldman, L. Berim, D. Renouf, R. Goodwin, Brian Munneke, P. Ho, J. Hsieh, I. McCaffery, L. Kwei, S. Willingham, Richard A. Miller   +32 more
semanticscholar   +1 more source

Next steps for clinical translation of adenosine pathway inhibition in cancer immunotherapy

Journal for ImmunoTherapy of Cancer, 2022
Increasing evidence supports targeting the adenosine pathway in immuno-oncology with several clinical programs directed at adenosine A2 receptor (A2AR, A2BR), CD73 and CD39 in development.
Ryan C Augustin, R. Leone, A. Naing, L. Fong, R. Bao, J. Luke   +5 more
semanticscholar   +1 more source

Adenosine Receptors and Wound Healing

The Scientific World Journal, 2004
Recent studies have demonstrated that application of topical adenosine A2A receptor agonists promotes more rapid wound closure and clinical studies are currently underway to determine the utility of topical A2A adenosine receptor agonists in the therapy ...
Bruce N. Cronstein
doaj   +1 more source

Reversing adenosine-mediated immunosuppression in triple-negative breast cancer by synergistic chemo-immunotherapy via stimuli-responsive nanomedicinesResearch in context

EBioMedicine
Summary: Background: Chemotherapy remains the first-line treatment for triple-negative breast cancer (TNBC). Anthracycline chemotherapeutics, such as epirubicin (EPI), not only kill tumor cells but also induce immunogenic cell death (ICD).
Xinying Cheng, Hao Cai, Xue Li, Yuxin Zhang, Siying Li, Yunkun Li, Na Hu, Su Lui, Jing Jing, Qiyong Gong, Kui Luo   +10 more
doaj   +1 more source

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Adenosine Stimulates Glutamate Release From Astrocytes via A2a Adenosine Receptors

Journal of Pharmacological Sciences, 2004
Adenosine enhanced intracellular Ca2+ concentrations in astrocytes via A2a adenosine receptors involving protein kinase A (PKA) activation. The Ca2+ rise is inhibited by brefeldin A, an inhibitor of vesicular transport; but not by neomycin and U73122 ...
Tomoyuki Nishizaki
doaj   +1 more source

Intracellular ATP concentration contributes to the cytotoxic and cytoprotective effects of adenosine. [PDF]

PLoS ONE, 2013
Extracellular adenosine (ADE) interacts with cells by two pathways: by activating cell surface receptors at nanomolar/micromolar concentrations; and by interfering with the homeostasis of the intracellular nucleotide pool at millimolar concentrations ...
Shujue Li, Xiaofen Li, Haiping Guo, Shouting Liu, Hongbiao Huang, Ningning Liu, Changshan Yang, Ping Tang, Jinbao Liu   +8 more
doaj   +1 more source