Results 231 to 240 of about 271,223 (294)

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Clinical and Physiological Predictors of Acetylcholine‐Induced Coronary Spasm in ANOCA/INOCA Patients: A Retrospective Cohort Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background A substantial proportion of patients with angina and/or ischemia are found to have non‐obstructive coronary arteries (ANOCA/INOCA). Their symptoms can sometimes be explained by coronary microvascular dysfunction and/or vasospasm. Selecting patients for acetylcholine testing remains challenging, and the procedure is not trivial in ...
Jeremie Buri, Aurelia Zimmerli, Thabo Mahendiran, Adil Salihu, Victor Weerts, Olivier Muller, David Meier, Stephane Fournier   +7 more
wiley   +1 more source

Engineering Bisubstrates to Target m6Am RNA Methyltransferases: Synthesis and Computational Studies

Chemistry – A European Journal, EarlyView.
Use of the convertible nucleoside approach to synthesize m6Am RNA methyltransferase bisubstrates. This methodology allows for the introduction of modifications on the SAM analog moiety and the RNA substrate part, including the introduction of a cap analog by click chemistry.
Yoann Colas, Laurent Le Corre, Mélanie Ethève‐Quelquejeu, Emmanuelle Braud   +3 more
wiley   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Aging changes the expression of adenosine receptors, insulin-like growth factor 1 (IGF1), and hypoxia-inducible factor 1α (HIF1α) in hypothalamic astrocyte cultures. [PDF]

Aging Brain
Santos CL, Bobermin LD, Quincozes-Santos A.   +2 more
europepmc   +1 more source

Discontinuing Long‐Term Denosumab in Treating Fragile Bone: Why, for Whom, and How?

Clinical Pharmacology &Therapeutics, EarlyView.
Discontinuation of denosumab (Dmab) may be necessary due to adverse events or an unfavorable long‐term risk–benefit profile. However, accumulating evidence demonstrates pronounced rebound phenomena after withdrawal, most notably a marked increase in multiple vertebral fractures, and, in some reports, elevated mortality.
Ko‐Hsiu Lu, Renn‐Chia Lin, Ing‐Lin Chang, Shau‐Huai Fu, Meng‐Ying Tsai, Shun‐Fa Yang   +5 more
wiley   +1 more source

High atmospheric pressure rescues plant growth under humidity stress: A model for climate‐resilient deep underground agriculture

Deep Underground Science and Engineering, EarlyView.
High atmospheric pressure (120 kPa) in deep underground counteracts humidity‐induced physiological stress in plants, stabilizing water balance and enhancing antioxidative defenses. This synergy boosts biomass despite elevated humidity, demonstrating sustainable deep underground agriculture potential under climate uncertainty.
Yuxin He, Linglu Xu, Xiao Tan, Wenhua Zhuang, Naiwen Li, Chao Liu, Bo Tan   +6 more
wiley   +1 more source

The role of purinergic signalling in the musculoskeletal system [PDF]

Abbracchio, Agrawal, Alvarenga, Armstrong, Banachewicz, Berenbaum, Biswas, Biver, Bonewald, Bowler, Bowler, Bowler, Brandao-Burch, Brown, Buckley, Buckley, Buckley, Bulman, Burnstock, Burnstock, Burnstock, Burnstock, Buscher, Buvinic, Campo, Carroll, Caswell, Caswell, Chenu, Cheung, Choi, Chowdhury, Costa, Costessi, Croucher, Deli, Dixon, Evans, Ferrari, Fleisch, Fleisch, Fodor, Gartland, Gartland, Gartland, Gartland, Gartland, Genetos, Genetos, Gharibi, Gharibi, Graff, Graff, Grol, Hajjawi, Hayton, Hazama, He, Hecht, Hessle, Hiken, Hoebertz, Hoebertz, Hoebertz, Hollopeter, Hsu, Hung, Huo, Husted, Ihara, Isabel R. Orriss, Jande, Janssens, Janssens, Johnson, Jones, Jorgensen, Jorgensen, Jorgensen, Kanabe, Kaplan, Kaplan, Kara, Kara, Katz, Katz, Ke, Keresztes, Knight, Kono, Koolpe, Koolpe, Korcok, Korcok, Kringelbach, Kudirka, Kumagai, Kumagai, Lee, Leong, Leong, Lerner, Lerner, Li, Li, Liu, Mackenzie, Martinello, Masin, Mediero, Mediero, Meyer, Millward-Sadler, Morrison, Mortensen, Naemsch, Naemsch, Nakamura, Nicke, Nishii, Noronha-Matos, Noronha-Matos, Ohlendorff, Orriss, Orriss, Orriss, Orriss, Orriss, Orriss, Orriss, Orriss, Orriss, Panupinthu, Panupinthu, Pellegatti, Penolazzi, Pines, Ralevic, Reimer, Riddle, Romanello, Romanello, Rosenthal, Rumney, Ryan, Ryten, Schoenberg, Sciancalepore, Shimegi, Sistare, Su, Suzuki, Syberg, Syberg, Takedachi, Tesch, Thompson, Tu, Varani, Varani, Vincenzi, Voss, Wang, Wang, Wang, Weidema, Weidema, Wesselius, Wesselius, Wesselius, Wiebe, Wildman, You, Yu, Yu, Zimmermann, Zippel   +176 more
core   +1 more source

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

Developmental Dynamics, EarlyView.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore, Anjali Balakrishnan, Yacine Touahri, Dawn Zinyk, Humna Noman, Satoshi Okawa, Jeff Biernaskie, Carol Schuurmans   +7 more
wiley   +1 more source