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Adenosine and ATP Receptors in the Brain
Current Topics in Medicinal Chemistry, 2011There is a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the brain on both neurones and glial cells. Adenosine receptors play a major role in presynaptic neuromodulation, while P2X receptors are involved in fast synaptic transmission and synaptic plasticity. P2Y receptors largely mediate presynaptic activities.
Burnstock, Geoffrey +2 more
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2007
Adenosine and ATP, via P1 and P2 receptors respectively, can modulate pain transmission under physiological, inflammatory, and neuropathic pain conditions. Such influences reflect peripheral and central actions and effects on neurons as well as other cell types.
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Adenosine and ATP, via P1 and P2 receptors respectively, can modulate pain transmission under physiological, inflammatory, and neuropathic pain conditions. Such influences reflect peripheral and central actions and effects on neurons as well as other cell types.
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An adenosine receptor for olfaction
Science Signaling, 2017Extracellular processing of ATP in the fish olfactory epithelium produces adenosine that is perceived by olfactory neurons.
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Adenosine Receptors in Health and Disease
2011The adenosine receptors A(1), A(2A), A(2B), and A(3) are important and ubiquitous mediators of cellular signaling, which play vital roles in protecting tissues and organs from damage. In particular, adenosine triggers tissue protection and repair by different receptor-mediated mechanisms, including an increase of oxygen supply/demand ratio ...
GESSI, Stefania +3 more
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Adenosine Receptors on Human Lymphocytes
1986Evidence is accumulating that adenosine functions as an important immunoregulatory autacoid (1,2). Adenosine inhibits the mitotic response of human lymphocytes (3,4), lymphocyte-mediated cytolysis (5), superoxide anion generation by neutrophils (6), platelet aggregation (7) and mediator release from human basophils (8-10). The nucleoside has been shown
MARONE, GIANNI +3 more
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Adenosine, adenosine receptors and glaucoma: An updated overview
Biochimica et Biophysica Acta (BBA) - General Subjects, 2013Glaucoma, a leading cause of blindness worldwide, is an optic neuropathy commonly associated with elevated intraocular pressure (IOP). The major goals of glaucoma treatments are to lower IOP and protect retinal ganglion cells. It has been revealed recently that adenosine and adenosine receptors (ARs) have important roles in IOP modulation and ...
Yisheng, Zhong +3 more
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[Adenosine and adenosine receptors in the kidney].
Nihon rinsho. Japanese journal of clinical medicine, 1993In the kidney, adenosine plays important regulatory roles, including renal blood flow, glomerular filtration rate, renin secretion, tubuloglomerular feedback, tubular reabsorption of sodium and water, sympathetic neurotransmitter release, and erythropoietin secretion.
S, Umemura +6 more
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Lymphocytes and adenosine receptors
Pharmacological Research, 1992DIANZANI, Chiara +3 more
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