Results 51 to 60 of about 35,275 (163)

CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement

Nature Communications, 2019
Human adenoviruses (HAd) cause respiratory, gastrointestinal and ocular infections. Here, the authors provide insights into the early stages of adenovirus infection by determining the cryo-EM structure of the trimeric HAd type 3 fibre knob bound to its ...
Emilie Vassal-Stermann, Gregory Effantin, Chloe Zubieta, Wim Burmeister, Frédéric Iseni, Hongjie Wang, André Lieber, Guy Schoehn, Pascal Fender   +8 more
doaj   +1 more source

Human Adenoviruses, Cholesterol Trafficking, and NF-?B Signaling

Journal of Immunological Sciences, 2018
The interplay between viruses and host factors regulating inflammatory or cytotoxic responses directed against infected cells is well documented. Viruses have evolved a wide array of mechanisms that strike a balance between the elimination of virus and immune-mediated tissue injury by antiviral immune responses.
Nicholas L, Cianciola, Cathleen R, Carlin   +1 more
openaire   +2 more sources

Expanding the Scope of Adenoviral Vectors by Utilizing Novel Tools for Recombination and Vector Rescue

Viruses
Recombinant adenoviruses are widely used in clinical and laboratory applications. Despite the wide variety of available sero- and genotypes, only a fraction is utilized in vivo.
Julian Fischer, Ariana Fedotova, Clara Bühler, Laura Darriba, Sabrina Schreiner, Zsolt Ruzsics   +5 more
doaj   +1 more source

Adenovirus-Mediated Expression of Dengue Virus 2 Envelope Ferritin Nanoparticles Induced Virus-Specific Immune Responses in BALB/c Mice

Microbiology Research
This study provides a preliminary background for the development of a viral vector vaccine for the dengue virus using genetic material encoded by dengue envelope ferritin nanoparticles.
M.S.B.W.T.M. Nipuna Sudaraka Tennakoon, Ji-Hoon Ryu, Yong-Sam Jung, Yingjuan Qian, Hyun-Jin Shin   +4 more
doaj   +1 more source

Role of homologous recombination/recombineering on human adenovirus genome engineering: Not the only but the most competent solution

Engineering Microbiology
Adenoviruses typically cause mild illnesses, but severe diseases may occur primarily in immunodeficient individuals, particularly children. Recently, adenoviruses have garnered significant interest as a versatile tool in gene therapy, tumor treatment ...
Lisa-Marie Dawson, Montaha Alshawabkeh, Katrin Schröer, Fatima Arakrak, Anja Ehrhardt, Wenli Zhang   +5 more
doaj   +1 more source

Systemic Infection with Enteric Adenovirus in Immunocompetent Child with Haemophilus influenzae Disease

Emerging Infectious Diseases, 2009
Nino Khetsuriani, Suxiang Tong, Xiaoyan Lu, Shannon Reed, Dean D. Erdman, Angela P. Campbell, Krongkaew Supawat, Sahas Liamsuwan, Narayanan Jothikumar, Sonja J. Olsen   +9 more
doaj   +1 more source

Rapid detection of human adenovirus by multiple cross displacement amplification combined with nanoparticle-based biosensor platform

Sensors and Actuators Reports
Human adenoviruses (HAdV), particularly serotypes 3 and 7 (HAdV-3 and HAdV-7), are significant respiratory pathogens that contribute to high morbidity rates and severe pneumonia in infants and children.
Linglong Wan, Xiaolan Huang, Jin Fu, Fei Xiao, Nan Jia, Yu Zhang, Min Chen, Xiong Zhu, Shijun Li, Juan Zhou, Yi Wang   +10 more
doaj   +1 more source

Human adenoviruses in children with gastroenteritis: a systematic review and meta-analysis

BMC Infectious Diseases
Purpose Human adenoviruses (HAdVs) have always been suggested as one of the main causes of gastroenteritis in children. However, no comprehensive report on the global epidemiology of these viruses in pediatric gastroenteritis is available.
Pegah Khales, Mohammad Hossein Razizadeh, Saied Ghorbani, Afagh Moattari, Jamal Sarvari, Hassan Saadati, Shirin Sayyahfar, Zahra Salavatiha, Morteza Haghighi Hasanabad, Vahdat Poortahmasebi, Ahmad Tavakoli   +10 more
doaj   +1 more source

Metagenomic and transcriptomic investigation of pediatric acute liver failure cases reveals a common pathway predominated by monocytes

mBio
In 2022, a cluster of severe childhood hepatitis was detected primarily in Europe and North America, leading to a global alert by the World Health Organization.
Ruben H. de Kleine, Ellen C. Carbo, Willem S. Lexmond, Xuewei W. Zhou, Alicia de Kroon, Hailiang Mei, Sander T. H. Bontemps, Rick Hennevelt, Lilli Gard, Igor A. Sidorov, Stefan A. Boers, Marius C. van den Heuvel, Emilie P. Buddingh, Aloys C. M. Kroes, Vincent E. de Meijer, Elisabeth H. Schölvinck, Karin J. von Eije, Simon P. Jochems, Jutte J. C. de Vries   +18 more
doaj   +1 more source

Whole genome-based surveillance for human adenovirus-related diseases in Kobe City, Japan, 2018–2022

BMC Research Notes
Background Human adenoviruses (HAdVs) cause various diseases, and they frequently undergo recombination. As adenoviruses are susceptible to recombination, whole-genome sequencing and analysis are essential approaches to understanding viral properties. In
Yoshihiko Tanimoto, Minori Ohyama, Erika Ito, Kyoko Akiyoshi, Yuka Onishi, Ai Mori, Ryohei Nomoto   +6 more
doaj   +1 more source