Results 161 to 170 of about 23,918 (199)

Prokaryotic adenylate cyclase toxin stimulates anterior pituitary cells in culture

American Journal of Physiology-Endocrinology and Metabolism, 1986
Bordetella pertussis synthesizes a variety of virulence factors including a calmodulin-dependent adenylate cyclase (AC) toxin. Treatment of anterior pituitary cells with this AC toxin resulted in an increase in cellular cAMP levels that was associated with accelerated exocytosis of growth hormone (GH), prolactin, adrenocorticotropic hormone (ACTH), and
M J, Cronin, W S, Evans, A D, Rogol, A A, Weiss, M O, Thorner, D N, Orth, W E, Nicholson, T, Yasumoto, E L, Hewlett   +8 more
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The activation of rabbit intestinal adenylate cyclase by cholera toxin

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1989
Brush-border and basal-lateral membranes were prepared from rabbit intestinal epithelial cells by differential centrifugation and MgCl2 precipitation. The ADP-ribosylation of proteins in these fractions when incubated with [adenylate-32P]NAD+ and cholera toxin was investigated. Three proteins of molecular mass 45, 40 and 37 kDa were labelled in a toxin-
D, Longbottom, S, van Heyningen
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Toxins which activate adenylate cyclase.

Ciba Foundation symposium, 1985
Cholera toxin and other heat-labile enterotoxins have the same subunit structure (A5B) and all catalyse the mono ADP-ribosylation of Ns, a regulator of adenylate cyclase, probably at an arginine residue. They also ADP-ribosylate a variety of other membrane and soluble proteins at much slower rates. The rates differ from protein to protein but it may be
D M, Gill, M, Woolkalis
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Bordetella adenylate cyclase toxin: a swift saboteur of host defense

Current Opinion in Microbiology, 2006
Bordetella that infect mammals produce a multifunctional repeat in toxin (RTX) adenylate cyclase toxin known as CyaA, an excellent example of bacterial sophistication in subverting host defense. Recent reports show that interaction of CyaA with tracheal epithelial cells aids adhesion of Bordetella to ciliated mucosa and induces production of the pro ...
Jana, Vojtova, Jana, Kamanova, Peter, Sebo   +2 more
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Oligomeric behavior of Bordetella pertussis adenylate cyclase toxin in solution

Archives of Biochemistry and Biophysics, 2005
Adenylate cyclase (AC) toxin from Bordetella pertussis inserts into eukaryotic cells, producing intracellular cAMP, as well as hemolysis and cytotoxicity. Concentration dependence of hemolysis suggests oligomers as the functional unit and inactive deletion mutants permit partial restoration of intoxication and/or hemolysis, when added in pairs [M ...
Sang-Jin, Lee, M C, Gray, Kai, Zu, E L, Hewlett   +3 more
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Bordetella adenylate cyclase toxin: entry of bacterial adenylate cyclase into mammalian cells.

Advances in cyclic nucleotide and protein phosphorylation research, 1984
We have identified an adenylate cyclase toxin in urea extracts and culture supernatant fluids of Bordetella pertussis (2). The ability of this toxin and the lack of a strong correlation between its activity and adenylate cyclase activity found in urea extracts suggest that it is an oligomer of readily dissociable subunits.
D L, Confer, A S, Slungaard, E, Graf, S S, Panter, J W, Eaton   +4 more
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Altered Regulation of Adenylate Cyclase after Toxin-Catalyzed ADP-Ribosylation

1985
Publisher Summary This chapter presents an analysis of three types of ADP-Ribosylation, namely, ADP-ribosylation of Gs by choleragen, ADP-ribosylation of Gi by pertussis toxin, and ADP-ribosylation of transducin. The other known ADP-ribosyltransferases are bacteriophage products or bacterial toxins whose functions should probably be described as ...
M, Vaughan, J, Moss
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Adrenal cortex adenylate cyclase

Naunyn-Schmiedeberg's Archives of Pharmacology, 1977
Pretreatment of rat adrenal particulate fractions with cholera toxin in vitro markedly changed the properties of the membrane-bound adenylate cyclase. The basal activity of the enzyme was increased after cholera toxin treatment. The main action of the toxin was on the Vmax of the enzyme.
H, Glossmann, C J, Struck
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Internal Lysine Palmitoylation in Adenylate Cyclase Toxin from Bordetella pertussis

Science, 1994
A number of bacterial protein toxins, including adenylate cyclase (AC) toxin from Bordetella pertussis , require the product of an accessory gene in order to express their biological activities. In this study, mass spectrometry was used to demonstrate that activated, wild-type AC toxin was modified by amide-linked ...
M, Hackett, L, Guo, J, Shabanowitz, D F, Hunt, E L, Hewlett   +4 more
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Kluyveromyces lactis killer toxin inhibits adenylate cyclase of sensitive yeast cells

Nature, 1983
K1 killer toxin secreted by the K1 strain of Saccharomyces cerevisiae, has been well characterized. It is a simple protein of molecular weight (MW) 11,470 (ref. 3), encoded by a double-stranded, linear RNA plasmid, called M RNA, of MW 1.1-1.7 x 10(6) (refs 4-6). It is lethal to sensitive Saccharomyces cerevisiae which does not carry M RNA. Leakage of K+
Y, Sugisaki, N, Gunge, K, Sakaguchi, M, Yamasaki, G, Tamura   +4 more
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