Results 161 to 170 of about 175,144 (193)
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Bordetella adenylate cyclase toxin: a swift saboteur of host defense
Current Opinion in Microbiology, 2006Bordetella that infect mammals produce a multifunctional repeat in toxin (RTX) adenylate cyclase toxin known as CyaA, an excellent example of bacterial sophistication in subverting host defense. Recent reports show that interaction of CyaA with tracheal epithelial cells aids adhesion of Bordetella to ciliated mucosa and induces production of the pro ...
Jana, Vojtova +2 more
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Oligomeric behavior of Bordetella pertussis adenylate cyclase toxin in solution
Archives of Biochemistry and Biophysics, 2005Adenylate cyclase (AC) toxin from Bordetella pertussis inserts into eukaryotic cells, producing intracellular cAMP, as well as hemolysis and cytotoxicity. Concentration dependence of hemolysis suggests oligomers as the functional unit and inactive deletion mutants permit partial restoration of intoxication and/or hemolysis, when added in pairs [M ...
Sang-Jin, Lee +3 more
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Toxins which activate adenylate cyclase.
Ciba Foundation symposium, 1985Cholera toxin and other heat-labile enterotoxins have the same subunit structure (A5B) and all catalyse the mono ADP-ribosylation of Ns, a regulator of adenylate cyclase, probably at an arginine residue. They also ADP-ribosylate a variety of other membrane and soluble proteins at much slower rates. The rates differ from protein to protein but it may be
D M, Gill, M, Woolkalis
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Bordetella adenylate cyclase toxin: entry of bacterial adenylate cyclase into mammalian cells.
Advances in cyclic nucleotide and protein phosphorylation research, 1984We have identified an adenylate cyclase toxin in urea extracts and culture supernatant fluids of Bordetella pertussis (2). The ability of this toxin and the lack of a strong correlation between its activity and adenylate cyclase activity found in urea extracts suggest that it is an oligomer of readily dissociable subunits.
D L, Confer +4 more
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Adrenal cortex adenylate cyclase
Naunyn-Schmiedeberg's Archives of Pharmacology, 1977Pretreatment of rat adrenal particulate fractions with cholera toxin in vitro markedly changed the properties of the membrane-bound adenylate cyclase. The basal activity of the enzyme was increased after cholera toxin treatment. The main action of the toxin was on the Vmax of the enzyme.
H, Glossmann, C J, Struck
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Cholera Toxin: Membrane Gangliosides and Activation of Adenylate Cyclase
1977Asiatic cholera is a disease caused by the local action of a specific bacterial exotoxin on the small intestine and is characterized by a profuse outpouring of fluid at rates up to 20 liters per day (Pierce et al. 1971). The victims rapidly exhibit symptoms of hypovolemic shock, and if unassisted, may succomb within 8 hours of the onset of diarrhea ...
V. Bennett, P. Cuatrecasas
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Sequence of events in the activation of adenylate cyclase by cholera toxin.
Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften, 1977The toxin of Vibrio Cholera causes fluid secretion from the small intestine by stimulation of adenylate cyclase and elevation of intracellular cyclic AMP concentrations. The toxin is a protein composed of subunits responsible for binding to cell membranes and a subunit responsible for the activation of adenylate cyclase.
T, Kohler +5 more
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Bordetella extracytoplasmic adenylate cyclase: actions as a bacterial toxin.
Developments in biological standardization, 1986Virulent Bordetella organisms produce an adenylate cyclase which is extracytoplasmic in location, activated by the eukaryotic regulatory protein, calmodulin, and able to act as a toxin, promoting cyclic AMP accumulation in target mammalian cells. Initial steps in purification of this novel adenylate cyclase toxin reveal two forms: one which possesses ...
E L, Hewlett +9 more
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Bordetella pertussis toxin and adenylate cyclase
Trends in Pharmacological Sciences, 1983openaire +1 more source